Prevalence of polymorphism (-174 G / C) of IL-6 gene in patients with acute brucellosis and hepatobiliary system damage

Elchin Huseynov Mammad oglu

Abstract


Modern brucellosis is characterized by high variability of clinical symptoms. Its evolution is going in the direction of acute forms increasing, with an early development of focal metastatic and infectious-allergic lesions, which, in their turn, increase the severity of the disease’s course. This testifies to early sensitization development in patients in endemic regions already in the acute phase of brucellosis. The objective: to determine the prevalence of the polymorphism (-174 G / C) of the IL-6 gene in patients with hepatic damages in acute brucellosis in the Republic of Azerbaijan. 178 patients were examined, 120 of them fully met all the criteria for inclusion in the study, so they formed the treatment group. The definition of polymorphism (-174 G / C) of the IL-6 gene was made to all patients. Statistical analysis of the results obtained was performed with "SPSS 20.0" and "STATISTICA 6.0" programs. Among 120 patients with acute brucellosis, the disease of the hepatobiliary system had 43 (35.8%) persons according to the generalization of laboratory and instrumental methods of examination. Genotype C / C IL-6 gene was 4.2 times more frequent in patients with acute brucellosis and liver damage than in hepatic lesions-free persons. It was found that among the carriers of C / C genotype, risk of brucellosis prevalence with hepatic damage is significantly higher (χ2 = 12.26; p = 0.002; OR = 0.97; 95% CI [0.28 - 3.41]), while the carriership of the homozygous genotype G / G, on the contrary, has protective effect on the development of brucellosis (OR = 0.16, 95% CI [0.05 - 0.50]).

Keywords


acute brucellosis; hepatitis; polymorphism; IL-6.

Full Text:

PDF

References


Malov V. A. Therapeutic masks of brucellosis / VA Malov // Pharmtech. - 2011. - No. 4. - P. 22-28.

Actual problems of epidemiology on prosperous territories for brucellosis / E. P. Lyapina, N. A. Petrenko, A. Shuldyakov, L. A. Varshamov // Sanitary protection of territory. - 2012. - Vol. 2, No. 1-2. - P. 167.

Duysenova AK. Zoonotic Infections: Yesterday, Today and Tomorrow / A.K. Duysenova // Central Asian Scientific and Practical Journal on Public Health. - 2011. - No. 4. - P. 2-4.

Al-Nakshabandi N. A. The Spectrum of Imaging Findings of Brucellosis: A Pictorial Essay //Canadian Association of Radiologists Journal. – 2012. – Vol. 63. – №. 1. – P. 5-11.

Akritidis N. et al. The liver in brucellosis //Clinical gastroenterology and hepatology. – 2007. – Vol. 5. – №. 9. – P. 1109-1112.

Lulu A. R. et al. Human brucellosis in Kuwait: a prospective study of 400 cases //QJM: An International Journal of Medicine. – 1988. – Vol. 66. – №. 1. – P. 39 - 54.

Mermut G. et al. Clinical, diagnostic and therapeutic approaches to complications of brucellosis: an experience of 12 years //Medical Principles and Practice. – 2012. – Vol. 21. – №. 1. – P. 46-50.

Heller T. et al. Patterns of hepatosplenic Brucella abscesses on cross-sectional imaging: a review of clinical and imaging features //The American journal of tropical medicine and hygiene. – 2015. – Vol. 93. – №. 4. – P. 761-766.

Casallas J. C. G. et al. Acute liver failure complication of brucellosis infection: a case report and review of the literature //Journal of medical case reports. – 2018. – Vol. 12. – №. 1. – P. 62.

Dean A. S. et al. Clinical manifestations of human brucellosis: a systematic review and meta-analysis //PLoS neglected tropical diseases. – 2012. – Vol. 6. – №. 12. – P. e1929.

Rodríguez-Zapata M. et al. Human brucellosis is characterized by an intense Th1 profile associated with a defective monocyte function //Infection and immunity. – 2010. – Vol. 78. – №. 7. – P. 3272 - 3279.

Diehl S., Rincón M. The two faces of IL-6 on Th1/Th2 differentiation //Molecular immunology. – 2002. – Vol. 39. – №. 9. – P. 531-536.

Aypak C., Altunsoy A., Çelik A. K. Epidemiological and clinical aspects of human brucellosis in eastern anatolia //Journal of Nippon Medical School. – 2012. – Vol. 79. – №. 5. – P. 343 - 348.

Akbulut H. et al. Cytokine levels in patients with brucellosis and their relations with the treatment //Indian journal of medical microbiology. – 2007. – Vol. 25. – №. 4. – P. 387.

Rudofsky Jr G. et al. The− 174G> C IL-6 gene promoter polymorphism and diabetic microvascular complications //Hormone and metabolic research. – 2009. – Vol. 41. – №. 04. – P. 308-313.

Manginas A. et al. Inflammatory cytokine gene variants in coronary artery disease patients in Greece //Coronary artery disease. – 2008. – Vol. 19. – №. 8. – P. 575-582.

Asaei S., Rasouli M., Moravej A. Interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis //Iranian Journal of Immunology. – 2013. – Vol. 10. – №. 3. – P. 158-166.

Budak F. et al. IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis //Cytokine. – 2007. – Vol. 38. – №. 1. – P. 32-36.

Nassaji M., Govhary A., Ghorbani R. Epidemiological, clinical and laboratory findings on adult patients with acute brucellosis: A case-control study //Acta Medica Mediterranea. – 2015. – P. 1319-1325.

Memish Z. et al. Brucella bacteraemia: clinical and laboratory observations in 160 patients //Journal of infection. – 2000. – Vol. 40. – №. 1. – P. 59-63.

Gür A. Et al. Complications on brucellosis on different age groups: a study of 283 cases on south eastern Anatolia on Turkey //Yonsei medical journal. – 2003. – Vol. 44. – №. 1. – P. 33-44.

Gunal O. Et al. The IL4-VNTR P1 allele, IL4-VNTR P2P2 genotype and IL4-VNTR_IL6-174CG P2P1-GG genotype are susceptable with an increased risk in Brucelosis //Japanese journal of infectious diseases. – 2016. – P. JJID. 2015.550.

Karaoglan I. et al. TNF-alpha, TGF-beta, IL-10, IL-6 and IFN-gamma gene polymorphisms as risk factors for brucellosis //New Microbiol. – 2009. – Vol. 32. – №. 2. – P. 173-178.




DOI: http://dx.doi.org/10.5281/zenodo.3522333

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author (s) 2019

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)