The performed analyses of incidence rate of testicular germ cell tumors and clinical and pathologic analysis, based on the examination of pathologists’ reports and medical case histories of the patients of Kharkiv regional clinical center of urology and nephrology named after Shapovalov V.I., for the period covering years 1998-2017, revealed: unfavorable increasing tendency in testicular GCT incidences, the most typical age of patients with mentioned pathology, and average duration of the disease by the time the patient visited the doctor; determined the possible risk factors of testicular GCT development, as well as the morphological traits in accordance with WНO updated classification.

testicular germ cell tumors, clinical and pathologic characteristics, pTNM classification

Trabert B. International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973-2007 / B. Trabert, J. Chen, S.S. Devesa, F. Bray, K.A. McGlynn // Andrology. – 2015. – V. – 3. – P. 4–12.

Oosterhuis J.W. Testicular germ-cell tumors in a broader perspective / J.W. Oosterhuis, L.H. Looijenga // Nat. Rev. Cancer. – 2005. – V. 5. – P. 210–222.

Stang A. Gonadal and extragonadal germ cell tumors in lhe United States, 1973-2007 / A. Stang, B. Trabert, N. Wentzensen, M.B. Cook, C. Rusner, J.W. Oosterhuis // Int. J. Andrei. – 2012. – V. 35. – P. 616–625.

Huyghe E. Increasing incidence of testicular cancer worldwide: a review / E. Huyghe, T. Matsuda, P. Thonneau // J. Urol. 2003. – V. 170, № 1. – Р. 5–11.

Bray F. Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality / F. Bray, L. Richiardi, A. Ekbom, E. Pukkala, M. Cuninkova, H. Möller // Int. J. Cancer. – 2006. – V. 118. – P. 3099–3111.

Statistics on oncological diseases in Ukraine [Electronic resource]. – access mode: http://uozter.gov.ua/ua/news-1-21-223-statistika-onkologichnih-zahvoryuvan-v-ukraini

WHO Сlassification of Tumors of the Urinary System and Male Genital Organs, In: Eble Holger Moch, Peter A. Humphrey, Thomas M. Ulbright, Victor E. Reuter. Lyons: IARC Press, 2016: 218, P. 184–258.

Purysko A.S. Radiologic imaging of patients with bladder cancer / A.S. Purysko, H.M. Leao Filho, B.R. Herts // Semin. Oneal. – 2012. – V.39. – Р. 543–558.

Cook M.B. A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer-еxperiences of the molher / M.B. Cook, О. Akre, D. Forman, M.P. Madigan, L. Richiardi, K.A. McGlynn // Int. J. Epidemiol. – 2009. – V. 38.– р. 1532–1542.

Cook M.B. A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer-experiences of the son / M.B. Cook, О. Akre, D. Forman, M.P. Madigan, L. Richiardi, K.A. McGlynn // Int. J. Epidemiol. – 2010. – V.39. – р. 1605–1618.

Albers P., Albrecht W., Algaba F. еt al. Guidelines on Testicular Cancer // Europ. Urol. – 2005. – V. 48. – P. 885–894., Dohle G.R., Colpi G.M., Hargreave T.B. et al. EAU Guidelines on Male Infertility // Europ. Urol. – 2005. – V. 48. – P. 703–711.

Rijlaarsdam M.A. An oncofetal and developmental perspective on testicular germ cell cancer / M.A. Rijlaarsdam, L.H. Looijenga // Semin Cancer Biol. – 2014. – V. 29 – P. 59–74.

van der Zwan Y.G. Gonadal maldevelopment as risk factor for germ cell cancer: towards a clinical decision model / Y.G. van der Zwan, K. Biermann, K.P. Wolffenbutlel, M. Cools, L.H. Looijenga // Eur Urol. – 2015. – V. 67. – P. 692–701.

Henderson B.E. Estrogens as a cause of human cancer / B.E. Henderson, R. Ross, L. Bernstein // Cancer Res. – 1988. – V. 48. – Р. 246-253.

Dieckmann K.P. Is risk of testicular cancer related to the body size? / K.P. Dieckmann, U. Pichlmeier // Eur. Urol. – 2002. – V. 42, №6. – Р.564–569.