The role of the prooxidative-antioxidative system in dentistry

Agnieszka Markowska-Dyner


During physiological processes, a number of chemical reactions take place in all cells including oxidation and reduction.Those reactions can result in the production of free radicals, ie., atoms or atom groupsthat have one or more unpaired electrons and thereforeextremely high chemical reactivity. Numerous free radicals are formed through natural processes; the levels of free radicals in the cell depends, among others, on physical activity, environmental factors (eg., ionizing radiation from natural or artificial sources, toxins such as exhaust fumes) and lifestyle-relatedstress. Generation of free radicals is associated with oxidative and nitrosative stress. Oxidative stress is defined as a disturbance in cell homeostasis leading to an increase in reactive oxygen species (ROS). It is also a disturbance in the balance between oxidation processes and antioxidant defenses.


prooxidative-antioxidative system in dentistry

Full Text:



Brock G.R., Butterworth C.J., Matthews J.B.,Chapple I. L. Local and systemic total antioxidant capacity in periodontitis and health. J.Clin. Periodontol. 2004, 31, 515–521

Czeczot H., Skrzycki M.: Enzymatic and non-enzymatic antioxidants of saliva - a literature review. Czas. Stomatol. 2003, 56.

Konopka T., Gmyrek-Marciniak A., Kozłowski Z., Kaczmarek U., Wnukiewicz J.: Antioxidant Capacity of Saliva in Patients with Periodontitis and Squamous Carcinoma of the Mouth Floor. Dent. Med. Probl. 2006, 43, 354–362

Bartosz G., : Druga twarz tlenu. Wolne rodniki w przyrodzie, Wydawnictwo PWN 2008

Henrotin Y.E., Bruckner P., Pujol J.P.: The role of reactive oxygen species in homeostasis and degeneration of cartilage. Osteoarthritis Cartilage, 2003, 11, 747–755

Inoue M., Sato E.F., Nishikawa M., Park A.M., Kira Y., Imada I., Utsumi K.: Mitochondrial generation of reactive oxygen species and its role in aerobic life. Curr. Med. Chem., 2003,10, 2495–2505

Ohashi M., Iwase M., Nagumo M.: Elevated production of salivary nitric oxide in oral mucosal diseases. J. Oral Pathol. Med. 1999, 28, 355–359

Kensler. Trush M. A. Role of oxygen radicals in tumor promotion. Enwiron. Mutagen. 1984, 6 (4), 593-616

Guemouri L, Artur Y, Herbeth B, Jeandel C, Cuny G, Siest G. Biological variability of superoxide dismutase, glutathione, peroxidase and catalase in blood.

Clin. Chem. 1991, 37 (1) 1932-1937

Bahar G., Feinmesser R., Shpitzer T., Popovtzer A., Nagle R.M.: Salivary analysis in oral cancer patients. DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer 2007, 109, 54 -59

Czygier M., Kamocki, Ławicki, Szmitkowski Poziom mieloperoksydazy ( MPO ) oraz całkowity status antyoksydacyjny TAS w osoczu chorych na raka żołądka leczonych operacyjnie. PrzeglądLekarski, 2010, 67.7. 443-445

Antoneeva I.I., Genig T. P.: Neutrophilic granulocytes in of the ovarian cancer progression Klin.Lab.Diagn. 2007, Aug(8), 43-45

Vuillaume M. Reduced oxygen species, mutation, induction and cancer initiation. Mutation Res. 1987, 186 (1), 43- 72.

Meucci E., Littarru C., Deli G. et al.: Antioxidant status and dialysis: plasma and saliva antioxidant activity in patientswith fluctuating uratelevels.Free Rad. Res., 1998, 29, 367-76 Nie ma przypisanegonumeruliteraturowego

Fitak E, Grzegorczyk-Jaźwińska A.;-:Wolne rodniki i ich aktywność w układach biologicznych.Nowa Stomatologia 1999, 3, 27-30

Król K, Konopka T: Reaktywne pochodne tlenu i mechanizmy antyoksydacyjne w patogenezie zapaleń przyzębia. DentMedProb 2003, 40 (1), 121-128

Sobaniec H: Rola wolnych rodników w fizjologii i patologii człowieka. CzasopismoStomatologiczne 1997, t 50, nr 10, s. 698-703

Salzman R,PacalL,Tomandl J.; Elevated malondialdehyde correlates with the extent of

primary tumor and predicts poor prognosis of oropharyngeal cancer. Anticancer Res. 2009 Oct;29(10):4227-31.

Beevi S, S. ,Rasheed A.M. ,Geetha A.: Evaluation of oxidative stress and nitric oxide levels in patient with oral cavity cancer. Jpn J ClinOncol 2004, 34(7) 379-385

Hensley K, Robinson K A, Gobbite S, Salsman S, Floryd R A. Reactive oxygen species, cell signaling and cell injury. Free Radic. Biol. Med. 2000, 28, 1456- 1462

Sies H.: Oxidative stress: oxidants and antioxidants. Exp. Physiol 1997, 82, 291- 295

Fridovich J.: Superoxide radical and superoxide dismutases. Ann. Rev. Biochem 1995, 64, 97- 112

Drobek Słowik M.: Potencjalny udział stresu oksydacyjnego w patogenezie zwyrodnienia plamki związanego z wiekiem (AMD), Postępy Higieny i Medycyny Doświadczalnej 2007, 6.

Koksoy C., et al. Trace elements and superoxide dismutase in benign and malignant breast diseases.; Breast Cancer Res Treat. 1997, 45(1), 1-6

Oberley L.W.,Oberley T.D., Role of antioxidant enzymes in cell ; J.Theor.Biol., 1984, 106, 403-422.

Oberley L. W.Buttner G. R. Role of superoxide dismutase in cancer: a review. Cancer Res. 1979, 39, 1141- 1149

Church S. L. et al;. Increased manganese superoxide dismutase expression suppresses the malignant pheonotype of human melanoma cells. Proc. Natl. Acad. Sci. USA 1993, 90 (7), 3113-3117

Namysłowski G. Sobczuk A. Aktywność enzymatyczna układu antyoksydacyjnego w zależności od stopnia zaawansowania klinicznego raka krtani, 2000, 62.

Barańczyk – Kuźna A. Bariera antyoksydacyjna u chorych na raka żołądka- badania wstępne. K i Z. Biochemii Akademii Medycznej w Warszawie.

Malafa M., et al. MnSOD expression is increased in metastatic gastric cancer. Surg. Res. 2000, 88(2), 130-134.

Janssen A.M.L., et al. Superoxide dismutases in human colorectal cancer sequence.: J. Cancer Res. Clin. Oncol. 1999, 125, 327-335.

Taniguchi N. Clinical significances of superoxide dismutases: changes in aging, diabetes, ischemia, and cancer. Adv. Clin. Chem. 1992, 29, 1-59.

Guner G., et al. Evaluation of some antioxidant enzymes in lung carcinoma tissue.: Cancer Lett. 1996, 103(2), 233-239.

Battino M, Ferreiro M S, Gallardo I, NewmanH N, Bullon P: The antioxidant capacity of saliva.JClinPeriodontol 2002, 29: 189-194.

Czeczot H, Skrzycki M: Enzymatyczne i nieenzymatyczne antyoksydanty śliny - na podstawie piśmiennictwa. CzasStomatol 2003, LVI, 12, 817-823

Edgar W M: Saliva: its secretion, composition and function . Br Dent J 1992, 172, 305-

Gokul S(1),PatilVS,JailkhaniR,HallikeriK,Kattappagari KK ; Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients. Oral Disc. 2010; 16, 29-33

Gurudath S Ganapathy K, Estimation of superoxide SOD and GPx in oral submucous fibrosis, oral leukoplakia and oral cancer - a comparative study.; Asian Pac. J Cancer Prev. 2012;13(9) 4409-12

Huo W., Li ZM., Pan XY., Bao YM., An LJ.: Antioxidant enzyme levels in pathogenesis of oral squamous cell carcinoma (OSCC).Drug Res (Stuttg). 2014 Nov;64(11):629-32

Hodges R.E:Vitamin C and cancer. Nutr. Rev. 1982, 40, 289-92

Hornig D, Vuilleumier J.P; Hartman D: Absorption of large, single oral intakes of ascorbic acid. Int. J.nutr. Res. 1980, 50(3) 309-14

Sporn M. B., Roberts A. B.: Role of retinoids in differentiation and carcinogenesis. Cancer Res. 1983, 43, 30-39.

Wald N.: Low serum vitamin A and subsequent risk of cancer: preliminary results of prospective study. Lancet 1980, 813-815.

Malmezat T., Breuille D., Capitan P., Mirand P.P., Obled Ch.: Glutathione turnover is increased during the acute phase of sepsis in rats. J. Nutr. 2000, 130: 1239–1246.

Korkmaz A., Reiter R.J., Topal T., Manchester L.C., Oter S., TanD.X.: Melatonin: An established antioxidant worthy of use in clinicaltrials. Mol. Med., 2009, 15, 43-50

McCord, J. M. Fridovich,: Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

J. Biol. Chem. 1969, 244, 6049

Babior BM. et al. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. The production by leukocyctes of superoxide, a potential bactericidal agent J. Clin, Inwest. 1973 52, 741-4

D. N. Granger et al.: Superoxide radicals in feline intestinal ischemia; Gastroenterology 1981,81(1), 22-29

Aurer A.,Aurer-Kozelj J.,Stavljenic-Rukavina A., Kalenic S.,Ivic-Kardum M., Haban V. Inflammatory mediators in saliva of patients with rapidly progressive peridontitis during war stress inducedincidence increase.Co 11.Antropol.1999,23,117-124

Sugano N., Yokoyama K., Oshikawa M., Kumagai K., Takane M., Tanaka H. et al.: Detection of Streptococcus anginosus and 8-hydoxydeoxyguanosine in saliva. : J. Oral Sci. 2003, 45, 181–184



  • There are currently no refbacks.

Copyright (c) 2018 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski