The place of the endothelial component in the pathogenesis of influenza A

A. I. Vereschagina, E. V. Nikitin

Abstract


Influenza A viruses are genetically diverse and the most unpredictable variable pathogens. It is a dangerous and poorly managed infection, able to reassort, with a high probability of developing urgent conditions, complications and death at any age. The objective: to determine the diagnostic value of CEC in influenza A. Materials and methods: There were 158 influenza A patients included in the survey presented. Observation period - 2015-2018. The 1st group included 32 patients with a mild flu course, the 2nd group - 62 patients with moderate flu, and the 3rd group - 64 patients with a severe flu and mild pneumonia. The severity was determined by clinical manifestations and the presence of complications. Exclusion criteria from the study: age under 18 and over 45 y.o., pregnancy and severe somatic pathology. The control group consisted of healthy volunteers - 30 persons, similar in sex and age with a patient’s group. Conclusions. It was established that endothelium damage occurs even at mild course of influenza A. Severe influenza infection is accompanied by a massive endothelial damage with the development of endothelial dysfunction. Determination of circulating endothelial cells in blood is a simple and reliable indicator of the disease severity and its complications development.

Keywords


influenza A, endothelial dysfunction, desquamated endotheliocytes

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References


Azaronak A. The role of influenza virus and the surface proteins in the development of endothelial dysfunction: Synopsis of the candidate’s thesis on biol. sciences: spec. 3.2.02.- SPb., 2014.- 29 p.

Vyunitskaya L. V. Markers of endothelial dysfunction. Laboratory diagnosis. Eastern Europe. 2015. № 3 - 4 (15-16). P. 37 - 51.

Duda A. K, Dubrovsky E. I Influenza and other acute respiratory viral infections: clinical features, complications and treatment optimization. Family medicine. 2014. № 6 (36). P. 127-134.

Kartopolova Ye. V., Ratnikova L. I. Etiological and pathogenetic features of modern influenza (analytical review of scientific literature. Proceedings of higher educational institutions. Ural region. 2016, No. 2. P. 143-147.

Malyarchikov AV, Shapovalov KG state of microcirculation in patients with severe influenza A / H1N1. The doctor-graduate student. 2013. № 1 (56). P. 61–167.

Damage to the endothelium in patients with pneumonia during the pandemic of influenza A (H1N1) and the possibility of its correction [Electronic resource] / V.V. Gorbunov, SA Lukyanov, A.V. Govorin, EN Romanova [et al.] // Zabaikal'skii Medical Bulletin. - 2011. - №2. – P. 104 - 111. Access mode: http://medacadem.chita.ru/zmv2.

The state of the function of the vascular endothelium in infectious diseases of various etiologies / Loktionova I.L., Pokrovsky M.V., Ragulina V.A. and others. Scientific statements. Series Medicine. Pharmacy. 2012. № 4 (123). Issue 17/1. Pp. 20-31.

Armstrong S. M., Darwish I., Lee W. L. Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection. Virulence. 2013. Vol. 4, № 6. P. 537–542. doi: 10.4161/viru.25779

Barik S. New treatments for influenza. BMC Med. 2012. № 10. P. 104. doi: 10.1186/1741-7015-10-104

Endothelial Cell Metabolism / G. Eelen, P. de Zeeuw, L. Treps et al. Physiol. Rev. 2018. Vol. 98, № 1. P. 3–58. doi: 10.1152/physrev.00001.2017

Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection / J. R. Teijaro, K. B. Walsh, S. M. Cahalan et al. Cell. 2011. Vol. 146, № 6. P. 980–991. doi: 10.1016/j.cell.2011.08.015

Hladovec J. Circulating endothelial cells as a sign of vessel wall lesions. Physiol. Bohemoslov. 1978. Vol. 27, № 2. Р. 140-144.

The Assessment of Endothelial Function – From Research into Clinical Practice / A. J. Flammer, T. Anderson, D. S. Celermajer et al. Circulation. 2012. Vol. 126, № 6. P. 753–767. doi: 10.1161/CIRCULATIONAHA.112.093245

Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art / M. Radenković, M. Stojanović, T. Potpara, M. Prostran. Biomed. Res. Int. 2013. 2013: 252158. doi: 10.1155/2013/252158.




DOI: http://dx.doi.org/10.5281/zenodo.2617172

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