Sexuality and fertility of young women suffering from breast cancer
Abstract
The aim of this study is to review on the occurrence of sexual dysfunction and fertility disorders among young patients suffering from BC. The impact of BC treatment on the occurrence of these disorders has been analyzed. This review emphasizes also possible methods of sexual dysfunction and potential options of fertility protection which may be used in women who want to get pregnant after the end of the treatment.
This review is based on available data from medical publications and guidelines from 1987 to 2019, addressing issues of sexuality and fertility in young patients with breast cancer.
Young patients suffering from BC experience a variety of sexuality and fertility disorders. Sexual dysfunction includes among others: reduced libido, dyspareunia and difficulty in reaching an orgasm. The reason of the deterioration of the quality of sexual life is complex. Among the emotional factors, the most important role is played by changes in appearance, such as hair loss or breast amputation. Organic causes include dryness or loss of vaginal elasticity. The risk of fertility disorders is primarily associated with the use of cytotoxic drugs, causing premature ovarian failure and inducing amenorrhea. Chemotherapeutic agents with the highest risk of gonadotoxicity are alkylating drugs. Oncofertility is a branch of medicine combining oncology and reproductive medicine. Fertility protection of women who desire bearing a child after treatment is possible thanks to various methods of preservation. These include cryopreservation of embryos and oocytes, ovarian suppression with the use of GnRH analogs, ovarian transposition, freezing and transplantation of ovarian tissue. The most recommended method is embryo cryopreservation at present. Available data suggest no increased risk of cancer recurrence due to pregnancy in women after BC treatment.
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International Agency for Research on Cancer, World Health Organisation, Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018, 2018
http://onkologia.org.pl/raporty/
Radecka B., Litwiniuk M., Breast cancer in young women, “Ginekologia Polska” 2016, 87, 9: 659-663
Azim H.A., Partridge A.H., Biology of breast cancer in young women, “Breast Cancer Research” 2014, 16:427-435
Anders C.K., Fan Ch., Parker J.S., Breast carcinomas arising at a youngage: unique biology or a surrogate for aggressive intrinsic subtypes?, “J Clin Oncol.” 2011, 29:18–20
Gnerlich J.L., Deshpande A.D., Jeffe D.B., Sweet A., White N., Margenthaler J.A., Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease, “J Am Coll Surg” 2009, 208:341–347
Keegan T.H., DeRouen M.C., Press D.J., Kurian A.W., Clarke C.A., Occurrence of breast cancer subtypes in adolescent and young adult women, “Breast Cancer Res” 2012, 14:R55
Azim H.A., Michiels S., Bedard P.L., Singhal S.K., Criscitiello C., Ignatiadis M., Haibe-Kains B., Piccart M.J., Sotiriou C., Loi S., Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling, “Clin Cancer Res” 2012, 18:1341–1351
Hungr C., Sanchez-Varela V., Bober S.L., Self-image and sexuality issues among young women with breast cancer: practical recommendations, “Revista de Investigacion Clinica” 2017, 69:114-122
Kasum M., Beketić-Oreškovićb L., Peddic P.F., Slavko O., Johnson R.H., Fertility after breast cancer treatment, “European Journal of Obstetrics & Gynecology and Reproductive Biology" 2014, 173:13-18
Voogd A.C., Nielsen M., Peterse J.L., Difference on risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials, “J Clin Oncol” 2001, 19:1688–97
Arriagada R., Le M.G., Contesso G., Guinebretiere J.M., Rochard F., Spielmann M., Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer, “Ann Oncol” 2002, 13:1404–1413
Préau M., Bouhnik A.D., Le Coroller Soriano A.G., Two years after cancer diagnosis, what is the relationship between health-related quality of life, coping strategies and spirituality?, “Psychol Health Med.” 2013, 18:375–386
Baucom D.H., Porter L.S., Kirby J.S., Gremore T.M., Keefe F.J., Psychosocial issues confronting young women with breast cancer, “Breast Dis” 2005, 23:103–113
Habold D., Bondil P., L’intervention sexologique en oncologie, “Presse Med” 2014, 43:1120-1124
Alder J., Zanetti R., Wight E., Urech C., Fink N., Bitzer J., Sexual dysfunction after premenopausal stage I and II breast cancer: do androgens play a role?, “J Sex Med” 2008, 5(8):1898–906
Kedde H., Van de Wiel H.B.M., Weijmar Schultz W.C.M., Wijsen C., Sexual dysfunction in young women with breast cancer, “Support Care Cancer” 2012, 21:271–280
Jankowska M., Sexual functioning in young women in the context of breast cancer treatment, “Reports of practical oncology and radiotherapy” 2013, 18:193–200
Blouet A., Zinger M., Capitain O., Landry S., Bourgeois H., Seegers V.T., Pointreau Y., Sexual quality of life evaluation after treatment among women with breast cancer under 35 years old, “Support Care Cancer” 2019, 27:879–885
Ghizzani A., Bruni S., Luisi S., The sex life of women surviving breast cancer, “Gynecological Endocrinology” 2018, 34(10):821-825
Lopresti M., Rizack T., Dizon D.S., Sexuality, fertility and pregnancy following breast cancer treatment, “Gland Surg” 2018, 7(4):404-410
Kedde H., Van de Wiel H.B.M., Weijmar Schultz W.C.M., Wijsen C., Subjective sexual well-being and sexual behavior in young women with breast cancer, “Support Care Cancer” 2013, 21:1993–2005
Kinsinger S.W., Laurenceau J.P., Carver C.S., Antoni M.H., Perceived partner support and psychosexual adjustment to breast cancer, “Psychol Health” 2011, 26:1571-1588
Lee S.J., Schover L.R., Partridge A.H., Patrizio P., Wallace W.H., Hagerty K., Beck L.N., Brennan L.V., Oktay K., American Society of Clinical Oncology recommendations on fertility preservation in cancer patients, “J Clin Oncol” 2006, 24:2917–2931
Dabrosin C., An overview of pregnancy and fertility issues in breast cancer patients, “Annals of medicine” 2015, 47(8):673-678
Partridge A.H., Ruddy K.J., Fertility and adjuvant treatment in young women with breast cancer, “Breast” 2007, 16:175-181
De Pedro M., Otero B., Martin B., Fertility preservation and breast cancer: a review, “Ecancer Medical Science” 2015, 9:503
Ronn R., Holzer H., Breast cancer and fertility: an update, “Wolters Kluwer Health” 2015, 9(3):285-293
Gracia C.R., Chang J., Kondapalli L., Ovarian tissue cryopreservation for fertility preservation in cancer patients: successful establishment and feasibility of a multidisciplinary collaboration, “Journal of Assisted Reproduction and Genetics” 2012
Hickey M., Peate M., Saunders C.M., Friedlander M., Breast cancer in young women and its impact on reproductive function, “Human Reproduction Update” 2009, 15(3):323–339
http://oncofertility.pl/
http://oncofertility.pl/osrodki/
Zalecenia Grupy Roboczej ds. Zachowania Płodności u Chorych Onkologicznych i Chorych Hematologicznych oraz Innych Chorych Leczonych Terapiami Gonadotoksycznymi “ONCOFERTILITY” (GROF) Polskiego Towarzystwa Ginekologii Onkologicznej, 2017
Christinat A., Pagani O., Fertility after breast cancer, “Maturitas” 2012, 73:191– 196
Oktay K., Buyuk E., Libertella N., Akar M., Rosenwaks Z., Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation, “J Clin Oncol” 2005, 23:4347–53
Oktay K., Buyuk E., Veeck L., Embryo development after heterotopic transplantation of cryopreserved ovarian tissue, “Lancet” 2004, 363:837–840
Donnez J., Dolmans M.M., Pellicer A., Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation, “Fertil Steril” 2013, 99:1503–1513
https://www.nccn.org/professionals/physician_gls/f_guidelines.asp
Schover L.R., Kaaij M., Dorst E., Creutzberg C., Huyghe E., Kiserud C.E., Sexual dysfunction and infertility as late effects of cancer treatment, “EJC Supplements” 2014, 12:41-53
Azim H.A., Santoro L., Pavlidis N., Safety of pregnancy following breast cancer diagnosis: a meta-analysis of 14 studies, “Eur J Cancer” 2011, 47:74-83
Mulvihill J.J., McKeen E.A., Rosner F., Zarrabi M.H., Pregnancy outcome in cancer patients, “Cancer” 1987, 60:1143–50
Blakely L.J., Buzdar A.U., Lozada J.A., Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence, “Cancer” 2004, 100:465–469
DOI: http://dx.doi.org/10.5281/zenodo.3358747
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