β-Hydroxy-β-methylbutyrate (HMB) supplementation in prevention and treatment of elderly sarcopenia.

Dominika Cieślak, Michał Zarobkiewicz, Barbara Nieradko-Iwanicka


β-Hydroxy-β-methylbutyrate (HMB) is a leucine metabolite, naturally appearing in human body. Both leucine and HMB are believed to be potent protein synthesis enhancers in skeletal muscles. The current articles reviews and summarizes findings from original studies on the possible therapeutic role of HMB in elderly sarcopenia. HMB seems to be capable of not only preventing, but also reversing sarcopenia. Five main effects on skeletal muscles have been noted: 1) inhibition of protein breakdown and thus lower muscle degradation, 2) increased endoplasmic reticulum calcium release, 3) lower fat content in skeletal muscle, 4) increased oxygen metabolism, 5) stimulation of satellite cells and thus muscle regeneration. Therefore, HMB emerges as potentially useful agent in treating and preventing sarcopenia.


HMB; β-Hydroxy β-methylbutyrate supplementation; sarcopenia; older people; elderly

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Van Koevering M, Nissen S. Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo. Am J Physiol-Endocrinol Metab. 1992;262(1):E27–E31.

Holeček M. Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions: HMB supplementation and muscle. J Cachexia Sarcopenia Muscle [Internet]. 2017 May 10 [cited 2017 Aug 7]; Available from: http://doi.wiley.com/10.1002/jcsm.12208

Albert FJ, Morente-Sánchez J, Ortega FB, Castillo MJ, Gutiérrez Á. Usefulness of β-hydroxy-β-methylbutyrate (HMB) supplementation in different sports: an update and practical implications. Nutr Hosp. 2015 Jul 1;32(1):20–33.

Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, et al. International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB). J Int Soc Sports Nutr. 2013;10(1):6.

Hoffman JR, Gepner Y, Stout JR, Hoffman MW, Ben-Dov D, Funk S, et al. β-Hydroxy-β-methylbutyrate attenuates cytokine response during sustained military training. Nutr Res. 2016 Jun;36(6):553–63.

Jones MS, Rivera M, Puccinelli CL, Wang MY, Williams SJ, Barber AE. Targeted Amino Acid Supplementation in Diabetic Foot Wounds: Pilot Data and a Review of the Literature. Surg Infect. 2014 Dec;15(6):708–12.

Ogura Y, Yuki N, Sukegane A, Nishi T, Miyake Y, Sato H, et al. Treatment of pressure ulcers in patients with declining renal function using arginine, glutamine and ß-hydroxy-ß-methylbutyrate. J Wound Care. 2015 Oct;24(10):478–82.

Wong A, Chew A, Wang CM, Ong L, Zhang SH, Young S. The use of a specialised amino acid mixture for pressure ulcers: a placebo-controlled trial. J Wound Care. 2014;23(5): 259-269.

Imai T, Matsuura K, Asada Y, Sagai S, Katagiri K, Ishida E, et al. Effect of HMB/Arg/Gln on the Prevention of Radiation Dermatitis in Head and Neck Cancer Patients Treated with Concurrent Chemoradiotherapy. Jpn J Clin Oncol. 2014 May 1;44(5):422–7.

Yokota T, Hamauchi S, Yoshida Y, Yurikusa T, Suzuki M, Yamashita A, et al. A phase II study of HMB/Arg/Gln against oral mucositis induced by chemoradiotherapy for patients with head and neck cancer. Support Care Cancer 2018;26:3241–8.

Baxter JH, Carlos JL, Thurmond J, Rehani RN, Bultman J, Frost D. Dietary toxicity of calcium β-hydroxy-β-methyl butyrate (CaHMB). Food Chem Toxicol. 2005 Dec;43(12):1731–41.

Gerlinger-Romero F, Guimarães-Ferreira L, Giannocco G, Nunes MT. Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats. Growth Horm IGF Res 2011;21:57–62.

Yonamine CY, Teixeira SS, Campello RS, Gerlinger-Romero F, Rodrigues CF, Guimarães-Ferreira L, et al. Beta hydroxy beta methylbutyrate supplementation impairs peripheral insulin sensitivity in healthy sedentary Wistar rats. Acta Physiol. 2014 Sep;212(1):62–74.

Laviano A, Gori C, Rianda S. Sarcopenia and Nutrition. In: Advances in Food and Nutrition Research. Elsevier 2014, p. 101–36.

Doherty TJ. Invited Review: Aging and sarcopenia. J Appl Physiol. 2003 Oct;95(4):1717–27.

White TA, LeBrasseur NK. Myostatin and Sarcopenia: Opportunities and Challenges - A Mini-Review. Gerontology. 2014;60(4):289–93.

Yu S, Umapathysivam K, Visvanathan R. Sarcopenia in older people: Int J Evid Based Healthc. 2014 Dec;12(4):227–43.

Zembro A, Dziubek W, Skorupka E. Sarcopenia: Monitoring, Molecular Mechanisms, and Physical Intervention. 2014;63:9.

Dodds RM, Roberts HC, Cooper C, Sayer AA. The Epidemiology of Sarcopenia. J Clin Densitom. 2015 Oct;18(4):461–6.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412–23.

Muscaritoli M, Lucia S, Molfino A, Cederholm T, Rossi Fanelli F. Muscle atrophy in aging and chronic diseases: is it sarcopenia or cachexia? Intern Emerg Med. 2013 Oct;8(7):553–60.

Cheng S-J, Yang Y-R, Cheng F-Y, Chen I-H, Wang R-Y. The Changes of Muscle Strength and Functional Activities During Aging in Male and Female Populations. Int J Gerontol. 2014 Dec 1;8(4):197–202.

Janssen I, Heymsfield SB, Wang ZM, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol Bethesda Md 1985. 2000 Jul;89(1):81–8.

Gallagher D, Visser M, De Meersman RE, Sepúlveda D, Baumgartner RN, Pierson RN, et al. Appendicular skeletal muscle mass: effects of age, gender, and ethnicity. J Appl Physiol Bethesda Md 1985. 1997 Jul;83(1):229–39.

Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998 Apr 15;147(8):755–63.

Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002 Dec;57(12):M772-777.

Edström E, Altun M, Hägglund M, Ulfhake B. Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):663–74.

Argilés JM, Busquets S, Stemmler B, López-Soriano FJ. Cachexia and sarcopenia: mechanisms and potential targets for intervention. Curr Opin Pharmacol. 2015 Jun;22:100–6.

Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB, et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2002 May;57(5):M326-332.

Greenlund LJS, Nair KS. Sarcopenia--consequences, mechanisms, and potential therapies. Mech Ageing Dev. 2003 Mar;124(3):287–99.

Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, et al. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest. 1994 Jun;93(6):2379–86.

Wilson JM, Grant SC, Lee S-R, Masad IS, Park Y-M, Henning PC, et al. Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats. J Int Soc Sports Nutr. 2012 Apr 18;9(1):18.

Munroe M, Pincu Y, Merritt J, Cobert A, Brander R, Jensen T, et al. Impact of β-hydroxy β-methylbutyrate (HMB) on age-related functional deficits in mice. Exp Gerontol. 2017 Jan;87:57–66.

Ellis AC, Hunter GR, Goss AM, Gower BA. Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults. J Diet Suppl. 2018 Apr 19;1–13.

Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr. 2009 Feb;33(1):71–82.

Hankosky ER, Sherrill LK, Ruvola LA, Haake RM, Kim T, Hammerslag LR, et al. Effects of β-hydroxy-β-methyl butyrate on working memory and cognitive flexibility in an animal model of aging. Nutr Neurosci. 2017 Aug 9;20(7):379–87.

Kougias DG, Hankosky ER, Gulley JM, Juraska JM. Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats. Physiol Behav. 2017 Mar;170:93–9.

Kougias DG, Nolan SO, Koss WA, Kim T, Hankosky ER, Gulley JM, et al. Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats. Neurobiol Aging. 2016 Apr;40:78–85.

Flakoll P, Sharp R, Baier S, Levenhagen D, Carr C, Nissen S. Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition. 2004 May;20(5):445–51.

Berton L, Bano G, Carraro S, Veronese N, Pizzato S, Bolzetta F, et al. Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial. Atkin SL, editor. PLOS ONE. 2015 Nov 3;10(11):e0141757.

De Luis DA. Efecto En La Calidad De Vida Y En La Fuerza Muscular Por Dinamometría. Nutr Hosp. 2015 Jul 1;(1):202–207.

Vallejo J, Spence M, Cheng A-L, Brotto L, Edens NK, Garvey SM, et al. Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice. Csernoch L, editor. PLOS ONE. 2016 Mar 8;11(3):e0150066.

Russ DW, Acksel C, Boyd IM, Maynard J, McCorkle KW, Edens NK, et al. Dietary HMB and β-alanine co-supplementation does not improve in situ muscle function in sedentary, aged male rats. Appl Physiol Nutr Metab. 2015 Dec;40(12):1294–301.

Baptista IL, Silva WJ, Artioli GG, Guilherme JPLF, Leal ML, Aoki MS, et al. Leucine and HMB Differentially Modulate Proteasome System in Skeletal Muscle under Different Sarcopenic Conditions. Müller M, editor. PLoS ONE. 2013 Oct 4;8(10):e76752.

Moreland JD, Richardson JA, Goldsmith CH, Clase CM. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2004 Jul;52(7):1121–9.

Ayoung-Chee P, McIntyre L, Ebel BE, Mack CD, McCormick W, Maier RV. Long-term outcomes of ground-level falls in the elderly. J Trauma Acute Care Surg. 2014 Feb;76(2):498–503; discussion 503.

Targowski T. Sarcopaenia and rheumatoid arthritis. Reumatologia. 2017;55(2):84–7.

Deutz NEP, Pereira SL, Hays NP, Oliver JS, Edens NK, Evans CM, et al. Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr. 2013 Oct;32(5):704–12.

Standley RA, Distefano G, Pereira SL, Tian M, Kelly OJ, Coen PM, et al. Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. J Appl Physiol. 2017 Nov;123(5):1092–100.

Alway SE, Pereira SL, Edens NK, Hao Y, Bennett BT. β-Hydroxy-β-methylbutyrate (HMB) enhances the proliferation of satellite cells in fast muscles of aged rats during recovery from disuse atrophy. Exp Gerontol. 2013 Sep;48(9):973–84.

Hao Y, Jackson JR, Wang Y, Edens N, Pereira SL, Alway SE. β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. Am J Physiol-Regul Integr Comp Physiol. 2011 Sep;301(3):R701–15.

DOI: http://dx.doi.org/10.5281/zenodo.1415425


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