Recent studies have shown significantly increasing importance of new risk factors such as high levels of homocysteine and C-reactive protein, the presence of thrombophilia markers in the development of stroke. However, information of their relationship in acute defferent types of stroke and acute cardio-vasculares complications caused by stroke, is limited. The study showed that the impact of biomarkers on the stroke severity is age-dependent and hyperhomocysteinemia is play great importance role.

stroke, homocysteine, hyperhomocysteinemia

Donnan G. Stroke / G. ADonnan, M. Fisher, M. Macleod, S. MDavis // The Lancet. — 2008. — № 371. — P. 1612-1623.

Miniňo A.M. Deaths: Final data for 2008 / A.M. Miniňo, S.L. Murphy, J. Xu, K.D. Kochanek // National Vital Statistics Reports. — 2011. — № 8 (7). — P. 9-11.

Mishchenko T.S. Faktory riska i klinicheskiye osobennosti u bol'nykh s razlichnymi podtipami ishemicheskogo insul'ta / T.S. Mishchenko, N.V. Ovsyannikova, V.V. Lebedinets // Mezhdunarodnyy meditsinskiy zhurnal. — 2011. — № 3. — S.27-32. (in Russian)

Dzyak L.A. Insul't u patsiyentov molodogo vozrasta / L.A. Dzyak, Ye.S. Tsurkalenko // Prakticheskaya angionevrologiya. — 2010. — № 2. — S. 9-14. (in Russian)

Yevtushenko S.K., Lisovskiy Ye.V., Yevtushenko O.S. Displaziya soyedinitel'noy tkani v nevrologii i pediatrii (klinika, diagnostika, lecheniye): Rukovodstvo dlya vrachey. — Donetsk, 2009. — 372 s. (in Russian)

Mishchenko T.S. Faktory riska i klinicheskiye osobennosti u bol'nykh s razlichnymi podtipami ishemicheskogo insul'ta / T.S. Mishchenko, N.V. Ovsyannikova, V.V. Lebedinets // Mezhdunarodnyy meditsinskiy zhurnal. — 2011. — № 3. — S. 27-32. (in Russian)

Trabetti E. Homocysteine, MTHFR gene polymorphisms, and cardio–cerebrovascular risk / E. Trabetti // J. Appl. Genet. – 2008. – Vol. 49. – P. 267-282.

Williams K.T. Homocysteine metabolism and its relation to health and disease / K.T. Williams, K.L. Schalinske // Biofactors. – 2010. – № 36. – Р. 19-24.

Evtushenko S.K. Hormonal contraceptives as a risk factor for ischemic stroke in young women / SK. Evtushenko, M.F. Ivanova, S.V. Raids, I.S. Yevtushenko, I.Yu. Galayeva // International Neurological Journal. - 2008. - № 3 (18). - S. 72-76. (in Russian)

Zozulya I.S. Hyperhomocysteinemia and other metabolic predictors of the development and course of ischemic stroke / Zozulya I.S., Shevchuk V.I., Bezsmertna G.V. - K .: National Medical Academy of Postgraduate Education named after PL Shupika - 2011 - C.34¬36, 124-125. (in Ukrainian)

Zozulya I.S. Hyperhomocysteinemia and other metabolic predictors of the development and course of ischemic stroke / Zozulya I.S., Shevchuk V.I., Bezsmertna G.V. - K .: National Medical Academy of Postgraduate Education named after PL Shupika, 2011. - C.34-36, 124-25. (in Ukrainian)

Goldstein L.B., Bushnell C.D., Adams R.J., Appel L.J., Braun L.T., Chaturvedi S., Creager M.A., Culebras A., Eckel R.H., Hart R.G., Hinchey J.A., Howard V.J., Jauch E.C., Levine S.R., Meschia J.F., Moore W.S., Nixon J.V., Pearson T.A. Guidelines for the primary prevention of stroke. A guideline forbhealthcare professionals from the American Heart Association/American Stroke Association // Stroke. — 2010 Dec 6.

Zhang F., Slungaarg A., Vercellotti G.M., Iadecola C. Superoxide-dependent cerebrovascular effects of homocysteine // Am. J. Physiol. — 1998. — 274. — 1704-11.

Homocysteine Impairs the Nitric Oxide Synthase Pathway / Markus C., Stuhlinger P.S., Tsao Jeng-Horng Her., M. Kimoto et al. // Circulation. — 2001. — № 104. — P. 2569-2575.

Lonn E. Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease / E. Lonn, S. Yusuf, M.J. Arnold et al. // The New England Journal of Medicine. — 2006. — № 354(15). — P. 1567¬1577.

Lentz S.R., Haynes W.G. Homocysteine: Is it a clinically important cardiovascular risk factor // Clev. Clin. J. Med. — 2004. — V. 71. — Р. 729-734.

Filimonov D.A. Gipergomotsisteinemiya kak prokoagulyantnyy faktor riska u patsiyentov s aterotromboticheskim ishemicheskim insul'tom i vozmozhnosti lechebnoy korrektsii // Neyronauki: teoreticheskiye i klinicheskiye aspekty. — 2012. — № 8(2). — S. 204-208. (in Russian)

Clarke J.T.R. A Clinical Guide to Inherited Metabolic Diseases (3rd ed.). — Cambridge: Cambridge University Press, 2005. — P. 358.

Elsayed Z. Soliman. Homocysteine, vitamins, and vascular disease prevention / Elsayed Z. Soliman // American Journal of Clinical Nutrition. — 2007. — № 86. — P. 1563-1568.

Havva Sahin Kavakli. Homocysteine Levels in Acute Ischemic Stroke Patients / Havva Sahin Kavakli, Neriman Defne Altintas, Tanriverdi Fatih // Journal of Academic Emergency Medicine. — 2010.

Helga Refsum. The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease.

Homocysteine Studies Collaboration. Homocysteine and risk of ischemicheart disease and stroke: a meta-analysis // JAMA. — 2002. — 288. — 2015-2022.

Wang X., Qin X., Demirtas H., Li J., Mao G., Huo Y., Sun N., Liu L., Xu X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis // Lancet. — 2007. — 369. — 1876-1882.

Recep Aygul. Plasma and cerebrospinal fluid homocysteine, nitric oxide and malondialdehyde levels in acute ischemic stroke: possible role of free radicals in the development of brain injury / Recep Aygul, Dilcan Kotan, Abdulkadir Yildirim, Hizir Ulvi, Fatih Akcay // Eur. J. Gen. Med. — 2008. — 5 (2). — 57-63.

Howard V.J., Sides E.G., Newman G.C., Cohen S.N., Howard G., Malinow M.R., Toole J.F. Changes in plasma homocysteine in the acute phase after stroke // Stroke. — 2002. — 33. — 473-78.

Kilmer S. McCully. The Biomedical Significance of Homocysteine / Kilmer S. McCully // Journal of Scientific Exploration. — 2001. — Vol. 15, № 1. — Р. 5-20.