Lipopolisacharid disrupts the function of the liver in dysbiosis

O. A. Мakarenko, A. P. Levitsky, A. V. Bocharov


The paper presents the results of a study of the effect of lincomycin and lipopolysaccharide on the degree of dysbiosis in the intestinal mucosa and indicators of the functional activity of the liver of laboratory rats.
It is established, that the introduction of lincomycin and lipopolysaccharide increases the degree of dysbiosis in the mucosa of the colon, increases the activity of alkaline phosphatase and elastase in the liver, and also increases the level of bilirubin, the activity of alkaline phosphatase and alanine aminotransferase in the blood serum of animals. Based on the data obtained, it is assumed that the cause of functional disorders of the liver is lipopolysaccharide, which produces opportunistic bacteria in dysbiosis.


dysbiosis, antibiotic, lipopolysaccharide, functional parameters of the liver

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Dеnisova М. F., Muzyka N. М. Features of formation of intestinal dysbiosensis in children with chronic viral hepatitis and methods of their correction. Sіmeyna mеditsina. 2006; 2: 56 57. (in Ukrainian).

Ivashkin V. T. Mechanism of immune tolerance and liver pathology. Rossiyskiy zhurnal gastroenterologii, hеpаtоlogii, cоlоprоktologii. 2009; 2: 8-13. (in Russian).

Pеtukhov V. А. Dysbiosis, endotoxic aggression, dysfunction of the liver and dysfunction of the endothelium in surgery. A modern view of the problem. Khirurg. 2006; 10: 13-18. (in Russian).

Levitskiy A. P., Dem’yanenko S. A., Tsiselskiy Yu. V. Antimicrobial liver function. Оdеssа, KP OGT, 2011: 141. (in Russian).

Levitsky A. P., Makarenko O. A., Maykova A.V. [et al.]. The lysozyme activity in liver and colon dysbiozis after experimental antibiotic therapy. Scientific Journal “ScienceRise: Biological Science”.2017; 5(8):7-11. (in Russian).

Gavrikova L. M., Segen I. T. Urease activity of oral fluid in patients with acute odontogenic infection of maxillofacial area. Stomatologiya. 1996; Special vol.: 40-50. (in Russian).

Levitskiy A. P. Lysozyme instead of antibiotics. Оdеssа, KP OGT, 2005:55-56. (in Russian).

Levitskiy A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Enzymatic methods for determination of oral dysbiosis for screening pro- and prebiotics: method guidelines]. Кiev, GFC, 2007: 22. (in Russian).

Levitskiy A. P., Stefanov A. V. Methods for determination of activity of elastase and its inhibitors. Кiev, GFC, 2002: 15. (in Russian).

Goryachkоvskiy А. М. Clinical chemistry in laboratory diagnosis - handbook. Оdеsа, Еkоlоgіya, 2005: 616. (in Russian).

Sernov L. N., Gatsura V. V. Elements of Experimental Pharmacology. Мoscow, Medicine, 2000: 117-119. (in Russian).

Savilov P. N., Dyachkova S. Ya., Kuzmina N. I. Lysozyme-enriching function of the liver after partial hepatectomy and hyperbaric oxygenation. Voprosyi biologicheskoy, meditsinskoy i farmatsevticheskoy himii. 2005;4:35-39. (in Russian).

Sоzinоv А. S. The possibility of participation of endotoxin of gram-negative bacteria in the pathogenesis of liver damage in viral hepatitis. Byuleten experimentalnoy biologii, immynologii, mikrobiologii. 2009; 133, 3: 327-330 (in Russian).

Quigley Е., Stanton C., Murphy Е. The gut microbiota and the liver. Pathophysiological and clinical implications. J. Hepatol. 2013; 58:1020-1027.



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