Fatal pesticide intoxication - case report of a 2 patients

Jędrzej Tkaczyk, Klaudia Brożyna, Krystian Ciechański, Agnieszka Radzka, Michał Tchórz


Pesticides is a collective term for a group of chemicals used predominantly in agriculture and against vectors in vectorborne diseases such as malaria, filariasis, etc. Organophosphates (OP) have become nowadays the most widely used pesticides among the world. However, they are very highly toxic to humans. Poisoning with OP is a life - threatening condition. It is responsible for the symptoms due to a cholinergic effects. The Acetylcholinesterase (ACHE) enzyme inhibition leads to an acetylcholine accumulation, which causes symptoms such as diarrhea, sweating, vomiting, small pupils, muscle tremors, increased saliva and tears production and confusion. Other type of pesticides are also common used in agriculture. Glyphosate is a broad‐spectrum systemic herbicide used to kill weeds. It is promoted by the manufacturer as having no risks to human health.
We present two patients with a fatal pesticide poisoning. First patient drank OP agent, which was decanted in a non-original bottle. Despite the intensive treatment, including high doses of atropine, and toxogonine, patient died after 6 days due to acute respiratory failure. The second one, tried to commit suicide by drinking 2 glasses of a pesticide called ‘Roundap’ (glyphosate). Short time after admission to a hospital, a myocardial infarction occurred. The patient died the same day, due to a cardiac arrest.


organophosphates; intoxication; toxicology

Full Text:



Jeyaratnam J. Acute pesticide poisoning: a major global health problem. World Health Stat Q 1990; 43: 139-44.

Jeyaratnam J. Health problems of pesticide usage in the Third World. Br J Ind Med. 1985;42:505–506.

Bertolote JM, Fleischmann A, Butchart A, Besbelli N. Suicide, suicide attempts and pesticides: a major hidden public health problem. Bull World Health Organ. 2006;84:260.

Coskun R, Gundogan K, Sezgin G C, Topaloglu U S, Hebbar G, Guven M, Sungur M. A retrospective review of intensive care management of organophosphate insecticide poisoning: Single center experience. Niger J Clin Pract 2015;18:644-50

Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning. Lancet 2008;371:597-607.

Lotti, M. Clinical toxicology of anticholinesterase agents in humans. in: R Krieger (Ed.)Handbook of pesticide toxicology. Volume 2. Agents. 2 edn. Academic Press, San Diego; 2001: 1043–1085

Clark, RF. Insecticides: organic phosphorus compounds and carbamates. in: Goldfrank's Toxicological Emergencies. 7th edn. McGraw-Hill Professional, New York; 2002: 1346–1360

Nicole M. Roy, Jeremy Ochs, Ewelina Zambrzycka, Ariann Anderson, Glyphosate induces cardiovascular toxicity in Danio rerio, Environmental Toxicology and Pharmacology. 2016; 46:292-300.

Lavy T, Cowell J, Steinmetz J, Massey J. Conifer seedling nursery worker exposure to glyphosate. Arch Environ Contam Toxicol 1992; 22:6–13.

Williams GM, Kroes R, Munro IC. Safety evaluation and risk assessment of the herbicide roundup and its active ingredient, glyphosate, for humans. Regul Toxicol Pharmacol 2000; 31:117–165.

Kim YH, Lee JH, Hong CK et al. Heart rate‐corrected QT interval predicts mortality in glyphosate–surfactant herbicide‐poisoned patients. Am J Emerg Med 2014; 32: 203–207.

Lee H.L., Chen K.W. ,Ch C.H. i, Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases, Acad Emerg Med, 2000;7:906-910

Moon JM, Min YI, Chun BJ: Can early hemodialysis affect the outcome of the ingestion of glyphosate herbicide? Clin Toxicol (Phila) 2006,44(3):329–332.

Singh D, Jit I, Tyagi S. Changing trends in acute poisoning in Chandigarh zone: a 25-year autopsy experience from a tertiary care hospital in northern India. Am J Forensic Med Pathol 1999;20:203–210.

Przybylska A: Zatrucia chemicznymi środkami ochrony roślin w 2000 roku. Przegl Epidemiol 2002; 56: 311-7.

Byung Kook Lee, Kyung Woon Jeung, Hyoung Youn Lee & Yong Hun Jung. Mortality rate and pattern following carbamate methomyl poisoning. Comparison with organophosphate poisoning of comparable toxicity, Clinical Toxicology. 2011;49:9, 828-833.

Roberts DM, Buckley NA, Mohamed F, et al. A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning. Clinical toxicology (Philadelphia, Pa). 2010;48(2):129-136.

Giyanwani PR, Zubair U, Salam O, Zubair Z. Respiratory Failure Following Organophosphate Poisoning: A Literature Review. Muacevic A, Adler JR, eds. Cureus. 2017;9(9):e1651.

M John, A Oommen, A Zachariah, Muscle Injury in Organophosphorous Poisoning and Its Role in the Development of Intermediate Syndrome, NeuroToxicology, 2003;24:1,43-53.

DOI: http://dx.doi.org/10.5281/zenodo.1246007


  • There are currently no refbacks.

Copyright (c) 2018 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014


POL-index 2011 - 2014


BASE 2011 - 2014




Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI


Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland






Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.


ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski