Possibilities of pathogenetic correction of hyperkinetic disorders taking into account an acid-base balance

V. N. Hertsev, A. N. Stoyanov, T. N. Muratova, R. S. Vastyanov, E. A. Kolesnik


As a result of analysis of the available scientific data, a significant relationship between hyperkinetic syndromes and changes in the acid-base state has been revealed. The provoking effect of alkalosis on the occurrence and severity of hyperkinetic disorders was confirmed. An own example of effective treatment of patient with essential myoclonus with taking in account his acid-base state has been given. The addition of acetylsalicylic acid to the treatment with clonazepam caused a more significant decrease in the severity of hyperkinetic disorders and improved the patient’s general condition and his quality of life. So that we suggest studying of acid-base balance in patients with hyperkinetic syndromes and syndrome of increased neuromuscular excitability in the outpatient setting and in hospital conditions at the making of initial diagnosis, and also recommend studying of acid-base balance in patients who already have neurological diagnoses, if such a study has not been made previously. Correction of acid-base status in the treatment of patients with hyperkinetic syndromes and the syndrome of increased neuromuscular excitability contributes to greater effectiveness of therapy than just symptomatic treatment of hyperkinetic disorders.


acid-base balance, alkalosis, essential myoclonus, hyperkinetic disorders

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Vercueil, L. Myoclonus and movement disorders. Neurophysiol. Clin. 2006, 36, 327–331.

Abdo, W.F.; van de Warrenburg, B.P.; Burn, D.J.; Quinn, N.P.; Bloem, B.R. The clinical approach to movement disorders. Nat. Rev. Neurol. 2010, 6, 29–37

Caviness JN. Myoclonus. Mayo Clin Proc 1996; 71(7): 679-88.

Richard K. Disorders of movement and Imbalance. Harrison’s, Principles of Internal Medicine, 16th Ed ; McGraw-Hill Medical Publication Division 2005; 139.

Allen CMC, Lueck CJ, Dennis M. Neurological Disease. Davidson’s Principles & practice of medicine; 20th Ed. Churchill Livingstone 2005;1182.

Charles RA. Neurological Disease. Kumar and Clark: Clinical Medicine: 6th Ed; Elervier Saunders 2005; 1232

Patofiziologiya : uchebnik [Pathophysiology]: v 2 t. / pod red. V.V. Novitskogo, Ye.D. Gol'dberga, O.I. Urazovoy. - 4-ye izd., pererab. i dop. - GEOTAR-Media, 2009. - T. 1. - 848 s. : il. (in Russian)

Patofiziologiya: uchebnik [Pathophysiology]: v 2 t. / pod red. V.V. Novitskogo, Ye.D. Gol'dberga, O.I. Urazovoy. - 4-ye izd., pererab. i dop. - GEOTAR-Media, 2009. - T. 2. - 640 s. : il. (in Russian)

Litvitskiy, P.F. Patofiziologiya [Pathophysiology]. V 2 t. - 5-ye izd., pererab. i dop. – M.: GEOTAR-Media, 2016. – 624s. (in Russian)

Brinkman JE, Sharma S. Physiology, Alkalosis, Respiratory. [Updated 2018 Jan 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482117/

John H. Galla. Metabolic Alkalosis J Am Soc Nephrol 11: 369–375, 2000

Zhang S, Sun P, Sun Z, Zhang J, Zhou J, Gu Y. Cortical GABAergic neurons are more severely impaired by alkalosis than acidosis. BMC Neurology. 2013;13:192. doi:10.1186/1471-2377-13-192.

Bennett JC. In: Cecil Textbook of Medicine. Bennett JC, Plum F, editor. Philadelphia: W. B. Saunder Co; 1996.

Acid–base Disturbances. DuBose TD. In: Harrison’s Principles of Internal Medicine. Fauci AS, editor. New York: McGraw-Hill; 1997.

Acidosis and Alkalosis. Okuda T, Kurokawa K, Papadakis MA. In: Current Medical Diagnosis & Treatment. Tierney LM, McPhee SJ, Papadakis MA, editor. Stamford: Appleton & Lange; 1998. Fluid and Electrolyte Disorders; pp. 824–849.

Nowak TJ, Handford AG. In: Fluid and Electrolyte Imbalances., in Pathophysiology. Nowak TJ, Handford AG, editor. Boston: Martin J. Lange; 2004. pp. 422–445.

Fraley DS, Adler S, Bruns F. Life-threatening metabolic alkalosis in a comatose patient. South Med J 72: 1024–1025, 1979

Adachi M, Ikemoto Y, Kubo K, Takuma C. Seizure-like movements during induction of anaesthesia with sevoflurane. Br J Anaesth 68: 214–215, 1992.

Victor M. The role of hypomagnesemia and respiratory alkalosis in the genesis of alcohol-withdrawal symptoms. Ann N Y Acad Sci 215:235– 248, 1973

P Simons, I Nadra, P G McNally Metabolic alkalosis and myoclonus Postgrad Med J 2003;79:414–415

Okada K, Kono N, Kobayashi S, et al. Metabolic alkalosis and myoclonus from antacid ingestion. Internal Medicine 1996;35:515–6

Ishiguchi T, Mikita N, Iwata T, Nakata H, Sato H, Higashimoto Y, Fujimoto H, Yoshida S, Itoh H. Myoclonus and Metabolic Alkalosis from Licorice in Antacid Internal Medicine 43: 59–62, 2004

Kaye M, Somerville PJ, Lowe G, et al. Hypocalcaemic tetany and metabolic alkalosis in a dialysis patient: an unusual event. Am J Kidney Dis 1997;30:440–4.

Westerblad H, Allen DG. Mechanism underlying changes of tetanic [Ca2+]i and force in skeletal muscle. Acta Physiol Scand 1996;156:407–16.

Ryland P Byrd . Respiratory Alkalosis. Apr 24, 2014. https://emedicine.medscape.com/article/301680-differential

DuBose TD, Jr. Acidosis and Alkalosis. Kasper DL, Braunwald E, Fauci AS, Hauser Sl, Longo DL, Jameson JL,eds. Harrison's Principles of Internal Medicine. 16th. New York, NY: McGraw-Hill; 2005. 270-1.

Gardner WN. The pathophysiology of hyperventilation disorders. Chest. 1996 Feb. 109(2):516-34.

Effros RM, Wesson JA. Acid-Base Balance. Mason RJ, Broaddus VC, Murray JF, Nadel JA, eds. Murray and Nadel's Textbook of Respiratory Medicine. 4th ed. Philadelphia, PA: Elsevier Saunders; 2005. Vol 1: 192-93.

Adrogue HJ, Madias NE: Management of life-threatening acidbase disorders. N Engl J Med 338: 107–111, 1998

Phillipson EA, Duffin J. Hypoventilation and Hyperventilation Syndromes. Mason RJ, Broaddus VC, Murray JF, Nadel JA, eds. Murray and Nadel's Textbook of Respiratory Medicine. 4th ed. Philadelphia, PA: Elsevier Saunders; 2005. Vol 2: 2069-70, 2080-84.

Goldman A. Clinical tetany by forced respiration. JAMA. 1922. 78:1193-95.

Haldane JS, Poulton EP. The effects of want of oxygen on respiration. J Physiol. 1908. 37:390-407.

Anderson LE, Henrich WL Alkalemia-associated morbidity and mortality in medical and surgical patients. South Med J. 1987 Jun; 80(6):729-33.

Swagata Tripathy. Extreme metabolic alkalosis in intensive care. Indian J Crit Care Med. 2009 Oct-Dec; 13(4): 217–220.

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