Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde

Elena Prokopchuk, Alexandra Aleksandrova, Iryna Kravchenko

Abstract


The physiological role of pain helps to avoid or limit the tissue damage and therefore it provides the vital protective function. It has been previously studied, that complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde as well as their components represent the practical interest by the manifestation of anti-inflammatory and antidepressive action. In this case the analgesic properties of the complexes themselves, as well as compounds belonging to their structure were of interest of our study. The experiments were performed on white mice. Several chemical (allyl isothiocyanate or AITC, capsaicin, formalin) and thermal effects have been chosen in this investigation for studying the analgesic activity and establishing the possible mechanisms of antinociceptive effect.
The tested compounds showed a mixed type of receptor interaction using models with different types of stimulation, which allows to make conclusions about their perspective as highly effective analgesics with a complex mechanism of action.

Keywords


anti-inflammatory; AITC; stannous chloride; salicyloylhydrazones; brombenzaldehyde; benzaldehyde

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References


Merskey H, Bugduk N. Classification of Chronic Pain. Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms. 2nd ed. Seattle, WA: IASP Press; 1994.

Helms J, Barone C. Physiology and Treatment of Pain. Crit Care Nurse. 2008: 28: 38–49.

Riesner HJ, Zeitler C, Schreiber H, Wild A. Additional treatment in chronic pain syn- drome due to hip and knee arthritis with the selective serotonin reuptake inhibitor fluvoxamine (Fevarin). Z Orthop Unfallchir. 2008: 146: 742-6.

Schreiber S, Pick CG. From selective to highly selective SSRIs: a comparison of the antinociceptive properties of fluoxetine, fluvoxamine, citalopram and escitalopram. Eur Neuropsychopharm. 2006: 16: 464-8.

Shmatkova NV, Seifullina II, Aleksandrova АI, Polishchuk АV. The complexes [Tetrechlorido-(N-4-R-benzylidenesalicyloylhydrazinato-N,O)tin(IV)] (R=OCH3, Br, N(CH3)2 and their anti-inflammatory activity. ONU Herald Chem. 2013: 18: 16-24. (in Russian)

Alexandrovа ОI, Kravchenko IA, Prokopchuk ОG, et al. Anticonvulsant and antidepressant activity of new complexes of Sncl4 with salicyloylhydrazones of benzaldehyde and 4-brombenzaldehyde by oral administration. Odes Med J. 2015: 5: 24-7. (in Ukrainian)

Abelev GI. Inflammation. Soros Ed J. 1996: 10: 28-32. (in Russian)

Weirich EG, Longauer JK, Kirkwood AH. Dermatopharmacology of salicylic acid. III. Topical contra-inflammatory effect of salicylic acid and other drugs in animal experiments. Dermatologica. 1976: 152: 87-99.

Draelos ZD. Salicylic acid in the dermatologic armamentarium. Cosmet Derm. 1997: 10: 7–8.

Uppal G, Bala S, Kamboj S, Saini M. Therapeutic review exploring antimicrobial potential of hydrazones as promising lead. Der Pharma Chem. 2011: 3: 250-68.

Rollas S, Küçükgüzel SG. Biological activities of hydrazone derivatives. Molecules. 2007: 12: 1910-39.

European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Council of Europe, Strasbourg. 1986. No123. 51p.

Reznikov OG. General Principals of Experiments on Animals. Endokrynologia. 2003: 8: 142-5. (in Ukrainian)

Stefanov OV. Doklinichni doslidzhennia likarskykh zasobiv [Preclinical studies of drugs], methodological recommendations. MOZ Ukraiiny, Derzhavnyi farmakolohichnyi tsentr [Ministry of Health of Ukraine. State Pharmacological Center], Kyiv. 2001, 527 p. (in Ukrainian)

Khabriev RU. Rukovodstvo po eksperementalnomu (doklinicheskomu) izucheniiu novykh farmakologicheskikh veshchestv [Manual on experimental (preclinical) study of new pharmacological substances]. Meditsina [Medicine], Moscow. 2005: 832 p. (in Russian)

Tjølsen A, Berge OG, Hunskaar S, et al. The formalin test: an evaluation of the method. Puin. 1992: 51: 5-17.

Hunskaar S, Berge OG, Hole K. A modified hot-plate test sensitive to mild analgesics. Behav Brain Res. 1986: 21: 101-8.

Mironov AN. Rukovodstvo po provedeniiu doklinicheskikh issledovanii lekarstvennykh sredstv. Chast I [Guidelines for pre-clinical trials of drugs. Part I]. Grif I K, Moscow. 2012: 944 p. (in Russian)

Lavich TR, Cordeiro RS, Silva PM, Martins MA. A novel hotplate test sensitive to hyperalgesic stimuli and nonopioid analgesics. Braz J Med Biol Res. 2005: 38: 445-51.

Hatakeyama Y, Takahashi K, Tominaga M, et al. Polysulfide evokes acute pain through the activation of nociceptive TPRA1 in mouse sensory neurons. Mol Pain. 2015: 11: 24.

Lumpkin EA, Caterina MJ. Mechanisms of sensory transduction in the skin. Nature. 2007: 445: 858-65.

Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain. 1987: 30: 103-14.

Shmatkova NV, Seifullina II, Alexandrova AI, et al. About new complexes tin (iv) with 5-brom salicyloylhydrazones of substituted of benzaldehyde. ONU Herald Chem. 2013: 18: 53-60. (in Russian)

Valdman AV, Ignatov YD. Tsentralnye mekhanizmy boli [Central mechanisms of pain]. Nauka, Leningrad. 1976.




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