Expermental research of the effects of benofilin on the functional renal function in the evalution of ethylene glycol toxic loss

O. P. Matviychuk, A. V. Matviychuk, A. V. Taran

Abstract


Effect of benofilin – a new compound among a new derivative of theophylline and hofitol (70 mg/kg) on functional renal function was studied based on the rat experimental model of acute kidney damage by ethylene glycol. The toxic products of the metabolism of ethylene glycol cause renal tubular damage resulting in acute renal failure (ARF). As a result of the application of benofilin its ability is established to prevent the death of animals in the first day of the experiment. By the ability to prevent impaired kidney function in rats benofilin exceeds the effect of the hofitol.

Keywords


benofilin, acute kidney damage, diuretic, nephroprotective activity, rats

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References


Darmon M. Acute renal failure. Intensive Care Medicine Volume 41, Issue 5 May 2015. P. 875–886

European convention for the protection of the vertebrate animals used for experimental and other scientific purposes: Council of Europe 18.03.1986. Strasbourg, 1986. 52 p.

Kamyshnikov V. C. Clinical-biochemical laboratory diagnoctics. Correspondent: In 2 t., T. 1st / 2nd ed. Мn .: Intеrреssеrvise. 2003. 495 c.

Kornienko V.I. The search and development of a means for pharmacological correction of nephropathy and cardiopathy among n-c-8-substituted and condensed xanthine derivatives: diss. for obtaining a degree in biological sciences. Sciences: 14.03.05 / Kharkiv. 2016. 316 p.

Krasyuk I.V. Influence of progression of chronic kidney disease on quality of life indicators. Ukr Journal of Nephrology and Dialysis. 2015. No. 2 (46). P. 37-41.

Lapach S.N., Chubenko A.V., Babich P.N. Statistical methods in medical and biologic research using EXCEL. Ed. 2nd, Pererab. and add. K .: Morion. 2001. 408 p.

Mashkovsky M.D. Medicinal products / ed. 16th, revised. and dop. M .: RIA Novaya volnna. 2010. 1216 p.

Maslova N.F, Shevina V.L., Barshchevskaya M.I. Comparative evaluation of the pharmacological action of the drug URONEFRON in two dosage forms: tablets and drops. Phytotherapy.Chaspus. 2017. Number 2. P.32-36.

Matviychuk O. P., Taran AV. Investigation of nephroprotective action of a new substance among derivatives of 7,8-dispersed theophylline. Information letter to Ukrmedpatentinform of the Ministry of Health of Ukraine No. 183-2017. K., 2017. 3 p.

Medical laboratory technologies: a handbook. In 2 t. T. 1 / ed. A.I. Karpishchenko. SPb: Intermedika. 2002. 408 s.; V. 2 / ed. A.I. Karpishchenko. SPb: Intermedika. 2002. 600 p.

Merzon, A. K., Titarenko, O. T., Andreeva, E. K. Comparative Evaluation of Methods of Chemical Indication of Creatinine. Laboratories delo. 1970. No. 7. P. 416–418.

Method for determining the activity of catalase / M.A. Korolyuk, L.I. Ivanova, I.G. Mayorova, V.E. Tokarev. Laboratory cause. 1988. No. 1. P. 16–19.

Methods of experimental modeling of kidney damage for pharmacological research: method. rekom DFU of Ukraine / C. Yu. Strygol, V. M. Lycowii, I. A. Zupanets [et al]. K. 2009 P. 9-10.

Mikheeva A.I., Bogodarova I.A. On the method of determining total protein in a bottle on FEC – H – 56. Laboratories delo. 1969. No. 7. P. 441–442.

Mukhin, H. A., Tareeva, I. Ye., Shilov, E. M. Diagnosis and treatment of painful kidneys. M .: Geotar-Media. 2008. 384 p.

Natochin Yu. V. Physiology of the kidney: formulas and calculations. L.: Science. 1974. 60 c.

Nephroprotection by theophylline in patients with cisplatin chemotherapy: a randomized, single-blinded, placebocontrolled trial / P. Benoehr, P. Krueth, C. Bokemeyer [et al.]. Journal Am Soc Nephrol. 2005. Р. 452–458.

Nikolaev A.Yu. Advantages and disadvantages of a nephroprotective strategy (literature review). Attending doctor. 2014. No. 8. P. 15–18.

Osswald H., Schnermann J. Methylxanthines and the kidney. Handb.Exp.Pharmacol. 2011. Vol. 16. P. 391–412.

Shtrygol S. Yu., Arakelyan N. G. Acute renal failure: developmental mechanisms and experimental models. Zaporizhzhya honey. journals 2005. V. 32. No. 5. P. 150–155.

Shtrygol S. Yu., Tovchiga O. V. Biologically active substances and preparations of plant origin with nephroprotective activity. Farmakom 2010. No. 1. P. 140–155.

Shyuk O. T. Functional study of the kidneys. Prague: Avicenum. 1981. 344 p.

Smirnov A.V., Kayukov I.G., Dobravravov V.I. Necrosis of the kidneys - a new insight in the nephrosis. Clinical nephrosis. 2016. № 1. P. 11–15.




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