Methods of preparation of endometrium in patients with ovarian hyperstimulation syndrome before the transfer of vitrified / warmed embryos

O. M. Nosenko, D. R. Ayzyatulova

Abstract


The aim of the study was to develop a personified method of endometrium preparation for the transfer of vitrified / warmed embryos in women with the development of OHSS in IVF programs. 39 women with early OHSS after IVF, who were undergoing personalized correction of the morphofunctional state of the endometrium, and 39 patients with baseline OHSS II group undergoing standard therapy were examined and treated. Control group consisted of women without OHSS in the IVF cycle. Personalized correction of the morphofunctional state of the endometrium includes traditional hormonal replacement therapy and addition of adjuvants: preparation with extract of horse chestnut and thiamine hydrochloride, vitamin E, serratiopeptidase, myo-inositol, the product of proteolysis of the placenta of cattle, L-arginine aspartate. The application of the developed method for the preparation of endometrium for the transfer of vitrified / warmed embryos by the developed method contributed to the prolongation of pregnancy and the increase in the number of live births in 2,11 times (OR 3.17; 95% CI 1.20-8.39; p<0,02). The increase in absolute benefit (therapeutic benefit) of the proposed person-adjusted correction is 25.64% (95% CI 5.12-46.16%), an increase in relative benefit corresponds to a clinically significant effect of 111.10% (95% CI 9.40 – 307.40 %), the number of patients to be treated is 3.90 (95% CI 2.17-19.52). The developed method is effective for the preparation of endometrium for the transfer of vitrified / warmed embryos.

Keywords


in vitro fertilization, ovarian hyperstimulation syndrome, cycle segmentation, vitrified / warmed embryos, method of endometrium preparation, live births

Full Text:

PDF

References


Gromova OA, Goncharova EA, Torshin IU, Limanova OA, Kerimkulova NV. Prospects for the use of myo-inositol in the pre-gravity preparation of women with polycystic ovary and insulin resistance. Gynecology. 2014, 1: 58-65.

Potapov VA. Expediency of using arginine in therapy of luteal phase insufficiency in patients of reproductive age. Health of Ukraine. 2016; 2: 2-3.

Prihozhaya V. Escusane is an effective agent of plant origin for the treatment of venous disease. Acute and urgent conditions in the practice of a doctor. 2010; 3 (22). Published online 2010..

Chaika VK, Chaika AV, Nosenko OM. Receptivity of the endometrium in patients with infertility: monograph. Donetsk: Publishing house "Nouvelage", 2011. 243 p.

Cicek N, Eryilmaz OG, Sarikaya E, Gulerman C, Genc Ya. Vitamin E effect on controlled ovarian stimulation of unexplained infertile women. J Assist Reprod Genet. 2012 Apr; 29(4): 325–328. Published online 2012 Feb 1. doi: 10.1007/s10815-012-9714-1.

Denomme MM, Mann MR. Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies. Reproduction. 2012;144:393–409.

Domanski D, Zegrocka-Stendel O, Perzanowska A, Dutkiewicz M, Kowalewska M, Grabowska I, at al. Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications. PLoS One. 2016 Oct 11;11(10):e0164365. doi: 10.1371/journal.pone.0164365. eCollection 2016.

Eroglu A, Layman LC. Role of ART in imprinting disorders. Semin Reprod Med. 2012;30:92–104.

Farhi J, Ben-Haroush A, Andrawus N, Pinkas H, Sapir O, Fisch B, et al. High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation. Reprod Biomed Online. 2010;21:331–7.

Feuer SK, Camarano L, Rinaudo PF. ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies. Mol Hum Reprod. 2013;19:189–204.

Gupte V, Luthra U. Analytical techniques for serratiopeptidase: A review. J Pharm Anal. 2017 Aug; 7(4): 203–207. Published online 2017 Mar 22. doi: 10.1016/j.jpha.2017.03.005.

Imudia AN, Awonuga AO, Doyle JO, Kaimal AJ, Wright DL, Toth TL, et al. Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization. Fertil Steril. 2012;97:1374–9.

Imudia AN, Awonuga AO, Kaimal AJ, Wright DL, Styer AK, Toth TL. Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study. Fertil Steril. 2013;99:168–73.

Joo BS, Park SH, An BM, Kim KS, Moon SE, Moon HS. Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner. Fertil Steril. 2010;93:442–6.

Kajantie E, Hovi P. Is very preterm birth a risk factor for adult cardiometabolic disease? Semin Fetal Neonat Med. 2014;19:112–7.

Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril. 2012;98:368-377.

Roque M, Valle M, Kostolias A, Sampaio M, Geber S. Freeze-all cycle in reproductive medicine: current perspectives. JBRA Assist Reprod. 2017;21(1):49-53. doi: 10.5935/1518-0557.20170012.

Santos MA, Kuijk EW, Macklon NS. The impact of ovarian stimulation for IVF on the developing embryo. Reproduction. 2010;139:23–34.

Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96:344-348.

Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96:344–8.

Shapiro BS, Daneshmand ST, Restrepo H, Garner FC, Aguirre M, Hudson C. Matched-cohort comparison of single-embryo transfers in fresh and frozen-thawed embryo transfer cycles. Fertil Steril. 2013;99:389–92.

Shi Y, Wei D, Liang X, et al. Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial. Trials. 2014;15:154-154.

Simi G, Genazzani AR, Obino MER, Papini F, Pinelli S, Cela V, Artini P G/Inositol and In Vitro Fertilization with Embryo Transfer. Int J Endocrinol. 2017; 2017:5469409. Published online 2017 Feb 28. doi: 10.1155/2017/5469409. 201




DOI: http://dx.doi.org/10.5281/zenodo.1412472

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author (s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)