Influence of the chronic stress of pregnant rats on their offspring’s morpho-functional liver condition

O. Nikolayeva, M. Kuznetsova, O. Lytvynenko


The morphofunctional state of the rats offspring liver, born from femal rats underwent chronic immobilization stress during pregnancy was studied. It has been revealed that chronic stress in female rats during pregnancy wields considerable influence over liver morphology and lipid-synthesizing function of their offspring. Pronounced discomplexing of the beam-radiary structure, increase of stromal - parenchymal index due to increase in stromal and decrease in the parenchymal components of the liver and decrease level of expression of endothelial synthase has been morphologically revealed. Biochemical study of the liver homogenate revealed signs of impaired synthesis, secretion and reuptake of lipids (increase of cholesterol, tryglyceerids and non-esterified fatty acids and decrease of phospholipids. In the offsprings blood serum dyslipidemia (increase of cholesterol and low-density lipoproteins level) was detected. All this is a risk factor for fibrosis, fatty hepatosis and level cirrhosis development.


chronic stress, hepatic morphofunctional state, pregnant rat, offspring

Full Text:



Duduk NO, Zimatkin SM. Cholestasis in pregnancy and its consequences for mother and offspring. Journal of the MGU, 2011, №1: P.3.

Belousov SE. Epidemiology and risk factors for the development of diseases of the digestive system in children. Health of Ukraine, 2012; Thematic issue.- P. 48-51.

D’gata ID, Balistreri WF. Evaluation of liver diseases in the pediatric patient. Pediatric in Review, 1999; № 11Vol. 20: P. 376-389.

Ibaldin AS, Sharunov GI, Buiraev KM. Liver diseases in pregnant women, treatment principles. Vestnik Kaz NMU, 2013; No. 4 (2): P. 269.

Chistova LV, Borovik TE, Semenova NN, Surkov AN, Ryzhkov LA, Zakharov EU. Non-alcoholic fatty liver disease in children. Pediatric Pharmacology, 2010; №6. Volume 7: P. 68 - 72.

Fomenko SE, Kushnerov NF, Sprygin VG, Momot TV. Disruption of metabolic processes in the liver of rats under the action of stress. Pacific Medical Journal, 2013; No. 2: P. 67 - 70.

Saroyan MA, Khudaverdian AD. Effect of psycho-emotional stress on the content of thyroxin and somatotropic hormone in the blood of pregnant rats and their offspring. Biologist. Journal Armenia, 2014; 4 (66): P. 11 - 16.

Korenevskaya ON, Gorodetskaya IW, Evdokimova OV, Gusakova EA. Dynamics of the response of the pituitary-thyroid system under chronic stress in rats with intact and altered thyroid status. Bulletin of VSMU, 2011; №4. V. 10: P. 21 - 29.

Grekov EA, Kirpatovsky VI, Golovanov SA, Drozheva VV, Kazachenko AV. Assessment of the effect of metabolic syndrome, androgen deficiency and stress on the development of chronic kidney and liver disease in male white rats. Experimental and Clinical Urology, 2012; No. 4: P. 8 - 13.

Ricart-Jane D, Rodriguez-Sureda V, Benavides A, Peinado-Onsurbe J, Lopez-Tejero MD, Llobera M. Immobilization stress and intermediate lipoproteins in the rat. Metabolism, 2002; 51: P. 925-31.

Lesage J, Del-Favero F, Leonhardt M, Louvart H, Maccari S, Vieau D, Darnaudery M. Prenatal stress. Journal of Endocrinology, 2004; 181: P. 291-296.

Franko KL, Forhead AJ, Fowden AL. Postnatal growth and glucocorticoid metabolism in rats. J. Endocrinol, 2010; 204 (3): P. 319-29.

Kuznetsov SV, Kuznetsov VF, Khorinko VP, Kulemin LM. Age-related features of the ratio of regeneration and damage to rat hepatocytes under stress and the pathogenetic aspects of their correction. Perm Medical Journal, 2012; No. 3. Volume XXIX: P. 84 - 92.

Pat. 81453 Ukrainian MPK G09B 23/28 (2006.01) G09B 23/24 (2006.01) Sponsor modeling the alimentary deficiencies / Nikolava OV, Kovaltsova MV, Єvtushenko TG; The applicant is the patent officer Kharkiv National Medical University. - № u 2013 01910; declare 02.18.2013; publ. 25. 06. 2013, Bull. № 12.

Avtandilov GG. Medical morphometry. - M .: Medicine; 1990; 384 p.

Reed Sun. Methods of clinical laboratory research. Mosk-va: Medipress-inform; 2016; 736 p.



  • There are currently no refbacks.

Copyright (c) 2019 © The Author (s) 2019

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski