Influence of mineral water on the structural and functional state of the rats kidneys with metabolic syndrome

S. Gushcha, B. Nasibullin, W. Zukow, I. Savitskyi, V. Volyanska


In white rats in the setting of development of metabolic syndrome inhibition of the urinary and excretory functions of the kidney, with impaired water-ion balance (the kidneys excrete slightly hyperosmotic urine in a small amount) on the background of structural signs of dystrophies. Daily diuresis is reduced by 37% due to a decrease in glomerular filtration rate (GFR) by 22% and an increase in the percentage of tubular reabsorption (p <0.001), excretion of creatinine, urea and chloride decreased by 22%, 15% and 56%. The excretion of potassium and sodium ions increases by 14% and 38%, respectively. The daily urine is greatly delayed. Two-week internal course administration of low-mineralized sodium chloride water has a positive effect on impaired renal function: the volume of diuresis is increased by 15% by accelerating GFR by 20% and restoring the value of tubular reabsorption. Creatinine excretion is increased by 20% and urea by 32%. The excretion of potassium and sodium ions is increased by 50% and 166%, respectively.
Excretion of chloride ions and urine pH is fully restored. Microscopically determined residual manifestations of dystrophic processes in the kidneys, which against the background of the recovery of processes of urination and stimulation of ion-regulating and excretory functions of the kidneys, indicates the ability of the applied sodium chloride MW to correct the structural and functional disorders of the metabolic syndrome.


mineral water; metabolic syndrome; structural and functional state of the kidneys; white rats.

Full Text:



Krewicka RE, Siedlecka D, Makuch M, Romaniuk A. Patophysiology of metabolic syndrome in mentally ill patients treatedbyantipsychotics. Journal of Education, Heal thand Sport. 2019; 9 (8): 29–34. DOI:

Shcherbakov MYu. Modern views on diagnostics, classification, principles of formation of risk group and approach to treatment of children with metabolic syndrome. Pediatrics. 2010; 89 (3): 123–127.

Voloshin OB, Naydyonova OV, Dukova OR. Efficiency of Polyana Kvasova mineral water use in complex rehabilitation treatment of patients with hypertension with metabolic syndrome. Medical rehabilitation, balneology, physiotherapy. 2014; 3: 37–39.

Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018; 20 (2):12. doi: 10.1007/s11906-018-0812-z.

Simmons RK, Alberti KG, Gale EA. Et al. The metabolic syndrome: useful concept or clinical tool? Report of a WHO expert consultation. Diabetologia. 2010; 53(4): 600–605.

Grundy S. Metabolic syndrome update. Trends.Cardiovasc, Med. 2016; 26 (4): 364–373.

Frolova EB, Tsibulkin N.A., Abrakhmanova AI. Metabolic syndrome as an etiological factor in emergency conditions. Bulletin of modern clinical medicine. 2018; 11 (5): 118–124.

Wada Т, Kenmochi Н, Miychita Y. et al. Spironolactone improves glucose and lipid metabolism by a meliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fatandhigh-fructosediet. Endocrinology. 2010; 151 (5): 2040–2049.

Babov KD, Gushcha SG, Nikipelova OM, Drahomiretska NV, Zabolotnaya IB, Nasibullin BA, Tikhokhid LV, Pirogov AYa. Poltava Bishofit - biological action. The effectiveness of therapeutic applications. Odessa: POLYGRAPH, 2018: 102 p.

Nica AS, Heorghievici GL, Mitoiu BI, Clantau D, Radulian G. The Use of Mineral Therapeutic Waters in Metabolic Disorders - a Review of the Literature Modern Medicine. 2018; 25 (1).

Zabolotna IB, Gushcha SG, Mikhailenko VL. Non-alcoholic fatty liver disease and mineral waters of Ukraine – opportunities of application (experimental-clinical studies). Balneo Research Journal. 2018; 9 (3): 270–276. DOI 10. 1268/balneo.2018.194.

Kolesnik KE. The use of Ukrainian Iodovana mineral water in the rehabilitation treatment of children with an insulin-dependent form of diabetes mellitus in the conditions of the «Pobeda» sanatorium. Ukrainian balneological journal. 2002; 2: 54–57.

Rotaenko AP, Shvardak MV, Gorytska SI, Gaynas LA/ Metabolic shifts in patients with diabetes who were treated in the health resort "Bruise". Uzhgorod University Scientific Bulletin, series "Medicines". 2010; 38: 89–91.

Antoniuk MV, Ivanova IL. Antiatherogenic properties of various types of carbonic mineral waters with their internal use. Questions of balneology, physiotherapy and physiotherapy. 2002;1: 20–23.

Barieva YuB, Botvineva LA, Kaysinova AS, Samsonova NA. Role of physical loads and drinking mineral water in prevention and treatment of obesity - basis of metabolic syndrome. Journal Physical Therapy, Balneotherapy, Rehabilitation. 2017;16 (5): 228–233. DOI:

Gushcha SG, Nasibullin BA, Plakida AL, Voluanska VS, Balashova IV. Metabolic syndrome: The corrective effect of mineral water with an increased content of organic substances. American Journal of Chemistry and Materials Science. 2018; 5 (5): 85–90.].

Medical-hydrogeochemical factors of geological environment in Ukraine ( Ed By HI Rudko. Kyiv — Chernovtsy: Bukrek, 2015: 724 р.

Instruction 2010/63/EU of European Parliament and Council on animals used for research and other purposes protection. Official Journal. 2010;276:33–79.

Order of MOH of Ukraine No. 692 dated 28.09.2009 «On approval of the recommendations of the research methods of biological effects of natural medicinal resources and preformed remedies».

Nasibullin BA, Gushcha SG, Babov KD, Trubka IO. еt al A guide to the reproduction of experimental models of common nosological forms and their verification]. Odessa. 2018: 82 р.



  • There are currently no refbacks.

Copyright (c) 2019 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski