The role of intestinal dysbiozis in infringement of the function of the liver of rats after antibiotic therapy

A. V. Bocharov, O. A. Makarenko, L. I. Semik, T. V. Gladky, A. V. Maykova

Abstract


In experimental work on rats was shown that antibiotics with the most pronounced hepatotoxic effects contribute more to the development of dysbiosis of the colon and to an increase in serum urease activity. On the basis of the results obtained, an assumption was made of the hepatotoxic effect of urease on the pathogenic microbiota of the intestine.

Keywords


antibiotics, dysbiosis of intestinal, urease, liver

Full Text:

PDF

References


Bаbаk О.Ya. Liver medications: theory and practice. Lіky Ukrainy. 2008; (118): 96-101. (in Russian).

Levitskiy A. P., Dem’yanenko S. A., Tsiselskiy Yu. V. Antimicrobial liver function. Оdеssа, KP OGT, 2011: 141. (in Russian).

Harris PR, Mobley HL, Perez-Perez GI et al. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology 1996; 111: 419-25.

European convention for the protection of vertebrate animals used for experimental and other scientific purpose: Council of Europe, 18.03.1986, Strasbourg, 1986: 52.

Goryachkоvskiy А. М. Clinical chemistry in laboratory diagnosis - handbook. Оdеsа, Еkоlоgіya, 2005: 616. (in Russian).

Levitsky A. P., Denga O. V., Makarenko O. A. [et al.]. Biochemical markers of inflammation of oral cavity tissue: method guidelines. Оdеssа, KP OGT, 2010:16. (in Russian).

Levitskiy A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Enzymatic methods for determination of oral dysbiosis for screening pro- and prebiotics: method guidelines]. Кiev, GFC, 2007: 22. (in Russian).

Sernov L. N., Gatsura V. V. Elements of Experimental Pharmacology. Мoscow, Medicine, 2000: 117-119. (in Russian).

Tsyryuk О. І. Mechanisms of functioning of the secretory apparatus of the stomach under conditions of prolonged hyperhastrinemia. Abstract of dissertation for doctor of biology scienes. Kiev 2017:38. (in Ukrainian).

Skrypkina I.N., Маslova А.S. The role of disorders of intestinal microbiocenosis in the pathogenesis of diseases of internal organs. Lіky Ukrainy. 2009;6(132):65-71. (in Russian).

Ryabichenko E. V., Bondarenko V. M. The role of intestinal bacterial autoflora and its endotoxin in pathology of human. Zhurnal mikrobiologii, epidemiologii, immynologii. 2007;3:103-111. (in Russian).

Wang X., Quinn P. Endotoxins: structure, function and recognition, Seria: Subcellular Biochemistry. 2010;53:415.




DOI: http://dx.doi.org/10.5281/zenodo.1889338

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2018 © The Author (s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 2011: 5.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)