The Effectiveness Comparison of Aloe Vera and Nothopanax Sutellarium Extract Toward Thermal Burn on White Rat (Rattus Norvegicus)

Sri Lestari Ramadhani Nasution, Monica Revina, Riski Yuliani, Sri Wahyuni Nasution

Abstract


Thermal burn is depicted as tissue damage which is caused by heat contact, chemical material, electricity and radiation. Several herbal materials that can be used as burn healing are Aloe Vera and Nothopanax Scutellarium. This study is aimed to find out the effectiveness comparison between 50% and 70% concentration on each herbal materials. The sample that used is 30 white rats (Rattus Norvegicus) which is chosen according to the inclusion criteria, and will be divided into 6 groups in which each of groups are given different treatment including: positive control, negative control, 50% formulation of N. scutellarium extract ointment, 75% N. scutellarium, and 50% A. vera. The extract formulation is obtained using maceration method using 96% ethanol solvent, and then the extract will be formulated to be A. vera extract ointment and N. scutellarium with 50% and 75% concentration. The withe rats which given thermal burn treatment will be applied using ointment extract, and it will be left out and observed every three days. Afterward, from the results, the significant will be assessed using ANOVA method. Thus, the results show that A. vera has p = 0,045 and N. scutellarium has p = 0,038 and for both of them are p < 0,05. The T significance then assessed by the result of A. vera extract and N. Scutellarium are p = 0,000 and p < 0,005, respectively. Hence, from the result of assay, the smallest level of burn severity is on N. scutellarium extract, therefore it can be said as the most effective for wound healing with 75 % concentration than A. vera.

Keywords


aloe vera; Nothopanax Sutellarium; thermal burn; ointment.

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References


Moenadjat, Y. Luka Bakar: Masalah dan Tatalaksana. Jakarta: UPK Luka Bakar RS Cipto Mangunkusumo; 2006.

Mitsunaga, Jr J., Gragnani, A., Ramoz, M. Rat an experimental model for burn: a systematic review. Acta Cir Bras, 2012;27(6), 417-423.

Hidayat, T.S.N., Noer, M.S., Saputro, I.D. Five years retrospective study of burns in Dr. Soetomo General Hospital Surabaya. Department of Plastic Reconstructive and Aesthetic Surgery. In Pit Perapi Medan; 2012.

Nielson, et al. Burns: Pathophysiology of Systemic Complications and Current Management. Journal of Burn Care And Research; 2016.

Gauglitz, GG, Korting, HC, Pavicic, T, Ruzucka, T, and Jeschke, MG. Hypertrophic Scarring and Kelloid: Pathomechanisms and Current & Emerging Treatment Strategies. Mol Med, 2011;17(1-2), 113-125.

Lakhanpal G, Bhalerao S, Sharma S et al, (2015). To Study the Efficacy of Different Formulations of Aloe Vera (Spp. Aloe barbadensis) On Wound Healing in Rat. Research Journal of Pharmaceutical, Biological and Chemical Sciences (RJPBCS), 2015;6(4), 432-440.

Nagar, P, Kumar, M. Efficacy of Aloe Vera Gel Dressing In Chronic Leg Ulcer of Diabetic, Traumatic and Burns Origin. Research Journal of Pharmaceutical, Biological and Chemical Sciences (RJPBCS), 2015;6(6), 482-4.

Wim DJ, Sjamsuhidayat, R. Buku ajar ilmu bedah. Jakarta: EGC; 2011.

Hanum, GR, Ardiansyah, S. Sabun Ekstrak Mangkokan (Nothopanax Scutellaium merr) Sebagai Antibakteri Terhadap Staphylococcus Aureus. Stigma Journal of science, 2017;10 (1), 36-39.

Tjahajani, A, Widurini. Aloe vera leaf anti Inflamation’s activity speeds up the healing proccess of oral mucosa ulceration. Journal of Dentistry Indonesia, 2011;18, 17-20.

Yunita, E., Suprapti, N., dan Hidayat, J. Pengaruh Ekstrak Daun Teklan (Eupatorium riparium) terhadap Mortalitas dan Perkembangan Larva Aedes aegypti. Bioma, 2010;11(1), 11-17.




DOI: http://dx.doi.org/10.5281/zenodo.2653313

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