The expression level of the CLDN14 gene in patients with urolithiasis - a preliminary report

Diana Słota, Tadeusz Paweł Wasilewski, Mariusz Goniewicz, Klaudia Długoborska

Abstract


Summary
Aim: An attempt to assess the expression of the CLDN14 gene at the mRNA level in patients diagnosed with urolithiasis in relation to healthy persons constituting a comparative group.
Material and methods: The material for examinations was peripheral blood from 23 patients, including 12 women and 11 men with diagnosed kidney stones disease and 6 donors (control group), including 2 women and 4 men who did not have kidney stones.
Results and conclusions: The studies showed differences in the level of CLDN14 gene expression in both the examined and the comparative group.

Key words: CLDN14, gene expression, urolithiasis

Keywords


CLDN14, g;ne expression; urolithiasis

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References


Hewitt K.J., Agarwal R., Morin P.J.: The claudin gene family: expression in normal and neoplastic tissues. BMC Cancer, 2006, 6 (186)

Thorleifsson G. i współ.: Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density. Nature Genetics, 2009, 41 (8).

Furuse M., Sasaki H., Fujimoto K., Tsukita S.: A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell. Biol., 1998, 4.

Yamazaki Y., Tokumasua R., Kimurab H., Tsukitaa S.: Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens. Mol. Biol. Cell., 2011, 22 (9).

Rüffer C., Gerke V.: The C-terminal cytoplasmic tail of claudins 1 and 5 but not its PDZ-binding motif is required for apical localization at epithelial and endothelial tight junctions. Eur. J. Cell Biol., 2004, 83 (4).

Angelow S., Ahlstrom R., Yu A.S.L.: Biology of cladins, American Journal of Physiology Renal Physiology, 2008, 295 (4).

Fromm M., Schulzke J.D.: Molecular structure and function of the tight junction. Ann. N.Y. Acad. Sci., 2009, 165.

Simon D.B., Lu Y., Choate K.A.: Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 1999, 285.

Haj-Rabia S., Baala L., Vabres P., Hamel-Teillac D., Jacquemin E., Fabre M., Lyonnet S., De Prost Y., Munnich A., Hadchouel M.: Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. Gastroenterology, 2004, 127.

Baker M., Reynolds L.E., Robinson S.D., Lees D.M., Parsons M., Elia G.: Stromal Claudin14-Heterozygosity, but Not Deletion, Increases Tumour Blood Leakage without Affecting Tumour Growth. PLoS ONE, 8 (5).

http://www.genecards.org,

http://schmieder.fmp-berlin.info/research/tight_junctions.htm

http://ghr.nlm.nih.gov/gene/CLDN14

https://www.ncbi.nlm.nih.gov/gene/23562




DOI: http://dx.doi.org/10.5281/zenodo.2560054

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