Dynamics of hematological parameters in patients with HRTB/HIV with levels of CD4+lymphocytes 200-50 cells/μl in imunoglobulin therapy application
Abstract
The purpose and tasks of the study. To study the hematologic changes in patients co-infected HRTB / HIV at the level of CD4 + lymphocytes 200 - 50 cells/ml and evaluate the effectiveness of immunoglobulin therapy.
Materials and methods. The study involved 52 patients with combined HRTB / HIV disease, aged 20 to 55 years. The study of hematological parameters was performed on the basis of the laboratory of the Odessa regional anti-tuberculosis dispensary, the calculation was performed on the automatic hematological analyzer Sysmex ХР-300 3-diff with direct counting of neutrophils (Japan).
Results and discussion. In patients with HRTB / HIV with a level of CD4 + lymphocytes below 200 cells / μl, hematological parameters before the start of anti-TB therapy were characterized by the fact that patients of both groups were more likely to have leukocytosis than leukopenia, that is: 3.5 times more often in patients in group 1 (26.9% vs. 7.7%), and 9.1 times in the 2nd group (34.6% vs. 3.8%); lymphopenia - 2 times higher than lymphocytosis in group 1 and the same expressed in group 2 (see table). Monocytopenia was noted in 3.8%, monocytosis was registered 4 times more often in group 1, and in 1.5 times - in the 2nd. The frequency of eosinophilia reached 15.4% and 11.5%, in the first and second groups, respectively. Increases in neutrophils occurred in 30.8% and 38.5% of patients in groups 1 and 2, respectively.
Lung anemia was registered more often in both groups than anemia of average grade - 2 times more often in the 1 st (46.2% vs. 23.1%), and the second group (53.8% vs. 26.9%) , and severe anemia was 3.8% in the 1st group and 7.7% in the second group of the subjects.
Thrombocytopenia was diagnosed in 23.1% and 19.2% of patients in groups 1 and 2. Increasing the rate of erythrocyte sedimentation was determined in a greater number of patients - 69.2% of the examined group 1 and 65.4% of the 2nd group.
Conclusions. After the use of intravenous IgG in the combination therapy of patients with HRTB/HIV, there was a significant reduction in the manifestations of inflammation and infectious activity compared with patients taking only anti-TB drugs and ARVT according to treatment standards.
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DOI: http://dx.doi.org/10.5281/zenodo.2567547
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