Acute hypersensitivity pneumonitis associated with mushroom worker’s lung – a case report

Marcelina Makuch, Janusz Milanowski, Michał Palonka, Marcin Makuch, Marek Michnar


Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis is a non-IgE mediated allergic reaction to inhalation of an allergen. There are more than 200 allergens known to cause this condition, but the list of antigens responsible for the development of HP is constantly expanded. Dangerous agents are usually inhaled at the workplace, so we may distinguish the following patients at risk of HP: farmers, pigeon breeders, mushroom workers, cheese employees or even malt workers. Mushroom worker's lung (MWL) has been described in workers exposed to mushroom spores or to inhaled antigens from compost (mostly thermophilic actinomycetes).


acute hypersensitivity pneumonitis; mushroom worker's lung; thermophilic actinomycetes

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Selman M, Pardo A, King TE Jr. Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med 2012; 186:314. 2. Selman M. Hypersensitivity pneumonitis. In: Interstitial Lung Disease, 5th ed, Schwarz MI, King TE Jr (Eds), People's Medical Publishing House - USA, Shelton, CT 2011. p.597.

Andrews K, Abdelsamed H, Yi AK, et al. TLR2 regulates neutrophil recruitment and cytokine production with minor contributions from TLR9 during hypersensitivity pneumonitis. PLoS One 2013; 8:e73143.

Agostini C, Trentin L, Facco M, Semenzato G. New aspects of hypersensitivity pneumonitis. Curr Opin Pulm Med 2004; 10:378.

Bourke SJ, Dalphin JC, Boyd G, et al. Hypersensitivity pneumonitis: current concepts. Eur Respir J Suppl 2001; 32:81s.

Spagnolo P, Rossi G, Cavazza A, et al. Hypersensitivity Pneumonitis: A Comprehensive Review. J Investig Allergol Clin Immunol 2015; 25:237.

Villar A, Muñoz X, Sanchez-Vidaurre S, et al. Bronchial inflammation in hypersensitivity pneumonitis after antigen-specific inhalation challenge. Respirology 2014; 19:891.

Cormier Y, Lacasse Y. Keys to the diagnosis of hypersensitivity pneumonitis: The role of serum precipitins, lung biopsy, and high-resolution computed tomography. Clin Pulm Med 19963(2):72-77. []

Schuyler M, Cormier Y. The diagnosis of hypersensitivity pneumonitis. Chest 1997;111(3):534-536.

Bringhurst LS, Byrne RN, Gershon-Cohen J. Respiratory disease of mushroom workers. JAMA 1959; 171; 101-104.

Sakula A. Mushroom-worker's lung. Br Med J. 1967 Sep 16;3(5567):708–710.

Wiatr E, Rowińska-Zakrzewska E, Pirożyński M. Choroby śródmiąższowe płuc. α-medica press 2012; 133

Jackson E, Welch K. M. A. Mushroom worker’s lung. Thorax 1970; 25(1): 25–30.

Steinman HA. f212 Mushroom (Champignon). miscellaneous/mushroom-champignon (accessed 7 January 2019).

Selman M, Vargas MH. Airway involvement in hypersensitivity pneumonitis. Curr Opin Pulm Med 1998;4:9-15.

Richerson HB, Bernstein IL, Fink JN, et al. Guidelines for the clinical evaluation of hypersensitivity pneumonitis. Report of the Subcommittee on Hypersensitivity Pneumonitis. J Allergy Clin Immunol 1989; 84:839.

Hansell DM, Moskovic E. High-resolution computed tomography in extrinsic allergic alveolitis. Clin Radiol 1991;43:8-12.

Adler BD, Padley SP, Muller NL, Remy-Jardin M, Remy J. Chronic hypersensitivity pneumonitis: High-resolution CT and radiographic features in 16 patients. Radiology 1992;185:91-9

Cormier Y, Brown M, Worthy S, Racine G, Muller NL. High-resolution computed tomographic characteristics in acute farmer’s lung and in its follow-up. Eur Respir J 2000;16:56-60.

D'Ippolito R, Chetta A, Foresi A, et al. Induced sputum and bronchoalveolar lavage from patients with hypersensitivity pneumonitis. Respir Med 2004; 98:977.

Ohshimo S, Bonella F, Cui A, et al. Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009; 179:1043.

Caillaud DM, Vergnon JM, Madroszyk A, et al. Bronchoalveolar lavage in hypersensitivity pneumonitis: a series of 139 patients. Inflamm Allergy Drug Targets 2012; 11:15.

Takemura T, Akashi T, Kamiya H, et al. Pathological differentiation of chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis/usual interstitial pneumonia. Histopathology 2012; 61:1026.

Myers JL. Hypersensitivity pneumonia: the role of lung biopsy in diagnosis and management. Mod Pathol 2012; 25 Suppl 1:S58.

Mönkäre S. Influence of corticosteroid treatment on the course of farmer's lung. Eur J Respir Dis 1983; 64:283.

Kokkarinen JI, Tukiainen HO, Terho EO. Effect of corticosteroid treatment on the recovery of pulmonary function in farmer's lung. Am Rev Respir Dis 1992; 145:3.



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