Cyanide poisoning from an alternative medicine treatment with apricot kernels in a 80-year-old female.
Abstract
Aim: The aim of the study is to depict the risk associated with apricot kernels ingestion on the base of the case report.
Methods: The analysis of the patient’s medical history and the review of available literature.
Results: 80- year- old female with the medical history of papillary thyroid cancer was admitted to the toxicology department due to accidental cyanide poisoning. The patient consumed extract consisted of milled apricot kernels, then suffered from dyspnea, vertigo and vomiting. After that, she lost consciousness. Lactic acidosis, highly specific for cyanide intoxication, was diagnosed during hospitalization. The patient was treated with fluid and steroid therapy, sodium bicarbonate and supplemental oxygen. On the 3rd day of stay, the patient was discharged with recommendation of control in toxicological clinic.
Conclusions: Initial symptoms of cyanide poisoning are not specific, therefore it is worth taking this poisoning into account in differential diagnosis, especially in oncological patients or in children.
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World Health Organization., National policy on traditional medicine and regulation of herbal medicines : report of a WHO global survey. World Health Organization, 2005. http://apps.who.int/medicinedocs/en/d/Js7916e/. Accessed November 24, 2018
Jatau A. I., Aung M. M. T., Kamauzaman T. H. T., Chedi B. A. Z., Sha’aban A., and Rahman A. F. A., ‘Use and toxicity of complementary and alternative medicines among patients visiting emergency department: Systematic review.’, J. Intercult. Ethnopharmacol., vol. 5, no. 2, pp. 191–7, 2016. doi:10.5455/jice.20160223105521
Frass M., Strassl R. P., Friehs H., Müllner M., Kundi M., and. Kaye A. D, ‘Use and acceptance of complementary and alternative medicine among the general population and medical personnel: a systematic review.’, Ochsner J., vol. 12, no. 1, pp. 45–56, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22438782. Accessed November 24, 2018.
Kemppainen L. M., Kemppainen T. T.,. Reippainen J. A, Salmenniemi S. T., and Vuolanto P. H., ‘Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants.’, Scand. J. Public Health, vol. 46, no. 4, pp. 448–455, Jun. 2018. doi:10.1177/1403494817733869
Olchowska-Kotala A.and Barański J., ‘Polish physicians’ attitudes to complementary and alternative medicine’, Complement. Ther. Med., vol. 27, pp. 51–57, Aug. 2016. doi:10.1016/J.CTIM.2016.05.004
Afifi F. U., Wazaify M., Jabr M., and Treish E., ‘The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan’, Complement. Ther. Clin. Pract., vol. 16, no. 4, pp. 208–212, Nov. 2010. doi:10.1016/J.CTCP.2010.05.001
Vetter J., ‘Plant cyanogenic glycosides’, Toxicon, vol. 38, no. 1, pp. 11–36, Jan. 2000. doi:10.1016/S0041-0101(99)00128-2
Akyildiz B. N., Kurtoğlu S., Kondolot M., and. Tunç A, ‘Cyanide poisoning caused by ingestion of apricot seeds’, Ann. Trop. Paediatr., vol. 30, no. 1, pp. 39–43, Mar. 2010. doi:10.1179/146532810X12637745451951
Borron S. W.and Baud F. J., ‘Antidotes for acute cyanide poisoning.’, Curr. Pharm. Biotechnol., vol. 13, no. 10, pp. 1940–8, Aug. 2012. http://www.ncbi.nlm.nih.gov/pubmed/22352728. Accessed November 19, 2018.
Hamel J., ‘A Review of Acute Cyanide Poisoning With a Treatment Update’, Crit. Care Nurse, vol. 31, no. 1, pp. 72–82, Feb. 2011. doi:10.4037/ccn2011799
Graham J.and Traylor J., Cyanide Toxicity. StatPearls Publishing, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29939573. Accessed November 24, 2018.
Dang T., Nguyen C., and Tran P. N, ‘Physician Beware: Severe Cyanide Toxicity from Amygdalin Tablets Ingestion.’, Case Rep. Emerg. Med., vol. 2017, p. 4289527, 2017. doi:10.1155/2017/4289527
Bolarinwa I. F.,. Orfila C, and Morgan M. R. A., ‘Amygdalin content of seeds, kernels and food products commercially-available in the UK’, Food Chem., vol. 152, pp. 133–139, Jun. 2014. doi:10.1016/j.foodchem.2013.11.002
Suchard J. R., Wallace K. L., and. Gerkin R. D, ‘Acute Cyanide Toxicity Caused by Apricot Kernel Ingestion’, Ann. Emerg. Med., vol. 32, no. 6, pp. 742–744, Dec. 1998. doi:10.1016/S0196-0644(98)70077-0
Jaswal V., Palanivelu J., and R. C, ‘Effects of the Gut microbiota on Amygdalin and its use as an anti-cancer therapy: Substantial review on the key components involved in altering dose efficacy and toxicity.’, Biochem. Biophys. reports, vol. 14, pp. 125–132, Jul. 2018. doi:10.1016/j.bbrep.2018.04.008
PDQ Integrative, Alternative, and Complementary Therapies Editorial Board A and CTEB., Laetrile/Amygdalin (PDQ®): Health Professional Version. National Cancer Institute (US), 2002. http://www.ncbi.nlm.nih.gov/pubmed/26389425. Accessed November 25, 2018.
Bromley J., B. G. Hughes, D. C. Leong, and N. A. Buckley, ‘Life-Threatening Interaction Between Complementary Medicines: Cyanide Toxicity Following Ingestion of Amygdalin and Vitamin C’, Ann. Pharmacother., vol. 39, no. 9, pp. 1566–1569, Sep. 2005. doi:10.1345/aph.1E634
Brien B. O, Quigg C., and Leong T., ‘Severe cyanide toxicity from “vitamin supplements”.’, Eur. J. Emerg. Med., vol. 12, no. 5, pp. 257–8, Oct. 2005. http://www.ncbi.nlm.nih.gov/pubmed/16175068. Accessed November 19, 2018.
Sauer H., Wollny C., Oster I., Tutdibi E., Gortner L., Gottschling S. et al , ‘Severe cyanide poisoning from an alternative medicine treatment with amygdalin and apricot kernels in a 4-year-old child’, Wiener Medizinische Wochenschrift, vol. 165, no. 9–10, pp. 185–188, May 2015. doi:10.1007/s10354-014-0340-7
Chereau N., Trésallet C., Noullet S., Godiris-Petit G., Tissier F., Leenhardt L. et al , ‘Prognosis of papillary thyroid carcinoma in elderly patients after thyroid resection: A retrospective cohort analysis.’, Medicine (Baltimore)., vol. 95, no. 47, p. e5450, Nov. 2016. doi:10.1097/MD.0000000000005450
Parker-Cote J. L., Rizer J.,. Vakkalanka J. P,. Rege S. V, and Holstege C. P., ‘Challenges in the diagnosis of acute cyanide poisoning’, Clin. Toxicol., vol. 56, no. 7, pp. 609–617, Jul. 2018. doi:10.1080/15563650.2018.1435886
Rajashekar T. and Okade R., ‘Irritant contact dermatitis to accidental exposure of cyanide.’, Indian J. Dermatol., vol. 58, no. 2, p. 162, Mar. 2013. doi:10.4103/0019-5154.108098
Baud FJ., Borron SW, Mégarbane B. , Trout H., Lapostolle F., Vicaut E. et al, ‘Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning’, Crit Care Med ,vol. 30, no. 9, pp 2044-50, 2002. doi:10.1097/01.CCM.0000026325.65944.7D
Beasley D. M. G.and Glass W. I., ‘Cyanide poisoning: pathophysiology and treatment recommendations’, Occup. Med. (Chic. Ill)., vol. 48, no. 7, pp. 427–431, 1998. doi:10.1093/occmed/48.7.427
Thompson J. P and Marrs T. C., ‘Hydroxocobalamin in cyanide poisoning’, Clin. Toxicol., vol. 50, no. 10, pp. 875–885, Dec. 2012. doi:10.3109/15563650.2012.742197
Marraffa J. M., Cohen V., and. Howland M. A, ‘Antidotes for toxicological emergencies: A practical review’, Am. J. Heal. Pharm., vol. 69, no. 3, pp. 199–212, Feb. 2012. doi:10.2146/ajhp110014
DOI: http://dx.doi.org/10.5281/zenodo.1844020
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