Changes of microelement homeostasis when modeling HIPEC with cisplatine

E. D. Pykhtieieva, A. I. Gozhenko, E. G. Pykhtieieva, D. V. Bolshoy, A. M. Tretyakov

Abstract


HIPEC was simulated on laboratory rats using cisplatin (CP) at a dose of 4 mg/kg. It has been shown that perfusion of a hot and cold solution of CP changes the accumulation of platinum and the concentration of heavy metals in organs (liver, kidney, spleen, blood) in different ways. An acute HIPEC simulation experiment shows that in a fairly short exposure time, critical absorption of platinum into the blood from the abdominal cavity does not occur, although the concentration of platinum in the blood is still growing. At the same time, Pt was found on the surface of parenchymal organs and the peritoneum of rats after the end of the experiment. This platinum is closely related to the surface and is not removed during the washing process. This suggests that the general toxic effect of platinum is less pronounced and delayed than with intravenous administration, but it will certainly occur through further interorgan redistribution.

Keywords


HIPEC, cisplatin, copper, zinc, cadmium, lead, platinum

Full Text:

PDF

References


Belyaeva O. A., Bespalov V. G., Senchik K. Yu., Kireeva G. S., Stukov A. N., Gafton G. I., Karachun A. M., Guseinov K. D., Belyaev A. M. Chemoperfusion treatment of abdominal carcinomatosis. - SPb., 2016. - 146 p. [in Russian]

Portilla D. et al. Cisplatin nephrotoxicity //UptoDate Accessed Oct. – 2017. – С. 1-150.

Assayag, M., Rouvier, P., Gauthier, M., Costel, G., Cluzel, P., Mercadal, L., ... & Bagnis, C. I. (2017). Renal failure during chemotherapy: renal biopsy for assessing subacute nephrotoxicity of pemetrexed. BMC cancer, 17(1), 770.

Floyd, J., Kerr, T. A., & Lindor, K. D. (2016). Chemotherapy hepatotoxicity and dose modification in patients with liver disease. Waltham, MA: UpToDate. Available at: http://www. uptodate. com.

Qian, J., Zhang, X., Zhang, B., Gu, P., Wang, L., & Han, B. (2018). Hepatotoxicity in Advanced Lung Adenocarcinoma: A Retrospective Study of 2108 Cases. Journal of Cancer, 9(9), 1607.

Hurria, A., Togawa, K., Mohile, S. G., Owusu, C., Klepin, H. D., Gross, C. P., ... & Klapper, S. (2011). Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. Journal of Clinical Oncology, 29(25), 3457.

Lichtman, S. M., & Schmader, K. E. (2016). Systemic chemotherapy for cancer in elderly persons.

Bakrin N., Cotte E., Golfier F. et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for persistent and recurrent advanced ovarian carcinoma: a multicenter, prospective study of 246 patients // Ann. Surg. Oncol. – 2012. – Vol. 19. – P. 4052–4058.

Pykhtieieva E.D. Toxic effect of cisplatin with traditional chemotherapy and hyperthermic intraoperative intraperitoneal chemoperfusion (review of literature and own observations) // Actual problems of transport medicine - 2018. - № 3 (53) - P. 19-36. [in Russian]

Miailhe, G., Arfi, A., Mirshahi, M., Eveno, C., Pocard, M., & Touboul, C. (2018). A new animal model for hyperthermic intraperitoneal chemotherapy (HIPEC) in tumor-bearing mice in the treatment of peritoneal carcinomatosis of ovarian origin. Journal of visceral surgery, 155(3), 183-189.

De Visser K. E., Eichten A., Coussens L. M. Paradoxical roles of the immune system during cancer development //Nature reviews cancer. – 2006. – Т. 6. – №. 1. – С. 24.

Vinay D. S. et al. Immune evasion in cancer: Mechanistic basis and therapeutic strategies //Seminars in cancer biology. – Academic Press, 2015. – Т. 35. – С. S185-S198.

Manohar S., Leung N. Cisplatin nephrotoxicity: a review of the literature. J Nephrol. 2018; 31(1):15. Epub 2017 Apr 5.

Skvortsov A.N. The mechanism of cisplatin entry into cells with the participation of the copper transport system: dissertation ... Doctors of Biological Sciences: 03.01.04, 03.01.02 / Skvorcov Aleksey Nikolaevich; [Place of defense: Research Institute of Experimental Medicine, Russian Academy of Medical Sciences]. - St. Petersburg, 2011. - 256 p. [in Russian]

Boulikas T., Vougiouka M. Cisplatin and platinum drugs at the molecular level // Oncol.Rep. – 2003. –10(6). – P. 1663–82.

Osipova T.V., Bukhman V.M. Biomarkers of drug nephrotoxicity / Russian Biotherapeutic Journal // Vol. 14, No. 3, 2015, P. 3-18. [in Russian]

Boulikas T., Vougiouka M. Cisplatin and platinum drugs at the molecular level // Oncol.Rep. – 2003. –10(6). – P. 1663–82.

Age Peculiarities of the Condition of the Renal Functional Reserve in Intact Rats / A. I. Gozhenko, S. I. Dolomatov, L. V. Romaniv [and others] // Clinical and Experimental Pathology. - 2005. - Vol. 4, No. 3. - pp. 42–45. [in Russian]

Gozhenko A.I. Functional renal reserve: physiological significance of functional renal reserve and substantiation of the method of its determination / AI Gozhenko, AV Kravchuk, V. M. Sirman, O. P. Nikitenko, L. V. Romanov / / Kidney. - 2015. - No. 4. - P. 7-11. [in Ukrainian]

Kozinets G.I. Interpretation of blood and urine tests and their clinical significance. - M .: "Triad-X", 2000. - 103 c) [in Russian]




DOI: http://dx.doi.org/10.5281/zenodo.2652041

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 © The Author (s) 2019

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)