Association between ACTN3 gene polymorphism and muscle strength in older adults

Sylwester Kłoska, Anna Marciniak, Marcin Woźniak, Radosław Perkowski, Marta Podhorecka, Dominika Gębka, Joanna Androsiuk-Perkowska, Sławomir  Kujawski, Marcin Kożuchowski, Henryk Kozłowski, Kornelia Kędziora-Kornatowska, Walery Zukow

Abstract


The decrease of muscle strength and general physical fitness is a big problem in the elderly group. It often prevents the proper functioning of a person, which makes him/her dependent on caretakers. It is believed that the some polymorphisms in ACTN3 geneare associated with better results in strength sports. If those polymorphisms affect muscle strength, they may also be related to the health condition of older people. Our study was conducted on a group of 60 people over 60 years of age. The relationship between overall fitness and muscular strength of elderly patients with ACTN R577X gene polymorphism was checked. The ACTN3 gene was tested by PCR-RFLP. Overall fitness was tested using the IPAQ questionnaire and fitness tests: Tinetti, DGI, Up&Go, SPPB, standing on one leg (both right and left). Based on the results of the survey, the MET and BMI coefficients were determined. It was found that the RX genotype is associated with better results achieved in the SPPB test. Genotype XX was associated with worse results in the right leg standing test (p<0.05). The R-allele of the ACTN3 gene wasassociated with better results obtained during the standing test on the right leg (p<0.05).Based on obtained results it was impossible to determine a clear impact of the ACTN3 gene on muscle strength and health of the older adults.

Keywords


sport geneticsł ACTN3ł older adultsł geriatric patient

Full Text:

PDF

References


K. Wieczorowska-Tobis, T. Kostka, Fizjoterapia w geriatrii, 2010.

R. Stupnicki, A.K. Gajewski, A.W. Fizycznego, Międzynarodowy Kwestionariusz Aktywności Fizycznej (IPAQ) – wersja polska, Wych. Fiz. I Sport. 2007; 51:47–54.

M.E. Tinetti, F.T. Williams, R. Mayewski, Fall risk index for elderly patients based on number of chronic disabilities., Am. J. Med. 1986; 80: 429–434.

S. Mathias, U. Nayak, B. Isaacs, Balance in elderly patients: the “get-up and go” test., Arch. Phys. Med. Rehabil. 1986 ;67:987–389.

J. McConvey, S.E. Bennett, Reliability of the dynamic gait index in individuals with multiple sclerosis, Arch. Phys. Med. Rehabil. 2005; 86:130–133.

J.M. Guralnik, E.M. Simonsick, L. Ferrucci, et al., A Short Physical Performance Battery Assessing Lower Extremity Function: Association With Self-Reported Disability and Prediction of Mortality and Nursing Home Admission, J. Gerontol. Med. Sci. 1994; 49:85–94.

T. Michikawa, Y. Nishiwaki, T. Takebayashi, et al., One-leg standing test for elderly populations, J. Orthop. Sci. 2009 ;14:675–685.

M. Mills, N. Yang, R. Weinberger, et al., Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy., Hum. Mol. Genet. 2001; 10:1335–46.

J.T. Seto, M. Lek, K.G.R. Quinlan, et al., Deficiency of ??-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling, Hum. Mol. Genet. 2011; 20:2914–2927.

A.-K. Niemi, K. Majamaa, Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes, Eur. J. Hum. Genet. 2005; 13:965–969.

N. Yang, D.G. MacArthur, J.P. Gulbin, et al., ACTN3 Genotype Is Associated with Human Elite Athletic Performance, Am. J. Hum. Genet. 2003; 73:627–631.

E.M. Pimenta, D.B. Coelho, I.R. Cruz, et al., The ACTN3 genotype in soccer players in response to acute eccentric training, Eur. J. Appl. Physiol. 2012; 112:1495–1503.

Statsoft.com, Statistica, (2017). http://statistica.io/.

R.A. Scott, R. Irving, L. Irwin, et al., ACTN3 and ACE genotypes in elite Jamaican and US sprinters, Med. Sci. Sports Exerc. 2010; 42:107–112.

F. Sessa, M. Chetta, A. Petito, et al., Gene polymorphisms and sport attitude in Italian athletes., Genet. Test. Mol. Biomarkers. 2011; 15:285–290.

I. Papadimitriou, C. Papadopoulos, A. Kouvatsi, et al., The ACTN3 gene in elite Greek track and field athletes., Int. J. Sport. Med. 2008; 29:352–355.

L. Chiu, Y. Wu, M. Tang, et al., ACTN3 genotype and swimming performance in Taiwan., Int. J. Sports Med. 2011; 32:468–480.

J. Ho Kim, E. Sun Jung, et al., Genetic associations of body composition, flexibility and injury risk with ACE, ACTN3 and COL5A1 polymorphisms in Korean ballerinas, J. Exerc. Nutr. Biochem. 2014; 18:205–214.

M.J. Delmonico, J.M. Zmuda, B.C. Taylor, et al., Association of the ACTN3 genotype and physical functioning with age in older adults, J. Gerontol. A. Biol. Sci. Med. Sci. 2008; 63:1227–1234.

A. Pereira, A.M. Costa, J.C. Leitão,et al., The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training, BMC Geriatr. 2013; 13:131.




DOI: http://dx.doi.org/10.5281/zenodo.1345234

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)