Interrelation of morphometric and biochemical changes in oral mucous membrane in animals with gastroduodenitis depending on the inflammatory response

Ihor Mysula, Valentyna Bondarchuk, Gustaw Wójcik, Walery Zukow, Nataliya Sydliaruk, Yuriy Mysula, Marianna Mysula


Introduction. There is noconsensus opinion regarding the connection of morphometric and biochemical changes in oral mucous membrane of animals with gastroduodenitis depending on the type of inflammatory response. For this reason, it remains important to study the relationship between changes in the morphometric parameters of the oral mucosa, lipid peroxidation indices and the antioxidant system under the influence of various types of inflammatory reaction in the conditions of experimental gastroduodenitis.
Material and methods. Experiments were carried out on 42 white male rats weighing 180-200 g housed under normal conditions on a standard vivarium diet; acute gastroduodenitis was simulated for 7 days by inserting by the probe into the stomach 0.25 ml of 10% solution C2H5OH and after 5 minutes 0.5 ml of 1.25% solution of HCl. Three different types of inflammatory response were also modeled.
Results. The most significant changes in oral mucosa on the basis of morphometric and biochemical parameters were found in animals with hyperergic type of inflammatory reaction. Rats with hypoergic type of inflammatory reaction had a lower depth of morphometric and biochemical changes. Morphometric changes were most significant on the tenth day of the experiment, regardless of the type of inflammatory reaction.
Conclusions. The obtained results confirm that changes in morphometric and biochemical parameters depend on the type of inflammatory reaction.


cheek; mucous membrane; morphometric parameters; biochemical changes; type of inflammatory response; gastroduodenitis.

Full Text:



Ten Cate A.R., editor. Oral histology. Development, structure and function. St. Louis, MO, Mosby: The C.V. Mosby Company; 1989.

Naumova E.A., Dierkes T., Sprang J., Arnold W.H. The oral mucosal surface and blood vessels. Head And Face Med. 2013; 9: 8-15.

Ananevich I.M., Popadinets O.G., Sobol L.V., Dubina N.V. Morfofunktsionalnyi stan slyzovoi obolonky rotovoi porozhnyny v umovakh vplyvu ekzo- ta endohennykh faktoriv. [The morphofunctional state of mucous membrane of oral cavity in conditions of ekso- and endogenous factors influence]. Visnyk problem biolohii i medytsyny. 2016; 2 (1): 306-310 (in Ukrainian).

Tsvyntarna I.Ya., Mysula I.R. Stan perekysnoho okyslennia lipidiv ta antyoksydantnoi systemy pry riznykh typakh zapalnoi reaktsii v parodonti. [The state of lipid peroxidation system and antioxidant system during different types of reactions in the periodontium]. Aktualni problemy transportnoi medytsyny. 2014. 36 (2): 43-47 (in Ukrainian).

Reznikov O.G. Zahalni etychni pryntsypy eksperymentiv na tvarynakh. [General ethical principles of experiments on animals]. The first national congress on bioethics. Endocrynologija. 2003; 1 (8): 142-145 (in Ukrainian).

Patent 98021 Ukraine, IPC (51) G09B 23/78 G01N 23/48 G01N 33/84 G01N 33/98 (2006.01). Method of inflammatory processes modeling in mucous membrane of the oral cavity / Mysula N.I., Avdeev O.V., I. Ya. Horbachevsky Ternopil State Medical University. - № u201010071; appl. 2014 12673; publ. 10.04.2015, bulletin No. 7, 2015.

Patent 57189 Ukraine, IPC (2011.01) A61K 31/00 G09B 23/28 (2006.01). Method of periodontitis modeling / Avdeev O.V., I. Ya. Horbachevsky Ternopil State Medical University - № u201010071; appl.16.08.2010; publ.10.02.2011, bulletin No. 3, 2011.

Patent 66298 Ukraine, IPC A61K 39/104 (2006.01); G09B 23/28 (2006.01). Method for periodontitis modeling / Avdeev O.V., I. Ya. Horbachevsky Ternopil State Medical University - № u201108090; appl.29.06.2011; publ.26.12.2011, bulletin No. 24, 2011.

Avtandilov G.G. Osnovyi kolichestvennoy patologicheskoy anatomii. [Fundamentals of quantitative pathological anatomy]. Medicyna. 2002 (in Russian).

Vladimirov Yu.A., Archakov A.Yu. Perekisnoe okislenie lipidov v biologicheskih membranah.

[Peroxide oxidation of lipids in biological membranes]. Medicyna. 1972; 252 (in Russian).

Kolesova O.E., Markin A.A., Fedorova T.N. Perekisnoe okislenie lipidov i metodyi opredeleniya produktov peroksidatsii v biologicheskih zhudkostiah. [Lipid Peroxidation and method of determining the lipoproxidation products in biological fluids]. Laboratornoje delo. 1984; 9: 540-546 (in Russian).

Chevary S., Chaba Y., Sekei Y. Rol superoksiddismutazyi v okislitelnyih protsessah kletki i metod opredeleniya ee v biologicheskih materialah. [The role of Superoxide Reductase in the oxidative processes of cells and methods of it`s determining in biological materials]. Laboratornoje delo. 1985; 11: 678-681 (in Russian).

Korolyuk M.A., Ivanova L.Yu., Majorova Y.G., Tokarev V.E. Metod opredeleniya aktivnosti katalazy. [Method for determining the activity of catalase]. Laboratornoje delo. 1988; 1: 16-18 (in Russian).

Tverdohlib N.O. Morfometrychna kharakterystyka slyzovoi obolonky porozhnyny rota pry mekhanichnii zhovtianyts. [Morphometric characteristics of the oral cavity mucous membrane in patients with mechanical jaundice]. Shpytalna khirurhija 2013; 4: 45-49 (in Ukrainian).

Somma F., Castagnola R., Bollino D. Oral inflammatory process and general health. Part 1. Focal infection and oral inflammation of the lesion. European Review of Medical and Pharmacological Sciences. 2010; 14 (12): 1085-1095.

Romanenko E.G. Strukturnyie izmeneniya v slizistyih obolochkah verhnih otdelov pischevaritelnogo trakta pri eksperimentalnom gastroduodenite. [Structural changes in mucous membrane of upper parts of the gastro-intestinal tract during experimental gastroduodenitis]. Morfologiya. 2013; VII (1): 73-77 (in Russian).



  • There are currently no refbacks.

Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski