The quality of life role in patients with locally advanced breast cancer in the comprehensive evaluation of the complex neoadjuvant treatment efficacy

O. V. Bondar, O. F. Dzygal

Abstract


In recent years, breast cancer has been the most common cancer and the most common cause of disability among women in developed countries.
Determining the role of the quality of life parameter of patients during complex neoadjuvant treatment with the use of polychemotherapy in systemic (SPCT), endolymphatic (ELPCT) and selective intraarterial (SIAPCT) variants in patients with locally advanced breast cancer M.
The study was conducted on the basis of materials from 526 cases of MR RMZ T4A-DN0-2M0. The total sample was divided into three subgroups by parameter of route of neoadjuvant polychemotherapy (PCT): first control group (22 patients) - SPCT; the second control group (27 patients) - ELPCT; study group (41 patients) - SIAPCT.
Clinical effect with qualitative changes of local status and transfer of patients to the category of those with resectable tumors appeared in 46% of women of the first control group after 6 courses of SPCT, in 59% of the second control group after 4 courses of ELPHT and in 90% of the studied group after 3 courses SIAPCT.
After 3 courses of PCT, statistically better results of the experimental group were obtained in the positive dynamics of quality of life index in the amplitude and chronometric complex logran study as a result of neoadjuvant SIAPCT compared with the first (p<0.001) and second (p<0.05) control groups.
On the social well-being scale, the control group showed the best dynamics (p> 0.05 in both comparisons) with a high evaluation of restitution of work and social status.
On the symptom scales in the third group, after each course of polychemotherapy, symptoms of nausea and loss of appetite were observed at a significantly lower intensity compared to both control groups within 15 - 25 points of the group (p<0.05 in both comparisons) and lasted 1 - 2 days less ( p<0.05 in both comparisons).
Quality of life (QOL) research is a reliable, informative, and cost-effective method for assessing a patient's state of health at both group and individual levels. In cancer studies, QOL assessment is an important criterion for evaluating treatment effectiveness and is of prognostic value.

Keywords


locally advanced breast cancer; systemic polychemotherapy; endolymphatic polychemotherapy; selective intra-arterial polychemotherapy; quality of life

Full Text:

PDF

References


Mahvi D.A., Liu R., Grinstaff M.W., Colson Y.L., Raut C.P. Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies. CA Cancer J. Clin. 2018; 68 (6): 488-505.

Narod S.A. Personalised medicine and population health: breast and ovarian cancer. Hum. Genet. 2018; 137 (10): 769-778.

PDQ Screening and Prevention Editorial Board. PDQ Cancer Information Summaries. National Cancer Institute (US); Bethesda (MD): Dec 18, 2019. Breast Cancer Screening (PDQ®): Health Professional Version.

Parada H., Sun X., Tse C.K., Olshan A.F., Troester M.A. Lifestyle Patterns and Survival Following Breast Cancer in the Carolina Breast Cancer Study. Epidemiology. 2019; 30 (1): 83-92.

White A.J., Bradshaw P.T., Hamra G.B. Air pollution and Breast Cancer: A review. Curr. Epidemiol. Rep. 2018; 5 (2): 92-100.

Gucalp A., Traina T.A., Eisner J.R., Parker J.S., Selitsky S.R., Park B.H., Elias A.D., Baskin-Bey E.S., Cardoso F. Male breast cancer: a disease distinct from female breast cancer. Breast Cancer Res. Treat. 2019; 173 (1): 37-48.

Rocque G.B., Williams C.P., Kenzik K.M., Jackson B.E., Azuero A., Halilova K.I., Ingram S.A., Pisu M., Forero A., Bhatia S. Concordance with NCCN treatment guidelines: Relations with health care utilization, cost, and mortality in breast cancer patients with secondary metastasis. Cancer. 2018; 124 (21): 4231-4240.

Gautam S., Sylwestrzak G., Barron J., Chen X., Eleff M., Debono D., Nguyen A., Fisch M. Results From a Health Insurer's Clinical Pathway Program in Breast Cancer. J. Oncol. Pract. 2018; 15: JOP1800157.

Bottomley A., Therasse P., Piccart M., Efficace F., Coens C., Gotay C., Welnicka-Jaskiewicz M., Mauriac L., Dyczka J., Cufer T., Lichinitser M.R., Schornagel J.H., Bonnefoi H., Shepherd L.; European Organisation for Research and Treatment of Cancer Breast Cancer Group; National Cancer Institute of Canada; Swiss Group for Clinical Cancer Research. Health-related quality of life in survivors of locally advanced breast cancer: an international randomised controlled phase III trial. Lancet Oncol. 2005; 6 (5): 287-294.

Ghislain I., Zikos E., Coens C., Quinten C., Balta V., Tryfonidis K., Piccart M., Zardavas D., Nagele E., Bjelic-Radisic V., Cardoso F., Sprangers MAG, Velikova G., Bottomley A.; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group; Breast Cancer Group; EORTC Headquarters. Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials. Lancet Oncol. 2016; 17 (7): 294-304.




DOI: http://dx.doi.org/10.5281/zenodo.3966271

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author (s) 2019

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)