Changes of ceruloplasmin`s activity in animals` bronchi in late periods of experimental allergic alveolitis development and their correction with thiotriasolin

Mariana Ljubomurivna Baida


The present study has shown that thiotriazolin possess to moderate antiinflammatory and antioxidant activities.An imbalance between generation of free radicals and antioxidant defences leads to a negative condition known as oxidative stress. Pulmonary damage caused by oxygen toxicity occurs due to the generation of reactive oxygen species and subsequent formation of more potent oxidants. Additionally, treatment with thiotriasolin has modulated enzymatic level of ceruloplasmin. The study of oxidative stress in the pathogenesis of exogenic allergic alveolitis could open new therapeutic horizons. 


experimental allergic alveolitis, peroxide lipid oxidation, ceruloplasmin, thiotriazolin

Full Text:



Braz J Med Biol Res. 2004 Feb;37(2):185-92. Epub 2004 Jan 30. Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress.

Torres RL, Torres IL, Gamaro GD, Fontella FU, Silveira PP, Moreira JS, Lacerda M, Amoretti JR, Rech D, Dalmaz C, Belló AA.

Costabel U, Bonella F, Guzman J. Chronic hypersensitivity pneumonitis. Clin Chest Med. 2012;33:15163.

Selman M, Pardo A, King TE Jr. Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med. 2012;186:314-24.

Spagnolo P, Richeldi L, du Bois RM. Environmental triggers and susceptibility factors in idiopathic granulomatous diseases. Semin Respir Crit Care Med. 2008;29:610-9.

Thomeer MJ, Costabe U, Rizzato G, Poletti V, Demedts M. Comparison of registries of interstitial lung diseases in three European countries. Eur Respir J Suppl. 2001;32:114s-118s.

Coultas DB, Zumwalt RE, Black WC, Sobonya RE. The epidemiology of interstitial lung diseases. Am J Respir Crit Care Med. 1994;150:967-72.

Dalphin JC, Manzoni P, Ranfaing E, Reboux G. Bronchial involvement in hypersensitivity pneumonitis. Presse Med. 2009;64:322-34.

Walsh SL, Sverzellati N, Devaraj A, Wells AU, Hansell DM. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. Eur Radiol. 2012;22:1672

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 14. Mechanisms and Consequences of Oxidative Stress in Lung Disease: Therapeutic Implications for an Aging Populace. Hecker L.

Orekhov O. O. Patomorfologiya legkikh i mikrotsirkulyatornogo rusla malogo kruga krovoobrashcheniya pri khronicheskom eksperimental'nom allergicheskom al'veolite / O. O. Orekhov, YU. A. Kirilov // Arkhiv patologii.– 1985.– № 10.– S. 54–61. [in Rusian]

Gavrilov A.B., Myshkorudnaya M.I. Spektrofotometricheskoye opredeleniye soderzhaniya gidroperekisey lipidov v plazme. Laboratornaya diagnostika ishemicheskoy bolezni serdtsa, - K.: Zdorov'ya, 1989,170-171[in Rusian]

Korobeynikov E.N. Modifikatsiya opredeleniya produktov POL v reaktsii s tiobarbiturovoy kislotoy Lab. delo 1989,7,8-10[in Rusian]

Kolb V. G. Opredeleniye aktivnosti tseruloplazmina v krovi / V. G. Kolb, V. S. Kamyshnikov // Spravochnik po klinicheskoy khimii.– Minsk: Bela rus', 1982.– S. 290–291 [in Rusian]



  • There are currently no refbacks.

Copyright (c) 2017 © The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski