Hepatoprotective effect of antidysbiotic drugs in experimental metabolic syndrome

V. L. Vasiuk, A. P. Levitsky, E. M. Levchenko

Abstract


Modeling of experimental metabolic syndrome in Wistar male rats was accompanied by a sharp increase in neutrophils/lymphocytes ratio and decrease in the numbers of monocytes in the blood, as well as almost 5-fold increase in the urease activity, a 3-fold decrease in the activity of lysozyme, and significant increase in the levels of inflammatory markers (MDA and elastase) in the liver. A 13-fold increase was observed in the level of dysbiosis in the liver and a significant increase in the alkaline phosphatase activity. Using antidysbiotic drugs (Quertulin, Quertgial and lysozyme) normalized the state of liver.

Keywords


liver, metabolic syndrome, dysbiosis, immunodeficiency, antidisbiotic drugs

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DOI: http://dx.doi.org/10.5281/zenodo.1461734

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