Treatment of cerebral palsy using stem cells

Magdalena Hołowczuk, Dominika Janeczko, Anna Orzeł, Barbara Klatka, Michał Terpiłowski

Abstract


Cerebral palsy is a wide group of diseases whose common feature are motor disorders. Patients affected by this condition show abnormalities of movement and posture.
Various possible causes of damage were identified. Hypoxia, ischemia, infection, injury and congenital defects are one of the conditions that increase the risk of the disease. The first signs of cerebral palsy noted by parents are: incorrect head and torso stabilization, inability to sit and walk at the right age. There are currently no treatments available that would indicate good efficacy. . In recent years, stem cell therapies have enjoyed considerable interest. The encouraging results of many preclinical studies have indicated that stem cell therapy may have benefits in neonatal diseases.
Despite many encouraging reports, data on the effectiveness of stem cell therapy in cerebral palsy are still insufficient. Scientists should continue to research the success of the therapy.

Keywords


stem cells; cerebral palsy

Full Text:

PDF

References


https://www.mp.pl/pacjent/pediatria/choroby/choroby-neurologiczne/141866,mozgowe-porazenie-dzieciece

The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review. Kiasatdolatabadi A, Lotfibakhshaiesh N, Yazdankhah M, Ebrahimi-Barough S, Jafarabadi M, Ai A, Sadroddiny E, Ai J; Mol Neurobiol. 2017 Sep;54(7):4963-4972. doi: 10.1007/s12035-016-0030-0. Epub 2016 Aug 13.

Stem Cells... friend or enemy? Paweł Kowalczyk, Katarzyna Hulka, Dorota Dziuban, Maciej Filocha; Borgis - Nowa Medycyna 3/2012, s. 52-55

Generation of germline-competent induced pluripotent stem cells. Okita K, Ichisaka T, Yamanaka S; Nature 2007; 448 (7151): 313-317. 5. Goodell, M. J Exp Med 1996; 183: 1797-1806.

Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Christopher R. Nitkin, Johnson Rajasingh, Courtney Pisano, Gail E. Besner, Bernard Thébaud and Venkatesh Sampath; Pediatric Research (2019), ; https://doi.org/10.1038/s41390-019-0425-5

Mesenchymal stem cells prevent hydrocephalus after severe intraventricular hemorrhage. Ahn, S. Y. et al.; Stroke 44, 497–504 (2013).

Improvement of human umbilical cord mesenchymal stem cell transplantation on glial cell and behavioral function in a neonatal model of periventricular white matter damage. Zhu, L. H. et al.; Brain Res 1563, 13–21 (2014).

A Randomized, placebo-controlled trial of human umbilical cord blood mesenchymal stem cell infusion for children with cerebral palsy. Huang, L. et al.; Cell Transpl. 27, 325–334 (2018).

The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review, Anahita Kiasatdolatabadi, Nasrin Lotfibakhshaiesh, Meysam Yazdankhah, Somayeh Ebrahimi-Barough, Mina Jafarabadi, Arman Ai, Esmaeil Sadroddiny, Jafar Ai; Mol Neurobiol DOI 10.1007/s12035-016-0030-0; Springer Science+Business Media New York 2016

Non-haematological uses of cord blood stem cells. Br J Haematol Harris DT (2009) 147(2):177–184. doi:10.1111/j.1365-2141.2009.07767.x

Current proceedings of cerebral palsy. Fan HC, Ho LI, Chi CS, Cheng SN, Juan CJ, Chiang KL, Lin SZ, Harn HJ (2015) Cell transpl 24(3):471–485. doi:10.3727/096368915x68693119




DOI: http://dx.doi.org/10.5281/zenodo.3478556

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 2011: 5.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)