Exposure to hydrogen peroxide – under the toxicologist eye

Grzegorz Boreński, Magdalena Wójcik, Julita Poleszak, Przemysław Szabat, Marta Szabat, Michał Tchórz, Jarosław Szponar

Abstract


Introduction: Hydrogen peroxide is well soluble, odourless and colourless liquid with syrup consistency. It has different application depending on concentration. In 3% of concentration is present in almost every home as a disinfectant product, in higher concentration (35%) is used in pharmaceutical, chemical and cosmetic industry.
The aim of the study: The purpose of this systemic review was to collect and analyse causes and possibilities of treatment a patient after ingestion a caustic substance.
Material and method: Standard criteria were used to review the literature data. The search of articles in the PubMed and Google Scholar database was carried out using the following keywords: hydrogen peroxide, exposure, toxicology.
Description of the state of knowledge: Exposure for hydrogen peroxide is not very common and most of the times is unintentional, except suicide attempts. Because it is a caustic substance and the main route of exposure is ingestion, most of symptoms are due to damage of gastrointestinal tract. However, the consequences of exposure range from short-time illness to brain damage or even death.
Summary: Patient after exposure to >30% hydrogen peroxide should receive a complex treatment. Physicians need to be alert to the symptoms of not only gastrointestinal tract but also CNS. The patient may require specialized care by many specialists.

Keywords


hydrogen peroxide; exposure; toxicology

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References


Ijichi T, Itoh T, Sakai R, Nakaji K, Miyauchi T, Takahashi R, et al. Multiple Brain Gas Embolism After Ingestion of Concentrated Hydrogen Peroxide. Neurology. 1997; 48(1): 277-279.

Hydzik P. Substancje żrące [caustic substance]. In: Pach J, editor. Zarys toksykologii klinicznej [Outline of clinical toxicology]. Kraków, Wydawnictwo Uniwersytetu Jagiellońskiego; 2009: 523-534. in Polish.

Dickson K.F., Caravati E.M. Hydrogen peroxide exposure - 325 exposures reported to a regional poison control center. J. Toxicol. Clin. Toxicol. 1994; 32(6): 705-714.

Henry MC, Wheeler J, Mofenson HC, Caraccio TR, Marsh M, Comer GM, et al. Hydrogen peroxide 3% exposures. J. Toxicol. Clin.Toxicol. 1996; 34: 323-327.

Pritchett S, Green D, Rossos P. Accidental ingestion of 35% hydrogen peroxide. Can J Gastroenterol. 2007; 21(10): 665-667.

Watt BE, Proudfoot AT, Vale JA. Hydrogen Peroxide Poisoning. Toxicol Rev. 2004; 23(1): 51-57

Ciechanowicz R, Sein Anand J, Chodorowski Z, Kujawska-Danecka H. Acute intoxication with hydrogen peroxide with air emboli in central nervous system - a case report. PrzeglLek. 2007; 64(4-5): 339-340.

Pawar D, Calara A, Jacob R, Beck N, Peiris AN. Hydrogen Peroxide Induced Colitis: A Case Report and Literature Review. Case Rep Gastrointest Med. 2017; 6432063.

Taş A, Aydın YY, Arhan M, Köklü S. Hydrogen peroxide exposure mimicking ulcerative proctitis. Dig Liver Dis. 2011; 43(4): 331-332

Bilotta JJ, Waye JD. Hydrogen peroxide enteritis: the “snow white” sign. GastrointestEndosc. 1989; 35(5): 428-430.

B. Lapeyre. The “Frost Sign” and the “Snow White Sign”: Intramucosal Air Injection or Peroxide Colitis?. Endoscopy. 2005; 37(7): 679.

Chung, J, Jeong M. Oxygen embolism caused by accidental subcutaneous injection of hydrogen peroxide during orthopedic surgery: A case report. Medicine. 2017; 96(43): e8342.

Bartosz G. Uszkadzanie składników komórkowych przez reakthywne formy tlenu [Damaging cellular components by reactive oxygen species]. In: Bartosz G, editor. Druga twarz tlenu [The second face of oxygen]. Warszawa, Wydawnictwo Naukowe PWN; 2006: 99-119. in Polish.

Ostrea EM Jr, Cepeda EE, Fleury CA, Balun JE. Red Cell Membrane Lipid Peroxidation and Hemolysis Secondary to Phototherapy. ActaPaediatrica. 1985; 74(3): 378–381.

Marnett LJ. Mutation research. 1999; 424(1-2): 83–95.

Contini S, Scarpignato C. Caustic injury of the upper gastrointestinal tract: a comprehensive review. World J Gastroenterol. 2013; 19(25): 3918-3930.

Lee JS, Yoo JK. Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review. Environ Health Toxicol. 2018; 33(1): e2018005.

Gupta SK, Croffie JM, Fitzgerald JF. Is esophagogastroduodenoscopy necessary in all caustic ingestions?. J PediatrGastroenterolNutr. 2001; 32(1): 50-53.

De Lusong M, Timbol A, Tuazon D. Management of esophageal caustic injury. World J GastrointestPharmacolTher. 2017; 8(2): 90-98.

Cheng HT, Cheng CL, Lin CH, Tang JH, Chu YY, Liu NJ, et al. Caustic ingestion in adults: the role of endoscopic classification in predicting outcome. BMC gastroenterology. 2008; 8: 31

Keh SM, Onyekwelu N, McManus K, McGuigan J. Corrosive injury to upper gastrointestinal tract: Still a major surgical dilemma. World J Gastroenterol. 2006; 12(32): 5223-5228.

Hawkins DB, Demeter MJ, Barnett TE. Caustic ingestion: controversies in management. A review of 214 cases, Laryngoscope. 1980; 90(1): 98-109.

Demirbilek S, Aydin G, Yücesan S, Vural H, Bitiren M. Polyunsaturated phosphatidylcholine lowers collagen deposition in a rat model of corrosive esophageal burn. Eur J Pediatr Surg. 2002; 12(1): 8–12.

Günel E, Cağlayan F, Cağlayan O, Canbilen A, Tosun M. Effect of antioxidant therapy on collagen synthesis in corrosive esophageal burns. PediatrSurg Int. 2002; 18: 24–27.

Welsh JD, Griffiths WJ, McKee J, Wilkinson D, Flournoy DJ, Mohr JA. Bacteremia associated with esophageal dilatation. J Clin Gastroenterol. 1983; 5(2): 109-112.

Wu MH, Lai WW. Surgical management of extensive corrosive injuries of the alimentary tract. SurgGynecol Obstet. 1993; 177: 12–16.

Brun JG, Celerier M, Koskas F, Dubost C. Blunt thorax oesophageal stripping: an emergency procedure for caustic ingestion. Br J Surg. 1984; 71: 698–700.




DOI: http://dx.doi.org/10.5281/zenodo.2639230

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