Antiinflammation and antidsbiotic actions of flavancontent means on rat colon mucosa after received the peroxide sunflower oil

A. V. Bocharov


Aim: To determine prophylactics action of flavancontent means after introduction the peroxide sunflower oil.

Materials and methods: Its were used flavancontent means: quertulin (quercetin + inulin + Ca citrate), lequin (lecithin + quercetin + inulin + Ca citrate) and lecasil (lecithin + flavolignan from Silybum marianum + Ca citrate). Rats received peroxide sunflower oil (PSO) per os in dose 1 ml/rat day. The flavancontent means introduced every day in dose 300 mg/kg in during 2,5 months. The activities elastase, urease, lysozyme, catalase and content of MDA were determined into colon mucosa.

Results: The activities elastase, urease and content of MDA were increased in rats, what received PSO, but activity of lysozyme was reduced. The flavancontent means were lowered the activities of elastase and content of MDA, but was increased activity lysozyme.

Conclusion: PSO made dysbiosis and inflammation into colon mucosa. The flavancontent means made prophylactic action, better lequin and lecasil.


colon, lipid peroxide product, dysbiosis, flavancontent means, lecithin, prophylactics of colitis

Full Text:



Levitsky AP, Makarenko OA, Pochtar' VN et al. Perekisnaja model' stomatita [The peroxide model of stomatitis]. Visnyk stomatologii', 2005;4:7–10. (in Russian)

Lushhak VI, Bagnjukova TV, Luzhna LI. Pokazniki oksidativnogo stresu. Peroksidi lіpіdіv: metodi [Indicators of oxidative stress. Lipid Peroxides: Methods]. Ukrai'ns'kyj biohimichnyj zhurnal, 2006;6:113–129. (in Ukrainian)

Unger RH. Lipotoxic Diseases. Annu. Rev. Med., 2002;53:319–336.

Mokdad AH, Ford ES, Bowman BA. et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA, 2003;289(1):76–79.

Day C. P. From fat to inflammation. Gasrtoenterology, 2006;130:207–210.

Men'shhikova EB, Lankin VZ, Zenkov NK et al. Okislitel'nyj stress. Prooksidanty i antioksidanty [The oxidative stress. Prooxidants and antioxidants]. Moskva, Slovo, 2006:556. (in Russian)

Romancova TI. Epidemija ozhirenija: ochevidnye i verojatnye prichiny [The obesity epidemic: truthful and veritable reasurs]. Ozhirenie i metabolism, 2011;1:1–14. (in Russian)

Levitsky AP, Makarenko OA, Selivanskaya IA et al. Kvertulin. Vitamin P, prebiotik, gepatoprotektor [“Querthulin”, Vitamin P, prebiotic, hepatoprotector]. Оdеssа, KP OGT, 2012:20. (in Russian)

TU U 10.8-13903778-040:2012 «Dietary "Kvertulin». Vysnovok MOZU № 05.03.02-06/44464 vid 17.05.2012. (in Russian)

Levitsky AP, Makarenko OA, Selivanskaya IA et al. Antidysbiotic preparation “Lekvin”. Patent of Ukraine 108536. IPC (2016.01) А61К 36/00, А61Р 3/00. Date of filling: 23.12.2015. Publ.: 25.07.2016. Bul. № 14. . (in Ukrainian)

TU U 10.8-37420386-003:2016 «Dietary «Lekvin». Vysnovok MOZU № 05.03.02-06/8400 vid 21.03.2016. (in Ukrainian)

TU U 10.8-37420386-005:2017 «Dietary «Lekasil». Vysnovok MOZU № 602-123-202/12102 vid 25.04.2017. (in Ukrainian)

Levitsky AP, Shnajder SA, Skiba VJa et al. Eksperimental'nye metody vosproizvedenija stomatita: metodicheskie rekomendacii [The experimental methods of stomatitis reproduction: method guidelines]. Odessa, KP OGT, 2015:19. (in Russian)

Levitsky AP, Denga OV, Makarenko OA et al. Biokhimicheskie markery vospaleniya tkaney rotovoy polosti: metodicheskie rekomendatsii [Biochemical markers of inflammation of oral cavity tissue: method guidelines]. Оdеssа, KP OGT, 2010:16. (in Russian)

Gavrikova LM, Segen IT. Ureaznaia aktivnost rotovoi zhidkosti u bolnykh s ostroi odontogennoi infektsiei cheliustno-litsevoi oblasti [Urease activity of oral liquid in patients with acute odontogenic infection of maxillo-facial part]. Stomatologiya, 1996; The extra issue:49–50. (in Russian)

Levitsky AP. Lizotsym vmesto antibiotikov [Lysozyme instead of antibiotics]. Оdеssа, KP OGT, 2005:74. (in Russian)

Levitsky AP, Denga OV, Selivanskaya IA et al. The method of estimation of the degree of dysbiosis (dysbacteriosis) of organs and tissues. Patent of Ukraine 43140. IPC (2009) G01N 33/48. Application number u 200815092. Date of filling: 26.12.2008. Publ.: 10.08.2009. Bul. № 15. (in Ukrainian)

Lapach SN, Chubenko AV, Babich PN. Statisticheskiye metody v medico-biologicheskikh issledovaniyakh s ispolzovaniem Excel [Statistical methods in medical and biological research by using Excel]. Kiev, Morion, 2000:320. (in Russian)



  • There are currently no refbacks.

Copyright (c) 2017 The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski