Assessment of significance and relation between risk factors of endometry cancer development in women with endometry hyperproliferative processes

V. G. Marichereda, N. A. Bykova, I. M. Shevchenko, A. G. Volyanska, N. M. Rozhkovskaya

Abstract


A retrospective analysis of 27 patient case histories with pathomorphologically confirmed diagnosis of endometrial cancer (EC) showed that the most common and statistically significant risk factors for the development of uterine body cancer are: age of a woman above 50 years, heredity and genetic predisposition, late menopause, polycystic ovary syndrome, thyroid gland diseases, diabetes mellitus, obesity, infertility of hormonal genesis, arterial hypertension, inflammatory diseases of female genital organs, early menarche. Hereditary non-polypous colorectal cancer (11.68%, 95% CI 0.59-227.89), and hepatobiliary system diseases (2.50%, 95% CI 0.71-8.72) according to our results are not statistically significant. In order to determine the risk of EC development, 3 rules based on the “AssociationRules method” have been developed. They are: the combination of late menopause and heredity can lead to the development of EC with a probability of 59.25% and accuracy of 88.88%, while the correlation coefficient is 88.88%; the presence of obesity or heredity in a woman above 50 years of age can lead to EC with a probability of 59.25% and accuracy of 80.00% with a correlation coefficient of 84.32%; the development of EC in women above 50 years of age with a late-onset menopause is possible with a probability of 62.96% and accuracy of 94.44%, while correlation coefficient is 89.59% in this case.

Keywords


risk factor, endometrial cancer

Full Text:

PDF

References


Тkachenko L. В., et al. Risk prognostic factors of endometrial hyperplasic processes development under menopause // Volgograd Scientific-Med. J. – 2013. - № 4. – P. 43 - 47.

Chernukha G. Е. Hyperplasia of endometrium: perspectives of the problem development // Obstetrics & Gynecology. – 2009. – № 4. – P. 11–15.

Sorosky J. I. Endometrial cancer / J. I. Sorosky // Obstet. Gynecol. – 2012. – Vol. 120. – Р. 383–397.

Коrnienko S. М. Endometrial hyperplasic processes in women at late reproductive and premenopausal period // Herald for Soc Hygiene and Health Care management in Ukraine. - 2017. - № 2 (72). - P. 39-47.

Nachajova M, Mersakova S, Sivakova J, Krivus S, Szepe P, Hatok J, Adamkov M. New molecular aspects of endometrial carcinoma //Neuro Endocrinol Lett.- 2015;36(7):638-43.

Ali A. T. Reproductive factors and the risk of endometrial cancer // Int J Gynecol Cancer. - 2014;24(3):384-93.

Uchikova E, Uchikov P, Parahuleva P. Obesity and endometrial сarcinogenesis // Akush Ginekol (Sofiia).- 2015;54(9):34-7.

Fedorenko Z. P., et al. Cancer in Ukraine, 2016–2017: morbidity, mortaliyu, indexes of oncological service // Bull Nat Cancer-register Ukr. — Kiev, 2018. — № 19. — 136 p.

Clinical and pathogenic features of endometrium hyperplastic processes in women of premenopausal period // Rus Med J “ Med Review”.- 2018.- N1 (I) .- P. 67-71.

Vlasov Р. С. Clinical meaning of methylate genes-suppressors of tumor growth at pathological prosesses of endometrium in reproductive age women: synopsis of a candidate thesis: specialty 14.01.01 «Obstetrics & Gynecology. – Moscow, 2011. – 21 p.

Vdovichenko Yu. P. Modern management of diagnostics and treatment of hyperplastic processes of endometrium (review of literature // Health of a Woman. – 2012. – № 9. – P. 45–53.

Unanian А. l. Prognosis of uterus body cancer in women with hyperplastic prosesses of endometriamin premenopausal period Прогнозирование рака тела матки у женщин с гиперпластическими процессами эндометрия в пременопаузальном возрасте // Obstetrics and Gynecology. Reproduction. - 2012. - №2 - P. 18-24.

Senechal C, Cottereau E, de Pauw A, Elan C, Dagousset I, Fourchotte V. Environmental and genetic risk factors for endometrial carcinoma.Bull Cancer.2015;102(3):256-69.

Sheshukova N.A., et al. Hyperplastic processes of endometrium: etiology, pathogeneses, clinics, diagnostics, treatment // Obst & Gynecol. – 2011. – № 4. – P. 16–21.

Shaw E, Farris M, McNeilJ, Friedenreich C. Obesity and Endometrial Cancer. Recent Results // Cancer Res. - 2016;208:107-136.

Zhang Y, Liu H, Yang S, Zhang J, Qian L, Chen X. Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int J Biol Markers. 2014;29(1):e21-9.

Ali AT. Risk factors for endometrial cancer.// Ceska Gynekol. 2013;78(5):448-59.

Ketabi Z, Mosgaard BJ, Gerdes AM, Ladelund S, Bernstein IT. Awareness of endometrial cancer risk and compliance with screening in hereditary nonpolyposis colorectal cancer. Obstet Gynecol. 2012;120(5):1005-12.

Gao J, Yang G, Wen W, Cai QY, Zheng W, Shu XO, Xiang YB. Impact of known risk factors on endometrial cancer burden in Chinese women. Eur J Cancer Prev. 2016;25(4):329-34.




DOI: http://dx.doi.org/10.5281/zenodo.1405097

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author (s) 2018

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)