Lipopolisacharid disrupts the function of the liver in dysbiosis

O. A. Мakarenko, A. P. Levitsky, A. V. Bocharov

Abstract


The paper presents the results of a study of the effect of lincomycin and lipopolysaccharide on the degree of dysbiosis in the intestinal mucosa and indicators of the functional activity of the liver of laboratory rats.
It is established, that the introduction of lincomycin and lipopolysaccharide increases the degree of dysbiosis in the mucosa of the colon, increases the activity of alkaline phosphatase and elastase in the liver, and also increases the level of bilirubin, the activity of alkaline phosphatase and alanine aminotransferase in the blood serum of animals. Based on the data obtained, it is assumed that the cause of functional disorders of the liver is lipopolysaccharide, which produces opportunistic bacteria in dysbiosis.

Keywords


dysbiosis, antibiotic, lipopolysaccharide, functional parameters of the liver

Full Text:

PDF

References


Dеnisova М. F., Muzyka N. М. Features of formation of intestinal dysbiosensis in children with chronic viral hepatitis and methods of their correction. Sіmeyna mеditsina. 2006; 2: 56 57. (in Ukrainian).

Ivashkin V. T. Mechanism of immune tolerance and liver pathology. Rossiyskiy zhurnal gastroenterologii, hеpаtоlogii, cоlоprоktologii. 2009; 2: 8-13. (in Russian).

Pеtukhov V. А. Dysbiosis, endotoxic aggression, dysfunction of the liver and dysfunction of the endothelium in surgery. A modern view of the problem. Khirurg. 2006; 10: 13-18. (in Russian).

Levitskiy A. P., Dem’yanenko S. A., Tsiselskiy Yu. V. Antimicrobial liver function. Оdеssа, KP OGT, 2011: 141. (in Russian).

Levitsky A. P., Makarenko O. A., Maykova A.V. [et al.]. The lysozyme activity in liver and colon dysbiozis after experimental antibiotic therapy. Scientific Journal “ScienceRise: Biological Science”.2017; 5(8):7-11. (in Russian).

Gavrikova L. M., Segen I. T. Urease activity of oral fluid in patients with acute odontogenic infection of maxillofacial area. Stomatologiya. 1996; Special vol.: 40-50. (in Russian).

Levitskiy A. P. Lysozyme instead of antibiotics. Оdеssа, KP OGT, 2005:55-56. (in Russian).

Levitskiy A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Enzymatic methods for determination of oral dysbiosis for screening pro- and prebiotics: method guidelines]. Кiev, GFC, 2007: 22. (in Russian).

Levitskiy A. P., Stefanov A. V. Methods for determination of activity of elastase and its inhibitors. Кiev, GFC, 2002: 15. (in Russian).

Goryachkоvskiy А. М. Clinical chemistry in laboratory diagnosis - handbook. Оdеsа, Еkоlоgіya, 2005: 616. (in Russian).

Sernov L. N., Gatsura V. V. Elements of Experimental Pharmacology. Мoscow, Medicine, 2000: 117-119. (in Russian).

Savilov P. N., Dyachkova S. Ya., Kuzmina N. I. Lysozyme-enriching function of the liver after partial hepatectomy and hyperbaric oxygenation. Voprosyi biologicheskoy, meditsinskoy i farmatsevticheskoy himii. 2005;4:35-39. (in Russian).

Sоzinоv А. S. The possibility of participation of endotoxin of gram-negative bacteria in the pathogenesis of liver damage in viral hepatitis. Byuleten experimentalnoy biologii, immynologii, mikrobiologii. 2009; 133, 3: 327-330 (in Russian).

Quigley Е., Stanton C., Murphy Е. The gut microbiota and the liver. Pathophysiological and clinical implications. J. Hepatol. 2013; 58:1020-1027.




DOI: http://dx.doi.org/10.5281/zenodo.2334038

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author (s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)