Matrix metalloproteinase-9 as an independent predictor of recurrence after catheter ablation of atrial fibrillation

A. V. Goryachiy, A. I. Gozhenko, E. M. Levchenko, V. V. Goriachyi, M. A. Kuznetsova, M. I. Arapu


Objectives: In this study, the serum level of matrix metalloproteinase-9 was studied as an independent predictor of recurrence after catheter ablation of a persistent form of atrial fibrillation.
Methods: The study included 46 patients with a persistent form of atrial fibrillation. In all patients, serum level of matrix metalloproteinase-9 was measured before the procedure of catheter radiofrequency ablation and its association with recurrence of arrhythmia at the end of the postoperative period was estimated.
Results: The follow-up period was 12.3+ for 6.4 months, in 16 (34.7%) patients there was a relapse of arrhythmia after the procedure of catheter radiofrequency ablation. The baseline level of matrix metalloproteinase-9 was higher in patients with relapsed arrhythmia (297.73 + 81.28 and 234.41 + 93.36 ng / ml, respectively, p=0.006). Multivariate analysis showed that parameters such as the level of matrix metalloproteinase-9, the history of atrial fibrillation and the diameter of the left atrium were independent predictors of arrhythmia recurrence.
Conclusion: The serum level of matrix metalloproteinase-9 is an independent predictor of arrhythmia recurrence after performing the procedure of catheter radiofrequency ablation in patients with persistent form of atrial fibrillation.


matrix metalloproteinase - 9, atrial fibrillation, catheter ablation

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