β-Hydroxy β-methylbutyrate (HMB) supplementation during pregnancy and perinatal period in animals studies and possible application in humans

Dominika Cieślak, Barbara Nieradko-Iwanicka

Abstract


β-Hydroxy β-methylbutyrate (HMB) is a diet supplement known for its positive impact on muscle anabolism, which makes it very popular among amateur sportsmen. Diet enriched with HMB leads to decreased proteolysis in muscle tissue, which is extremely important in the process of muscle regeneration after intensive training. As the number of possible implications of this molecule in medicine is still growing, the aim of this review was to find potential applications of HMB in women and their infants during pregnancy and perinatal period.

 

The HMB usage during pregnancy or shortly after birth is connected with increased muscle anabolism in the infants. Many factors like mTOR signaling pathway, increased activity of GH/IGF-1 axis or elevated blood concentration of some amino acids may be responsible for this effect. Such activity might be potentially helpful for infants born with intrauterine growth retardation (IUGR). Improvement in quality and quantity of colostrum and milk, positive impact on bones and cartilages or immunostimulating effect and deceased enamel roughness, which potentially reduces the risk of caries, are other potential benefits. Although numerous possible positive effects have been postulated, there seems to be insufficient data on safety of long term HMB supplementation, especially in pregnancy and perinatal period. Moreover, there are studies that imply increased peripheral insulin resistance after prolonged supplementation of HMB.

 

HMB usage can be beneficial in numerous health states, also in pregnancy and perinatal period, especially in infants with low birth weight or born preterm, but further investigation is needed to estimate benefits to risk ratio and introduce specific guidelines.


Keywords


β-Hydroxy β-methylbutyrate supplementation; low birth weight; muscle metabolism; prenatal programming

Full Text:

PDF

References


Van Koevering M, Nissen S. Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo. Am J Physiol-Endocrinol Metab. 1992;262(1):E27–E31.

Rowlands DS, Thomson JS. Effects of β-hydroxy-β-methylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: A meta-analysis. J Strength Cond Res. 2009;23(3):836–846.

Jones MS, Rivera M, Puccinelli CL, Wang MY, Williams SJ, Barber AE. Targeted Amino Acid Supplementation in Diabetic Foot Wounds: Pilot Data and a Review of the Literature. Surg Infect. 2014;15(6):708–12.

Fitschen PJ, Wilson GJ, Wilson JM, Wilund KR. Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations. Nutrition. 2013;29(1):29–36.

Nunes EA, Kuczera D, Brito GAP, Bonatto SJR, Yamazaki RK, Tanhoffer RA, et al. β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-κB expression. Nutr Res. 2008;28(7):487–93.

Wójcik R, Małaczewska J, Siwicki AK, Miciński J, Zwierzchowski G. The effect of β-hydroxy-β-methylbutyrate (HMB) on selected parameters of humoral immunity in calves. Pol J Vet Sci. 2014;17(2).

Yonamine CY, Teixeira SS, Campello RS, Gerlinger-Romero F, Rodrigues CF, Guimarães-Ferreira L, et al. Beta hydroxy beta methylbutyrate supplementation impairs peripheral insulin sensitivity in healthy sedentary Wistar rats. Acta Physiol. 2014;212(1):62–74.

Gerlinger-Romero F, Guimarães-Ferreira L, Giannocco G, Nunes MT. Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats. Growth Horm IGF Res. 2011;21(2):57–62.

Baxter JH, Carlos JL, Thurmond J, Rehani RN, Bultman J, Frost D. Dietary toxicity of calcium β-hydroxy-β-methyl butyrate (CaHMB). Food Chem Toxicol. 2005;43(12):1731–41.

Tomaszewska E, Dobrowolski P, Kostro K, Jakubczak A, Taszkun I, Jaworska-Adamu J, et al. Effect of HMB and 2-Ox administered during pregnancy on bone properties in primiparous and multiparous minks (Neivison vison). Bull Vet Inst Pulawy. 2015;59(4).

Kovacs CS. Calcium Metabolism during Pregnancy and Lactation. In: Groot LJD, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, et al., Eds. Endotext. MDText.com, Inc.; 2000.

Michaëlsson K, Baron JA, Farahmand BY, Ljunghall S. Influence of parity and lactation on hip fracture risk. Am J Epidemiol. 2001;153(12):1166–1172.

Świetlicka I, Muszyński S, Tomaszewska E, Dobrowolski P, Kwaśniewska A, Świetlicki M, et al. Prenatally administered HMB modifies the enamel surface roughness in spiny mice offspring: An atomic force microscopy study. Arch Oral Biol. 2016;70:24–31.

Wan H, Zhu J, Shen Y, Xiang X, Yin H, Fang Z, et al. Effects of Dietary Supplementation of β -hydroxy- β -methylbutyrate on Sow Performance and mRNA Expression of Myogenic Markers in Skeletal Muscle of Neonatal Piglets. Reprod Domest Anim. 2016;51(1):135–42.

Tatara MR, Krupski W, Tymczyna B, Studziński T. Effects of combined maternal administration with alpha-ketoglutarate (AKG) and β-hydroxy-β-methylbutyrate (HMB) on prenatal programming of skeletal properties in the offspring. Nutr Metab. 2012;9(1):39.

Flummer C, Kristensen NB, Theil PK. Body composition of piglets from sows fed the leucine metabolite β-hydroxy β-methyl butyrate in late gestation. J Anim Sci. 2012;90(Supplement 4):442–444.

Blicharski T, Tomaszewska E, Dobrowolski P, Hułas-Stasiak M, Muszyński S. A metabolite of leucine (β-hydroxy-β-methylbutyrate) given to sows during pregnancy alters bone development of their newborn offspring by hormonal modulation. PloS One. 2017;12(6):e0179693.

Flummer C, Theil PK. Effect of β-hydroxy β-methyl butyrate supplementation of sows in late gestation and lactation on sow production of colostrum and milk and piglet performance. J Anim Sci. 2012;90(Supplement 4):372–374.

Wan H, Zhu J, Wu C, Zhou P, Shen Y, Lin Y, et al. Transfer of β-hydroxy-β-methylbutyrate from sows to their offspring and its impact on muscle fiber type transformation and performance in pigs. J Anim Sci Biotechnol. 2017;8(1).

Schiaffino S, Reggiani C. Fiber Types in Mammalian Skeletal Muscles. Physiol Rev. 1 October 2011;91(4):1447–531.

Wan H, Zhu J, Su G, Liu Y, Hua L, Hu L, et al. Dietary supplementation with β-hydroxy-β-methylbutyrate calcium during the early postnatal period accelerates skeletal muscle fibre growth and maturity in intra-uterine growth-retarded and normal-birth-weight piglets. Br J Nutr. 2016;115(08):1360–9.

Wheatley SM, El-Kadi SW, Suryawan A, Boutry C, Orellana RA, Nguyen HV, et al. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of -hydroxy- -methylbutyrate. AJP Endocrinol Metab. 2014;306(1):E91–9.

MuğLali ÖH, Salman M, Gacar A, Akdağ F, GüLbahar MY, çIftçI A, et al. In ovo feeding with β-hydroxy β-methylbutyrate and broilerperformance, intestinal health, and immunity status. Turk J Vet Anim Sci. 2016;40:28–33.

Tako E, Ferket PR, Uni Z. Effects of in ovo feeding of carbohydrates and beta-hydroxy-beta-methylbutyrate on the development of chicken intestine. Poult Sci. 2004;83(12):2023–2028.

Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, et al. The role of leucine and its metabolites in protein and energy metabolism. Amino Acids. 2016;48(1):41–51.

Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009;122(20):3589–94.

Kopec G, Shekhawat P, Mhanna M. Prevalence of diabetes and obesity in association with prematurity and growth restriction. Diabetes Metab Syndr Obes Targets Ther. 2017;10:285–95.

Singhal A. Long-Term Adverse Effects of Early Growth Acceleration or Catch-Up Growth. Ann Nutr Metab. 2017;70(3):236–40.




DOI: http://dx.doi.org/10.5281/zenodo.1183841

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)