Anti-inflammatory and antidisbiotic effect of oral biothrit-denta fytogel at orthodontic operations in patients with dentoalveolar anomalies

Mohammed Ali Mehrdad Azari


Background. To determine the condition of the oral cavity in persons with dentoalveolar anomaly after orthodontic operations and the effect on it of oral applications of the Biotrit-Denta phytogel.
Methods. A total of 20 patients with dental-maxillary anomalies and 13 healthy individuals were examined. In unstimulated saliva (oral fluid), the activity of elastase, catalase, lysozyme, urease and the content of malondialdehyde (MDA) were determined. The antioxidant-prooxidant index API was calculated using the ratio of catalase activity and MDA content, and the degree of dysbiosis was calculated using the ratio of relative activities of urease and lysozyme. All 20 patients underwent orthodontic surgery, of this number 10 patients received oral applications of the Biotrit-Denta phytogel for 30 days, the other 10 patients made up the comparison group. After 2 months, the above indicators were determined in all patients in saliva.
Results. An increase in the activity of elastase, urease, the content of MDA and the degree of dysbiosis with a decrease in the activity of catalase and the API index was found in patients with dental-maxillary anomalies. Applications of the phytogel reduced the activity of elastase, urease, MDA content and the degree of dysbiosis, however, they increased the activity of catalase, the API index and showed a tendency to increase the activity of lysozyme. In the comparison group, there were no significant changes in the indicators.
Conclusion. Dentoalveolar anomalies in patients in the oral cavity cause the development of dysbiosis and inflammation, a decrease in antioxidant and immune defense. Oral applications of phytogel "Biotrit-Denta" have antidisbiotic and anti-inflammatory effects.


dentoalveolar anomalies, orthodontics, oral gel, inflammation, dysbiosis

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Kutsevlyak VF, Danilova JuG. The condition of the dental-p system of adolescents and adults with abnormal teeth position. Journ. Education Health Sport. 2015; 5(7): 393-400. (in Russian)

Domenjuk DA, Zelenskij VA, Karsaneva AG [and others]. Assessment of adaptation mechanisms using removable orthodontic equipment in children (atioxidant aspects). Stomatology of child's age and prophylaxis. 2013; 12(4(47): 10-14. (in Russian)

Domenjuk DA, Karsaneva AG, Zelenskij VA. Evaluation of adaptation mechanisms using removable orthodontic equipment in children (immunological aspects). Stomatology of child's age and prophylaxis. 2014; 13(1(48): 35-42. (in Russian)

Sapronova ON, Afinogenov GE, Trezubov VV [and others]. Study of the effectiveness of the antiseptic drug "Argakol" in the treatment of lesions of the oral mucosa of prosthetic etiology. Scientific notes of Acad. I. P. Pavlova. 2010; ХVII(2): 31-33. (in Russian)

Ulitovskii SB. Hygienic prerequisites for the development of gingivitis in children and adolescents undergoing orthodontic treatment. New in stomatology. 2003; 8: 41-42. (in Russian)

Demianenko SA, Morozov AL, Levitsky AP. The effect of antidisbiotic agents on periodontal condition in diabetic rats after orthodontic surgery. Periodontics. 2018; ХХIV(3): 40-43. (in Russian)

Kutsevlyak VF, Danilova JuG. Hardware-surgical treatment of patients with abnormal position of teeth in the pathogenic process. Issues of the day of modern medicine. 2015; 15(3(51): 22-28. (in Russian)

Levitsky AP. Adaptive-trophic systems of the organism and their role in pathology. Announcer of stomatology. 2003; 1: 91-95. (in Russian)

Avdeeva MG, Shubich MG. The pathogenic mechanisms of initiation of syndrome of system inflammatory response (literary review). Clinical laboratory diagnostics. 2003; 6: 3-10. (in Russian)

Pak SG, Grachev SV, Belaia OF [and others]. Pathogenetic aspects of intoxication syndrome in the clinic of infectious diseases. Announcer of the RAMS. 2008;11: 33-41. (in Russian)

Levitsky AP, Makarenko OA, Denga OV [and others]. Phytoadaptogens in the prevention and treatment of dental caries. Odessa, KP OGT, 2013: 119. (in Russian)

Levitsky AP, Makarenko OA, Selivanskaya IA [and others]. The use of mucosal gels in dentistry. Оdеssа, KP OGT, 2012: 20. (in Russian)

Demyanenko SA. Mucoprotective and hepatoprotective properties of wheat germ. Announcer of stomatology. 2008; 5-6: 10-14. (in Russian)

Makarenko OA. How to protect bone tissue. Odessa, KP OGT, 2013: 52. (in Russian)

The "Biotrit-Denta" phytogel RC U 20.4-13903778-032/15:2018 for ТU U 20.4-13903778-032:2012. Hygienic conclusion of the State Service of Ukraine for food safety and Consumer Protection № 602-123-20-2/21388; 14.05.2018. (in Ukrainian)

Azari Mehrdad Mohammad Ali. Periodontoprotective action of oral gel "Biotrit-Denta" in rats with sugar diabetes, received orthodontic treatment. Journal of Education, Health and Sport. 2018;8(8):1186-1192.

Levitsky AP, Makarenko OA, Rossakhanova LN. Salivation in healthy people of different age and in stomatological patients. Announcer of stomatology. 2005; 2: 7-8. (in Russian)

Levitsky AP, Denga OV, Makarenko OA [and others]. Biochemical markers of inflammation of oral cavity tissue: method guidelines. Оdеssа, KP OGT, 2010: 16. (in Russian)

Levitsky AP, Stefanov AV. The methods of the determination of the activity of elastase and its inhibitors: method guidelines. Kiev, GFK, 2002: 15. (in Russian)

Stalnaya ID, Garishvili TG. The method of revelation of malonic dialdehyde with thiobarbituric acid. Moskva, Meditsina, 1977: 66-68. (in Russian)

Gavrikova LM., Segen IT. Urease activity of oral liquid in patients with acute odontogenic infection of maxillo-facial part. Stomatology. 1996; The extra issue: 49-50. (in Russian)

Levitsky AP. Lysozyme instead of antibiotics. Оdеssа, KP OGT, 2005: 74. (in Russian)

Girin SV. The modification of the method of the determination of catalase activity in biological substrates. Laboratory diagnostics. 1999; 4: 45-46. (in Russian)

Levitsky AP, Makarenko OA, Denga OV [and others]. The experimental methods of restoration and estimation of the degree of dysbiosis in oral tissues. Announcer of stomatology. 2010; 2: 22-23. (in Russian)

Truhacheva NV. Mathematical Statistics in biomedical research using application package Statistica. Moscow, GJeOTAR-Media, 2012: 379. (in Russian)



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