Interrelation of morphometric and biochemical changes in oral mucous membrane in animals with gastroduodenitis depending on the inflammatory response
Abstract
Material and methods. Experiments were carried out on 42 white male rats weighing 180-200 g housed under normal conditions on a standard vivarium diet; acute gastroduodenitis was simulated for 7 days by inserting by the probe into the stomach 0.25 ml of 10% solution C2H5OH and after 5 minutes 0.5 ml of 1.25% solution of HCl. Three different types of inflammatory response were also modeled.
Results. The most significant changes in oral mucosa on the basis of morphometric and biochemical parameters were found in animals with hyperergic type of inflammatory reaction. Rats with hypoergic type of inflammatory reaction had a lower depth of morphometric and biochemical changes. Morphometric changes were most significant on the tenth day of the experiment, regardless of the type of inflammatory reaction.
Conclusions. The obtained results confirm that changes in morphometric and biochemical parameters depend on the type of inflammatory reaction.
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DOI: http://dx.doi.org/10.5281/zenodo.3471770
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