Research of lipid exchange diffusion of medium-age patients with chronic pancreatitis with diabetes mellitus

L. S. Babinets, N. A. Shevchenko, H. N. Sasyk, O. S. Zemlyak


Chronic pancreatitis refers to diseases in which both excretoric and incretoric sections of the pancreas are damaged, which in later stages leads to the development of concomitant diabetes mellitus (DM), which are not sufficiently studied in this pathology. This article presents a study of lipid metabolism in patients with chronic middle-aged pancreatitis with concomitant diabetes. It has been proved that the presence of DM significantly complicated the clinical course of chronic pancreatitis (CP) in the ballistic system M - ANNHEIM, which correlated with changes in the program (r=0,67; p<0,001), the criteria for ultrasound (r=0,54; p<0,01), the level of glycosylated hemoglobin (r=0,66; p<0,001). In patients with CP with concomitant diabetes the severity of the disease was more pronounced than in patients with CP: the average severity (C) predominated in 69,56% of patients in group 2, with 26,32% of the 1st, and cases of severe and severe severity. A direct reliable correlation between all the atherogenic indicators of the lipidogram and the age of the patients and the duration of the course of the CP were found, which makes it possible to assume the age and duration of the CP by factors of the deepening of the dyslipidemia. In patients with CP in combination with DM and dyslipidemia, the lower index of fecal α-elastase level was established in comparison with the CP group: (157,15 ± 7,36) versus (112,86 ± 2,98), respectively (p<0,001) which proved a deepening of dyslipidemia in the development of excretory insufficiency of the pancreas.


chronic pancreatitis, diabetes mellitus, middle age, dyslipidemia, fecal α-elastase

Full Text:



Babinets' LS. Analiz vplyvu riznykh etiolohichnykh chynnykiv na vynyknennya khronichnoho pankreatytu [Analysis of the influence of various etiological factors on the occurrence of chronic pancreatitis] // Visnyk Vinnyts'koho derzh. med. universytetu. 2003: 7(2/1); 444–445.

Babinets' LS., Mihen'ko LM. Porushennya lipidnoho obminu v patohenezi khronichnoho pankreatytu[Infringement of lipid metabolism in the pathogenesis of chronic pancreatitis] // Visnyk Klubu Pankreatolohiv. 2012: 3 (16); 23–25.

Vinokurova LV. Kliniko-patogeneticheskie mekhanizmy razvitiya vneshne – i vnutrisekretornoy nedostatochnosti pri khronicheskom pankreatite [Clinical and pathogenetic mechanisms of development of external and intracerebral insufficiency in chronic pancreatitis] Avtoref. diss... d-ra med. nauk:14.00.47 / Moskva. 2009; 24 s.

Gubergrits NB. Novaya mezhdunarodnaya klassifikatsiya khronicheskogo pankreatita [New international classification of chronic pancreatitis] Vestnik Kluba Pankreatologov. 2008: 1(2);10–25.

Rebrov AP., Kunitsyna MA., Kashkina EI., Arkhangel'skaya EE. Pankreatogennyy sakharnyy diabet: aktual'nye problemy patogeneza i lecheniya[Pancreatogenic diabetes mellitus: current pathogenesis and treatment problems] (obzor). Saratovskiy nauchno-meditsinskiy zhurnal. 2012: 8(3); 862–867.

Suchasni klasyfikatsiyi ta standarty likuvannya rozpovsyudzhenykh zakhvoryuvan' vnutrishnikh orhaniv [Modern classifications and standards for the treatment of widespread diseases of the internal organs] za red. Yu.M. Mostovoho. – 15-te vyd. dop. i pererob. – Vinnytsya, 2016; 535 s.

Meier JJ., Menge BA., Breuer TG., Müller CA. [at al.]. Functional assessment of pancreatic b-cell area in humans. Diabetes. 2009: 58(7); P. 1595–1603.

Niebisz–Cieślak AB., Karnafel W. Insulin sensitivity in chronic pancreatitis and features of insulin resistance syndrome. Pol. Arch. Med. Wewn. 2010: 120(8); 255–263.

Schrader H., Menge BA., Zeidler C., Ritter PR., [at al.]. Determinants of glucose control in patients with chronic pancreatitis. Diabetologia. 2010: 53(6); 1062–1069.

Schneider A. Lohr J.M., Singer M.V. The M–ANNHEIN — classification of chronic pancreatitis: Introduction of a unifying classification system based on review of previous classification of the disease. J. Gastroenterol. 2007: 42(2); 101–119.



  • There are currently no refbacks.

Copyright (c) 2017 © The Author (s) 2017

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:

Journal Language(s): English 

PBN Poland



Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2 Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase


Universal Impact Factor 1.78 for year 2012. (

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski