Malignant tumors are diseases occurring in any population in the world, characterized by a high mortality [1]. In the developed countries are the second cause of death after cardiovascular diseases. Among the risk factors for many cancers, distinguished tastes bad habits. A new trend in academic research on the effects of inadequate supply of selenium in the diet at risk of developing cancer, in particular carcinoma of the colon, lung or prostate cancer. The role of selenium, looking also for prevention against cardiovascular events. Cardiovascular disease 50 years of age are the biggest threat to his countrymen. CSO data show since 1992 that the participation of these diseases in the total number of deaths decreased from 52% to 45.6% in 2012. Selenium deficiency also affects, for example, the development of thyroid disease. Autoimmune thyroiditis, hypothyroidism or crop neutral. Deiodinase are selenoenzymes, which play an essential role in the metabolism of thyroid hormones. Deiodinase, type 1, 2 is involved in the process dejodacji thyroxine [T4] for the active company in the form of 3,3 ', 5-triiodothyronine [T3] [34]. Selenium is a trace element was discovered in 1817 by Swedish chemist Berzelius. Until 1957 was considered, for the root of the toxic effects. Selenium is a trace element belonging to the micro [17,18,19]. As a building block and a redox active enzymes, the cytochrome is involved in metabolic processes in the cell. According to the National Academy of Sciences of the United States (NAS called. National Academy of Sciences), the average daily requirement for selenium (EAR- Estimated Average Requirements) and the recommended dose in the diet (RDA- Recommended Dietary Allowance) indicate selenium 45μg / day for adult women and adult man. Selenium is a trace element.

selenium; cancer; cardiovascular disease; thyroid disease

http://onkologia.org.pl/nowotwory-wprowadzenie/KRN 02.12.2017).

Woźniak J. Ludność w UE: prognoza 2008–2060. http:// egospodarka. pl/33899, Ludność w UE prognoza – 2008–2060, 1, 39, 1.html z dnia 20.03.2017 godz. 11.38.

Mastromarino V. Casenghi M. Testa M iwsp. Polypharmacy in heart failure patients. “CurrHeartFail Rep”. 11, 2014, 212-9.

Jarosz M. Normy żywienia człowieka.(red). Instytut Żywności i Żywienia. Warszawa 2017.

Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes for Calcium and Vitamin D. National Academy Press, Washington DC 2011.

Kunachowicz H, Czarnowska-Misztal E, Szczepańska A, Ners A. Podstawy żywienia człowieka. Wydawnictwo Szkolne i Pedagogiczne. Warszawa 1999.

Angielski S. Biochemia kliniczna i analityka. PZWL. Warszawa 1990.

B. Nutritional goldfinch. Practical Medicine 2000; 7 (8): 29-36.

Dietetyka, Helena Ciborowska, Anna Rudnicka. Wydawnictwo Lekarskie PZWL 2012.

Institute of Medicine, Food and Nutrition Board: Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Ntional Academy Press, Washington DC 2000.

Sunde RA. Selenium. [In:] O’Dell BL, Sunde RA et al. (eds.): Handbook of Nutritionally Essential Mineral Elements. Marcel Dekker Inc. New York 1997: 493-556.

Reilly C. Seleniu Duntas L.H., Benvega S.: Selenium: an element for life. Endocrine 2014; 48(3): 756-775 m in Food and Health. 2nd ed. Springer. London 2006.

Labunskyy V.M, Hatfield D.L, Gladyshev V.N. Selenoproteins: molecular pathways and physiological roles. Physiol. Rev. 2014; 94(3): 739-777.

Zeng H, Combs G. F. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. Journal of Nutritional Biochemistry 2008; 19: 1-7.

Gromadzińska J, Reszka E, Bruzelius K, Wąsowicz W, Åkesson B. Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur. J. Clin. Nutr. 2008; 47(2): 29-50.

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, 2000-, https://www.nap.edu/read/9810/chapter/ (17.07.2018).

Selenium and a Reduced Risk of Site-specific Cancers, FDA-2008-Q-0323, http://www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm168527.htm (17.07.2018).

Scientific Opinion on Dietary Reference Values for selenium. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 2014, 12(10), 3846.

Mangiapane E, Pessione A, Pessione E. Selenium and selenoproteins: an overview on different biological system. Curr. Protein Pept. Sci. 2014; 15(6): 598-607.

Murray RK, Granner DK, Meyes PA et al. Biochemia Harpera. Wydawnictwo Lekarskie PZWL. Warszawa 2005.

Reilly C. Selenium in Food and Health. 2nd ed. Springer. London 2006.

Hurst R, Collings R, Harvey LJ et al. EURRECA – estimating selenium requirements for deriving dietary reference values. Crit Rev Food Sci Nutr 2013; 53: 1077-1096.

U.S. Department of Health and Human Services and U.S. Department of Agriculture:2015-2020 Dietary Guidelines for Americans. 8th ed. 2015

;http://health.gov/dietaryguidelines/2015/guidelines/ (20.07.2018).

Oldfield J.E. A brief history of selenium research: From alkali disease to prostate cancer (from poison to prevention). J. Anim. Sci. Online Supplement 2002; 11: 1.

Szczygieł B. Leczenie żywieniowe. Medycyna Praktyczna 2000; 7 (8): 29–36.

Karwowska K, Hartman- Sobczyńska R, Sobczyński P. Ocena metaboliczna chorego w oddziale intensywnej terapii. Farmacja Współczesna 2011; 4: 127-132.

Kłęk S, Jarosz J, Jassem J, Kapała A, Krawczyk J, Krzakowski M, Misiak M

,Szczepanek K. Polskie Rekomendacje Żywienia Dojelitowego i Pozajelitowego w Onkologii — część II: żywienie drogą przewodu pokarmowego (żywienie dojelitowe). Onkologia w Praktyce Klinicznej 2013; 9, 6: 209–215.

Goldfinch B. Indications for nutritional therapy. Pharma Poland 1999; 55 (16):

-727.

Lyman B, Williams M, Sollazzo J. Enteral Feeding Set Handling Techniques. Nutrition in Clinical Practice 2017;32:193-200.

Pitts M.W, Burns C.N, Ogawa-Wong A.N, Kremer P, Berry M.J. Selenoproteins in Nervous System Development and Function. Biol. Trace Elem. Res 2014; 161(3): 231-245.

Brigelius-Flohé R, Maiorino M. Glutathione peroxidases. Biochim. Biophys. Acta 2013; 1830(5): 3289-3303.

Klecha B, Bukowska B. Selen w organizmie człowieka- charakterystyka pierwiastka i potencjalne zastosowanie terapeutyczne. Bromat. Chem. Toksykol

;XLIX (4):818-829.

Gromadzińska J, Reszka E, Bruzelius K, Wąsowicz W, Åkesson B. Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur. J. Clin. Nutr 2008; 47(2): 29-50.

Köhrle J, Jakob F, Contemprè B, Dumont JE: Selenium, the thyroid, and the endocrine system. Endocr Rev 2005; 26: 944-984.

Stranges S, Marshall JR, Natarajan R et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147: 217-223.

Ratajczak M, Gietka-Czernel M. Rola selenu w organizmie człowieka. Post N Med 2016;XXIX (12):929-933.

Salonen JT, Alfthan G, Pikkarainen J et al. Association between cardiovascular death and myocardial infarction in a matched pair longitudinal study. Lancet 1982; 2: 175-179.

Zagrodzki P. Selen, a układ odpornościowy. Postępy Hig Med. Dosw 2004;58:140-149.

Zagrodzki P, Kryczyk J. Znaczenie selenu w chorobie Hashimoto. Postępy Hig. Med 2014;68:1128-1137.

Bartosz G. Druga twarz tlenu. Wolne rodniki w przyrodzie. Wyd. I. Wydawnictwo Naukowe PWN. Warszawa 2008.