Histoenzymic determination of activity of alkaline phosphatase and succinate dehydrogenase in the renal tissue of rats at NADP administration on the background of 31-days experimental diabetes mellitus

M. I. Grytsiuk


The article presents data on the activity of some enzymes of rats’ renal tissue in experimental diabetes mellitus in the early period of its formation. It was found that at 31 days of the experiment, the administration of NADP significantly increases the activity of ALP by more than twice, thereby improving the functioning of the proximal tubules in particular, and restores almost normal SDH activity, which allows us to assume that the positive metabolic effects of NADP are not only at the level of general metabolism, but also specifically at the organ level - the kidneys.


diabetes mellitus, streptozotocin, alkaline phosphatase, succinate dehydrogenase

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Tkachenko VI. Analiz poshyrenosti ta zakhvoryuvanosti na tsukrovyy diabet sered naselennya svitu ta Ukrayiny za 2003-2013 rr. Liky Ukrayiny. 2014;4(21):55-9.

Bequer L, Gómez T, Molina JL. Streptozotocin diabetogenic action in an experimental neonatal induction model. Biomedica. 2016;36(2):230-8.

Afanas'ev S.A. Comparative study of changes in energy metabolism in rat cardiomyocytes in postinfarction cardiosclerosis and diabetes mellitus / S.A Afanas'ev, D.S. Kondrat'eva , M.V. Egorova, S.V. Popov // Bull Exp Biol Med. – 2013. – №156(V.2). – P. 185-187.

Gavaleshko V.P. Histological changes in kidneys at diabetes mellitus, complicated by partial global ischemia-reperfusion / V.P. Gavaleshko // Clinical Anatomy and Operative Surgery – 2012. – V.11, №3. – P. 62-65.

Galenova Т.І. The modeling of experimental streptozotocin-induced II type diabetes in rats / Т.І. Galenova, V.V. Konopelniuk, О.М. Savchuk, L.І. Ostapchenko // Physics of Alive. – 2010. – V.18, №3. – P. 50-54.

Davydenko І.S Histochemical peculiarities of oxidative modification of proteins in glomeruli cells at acute postinfectional glomerulonephritis / І.S. Davydenko,

О.М. Davydenko // Bukovinian Medical Journal. – 2012. – V.16, №3 (63). – Part 2. – P. 106-108.

Loboda О.М. Mechanism of development and progression of diabetic nephropathy / О.М. Loboda, І.О.Dudar, V.V. Аlekseeva // Clinical Immunology. Allergology. Іnfectology. – 2010. – №9-10 (38-39). – P. 46-50.

Maidannyk V.G. Molecular mechanisms of kidneys’ damage at diabetes mellitus in children (review article) / V.G. Maidannyk, Ye.А. Burlaka // Pediatrics, Obstetrics and Gynecology. – 2010. - №3. – P. 34-47.

Rebrov B.А. Kidneys’ damage at diabetes mellitus / B.А. Rebrov // International Endocrinology Journal. – 2011. – № 2(34). – P. 51-55.

Scrobonska N.А. Diabetic nephropathy: some untraditional factors of pathogenesis, main ways of diagnostics and treatment (review article and personal results) / N.А. Scrobonska, Т.S. Tcymbal // Family Medicine. – 2011. - №4. – P. 18-22.

Hutorska L.А. Prevalence, absolute and relative risk of the development of diabetic nephropathy in patients with diabetes mellitus / L.А. Hutorska // Bukovinian Medical Journal. – 2012. – V.16, №4(64). – P. 170-174.

Shularenko L.V. Chronical diabetic renal disease: modern view on the problem / L.V. Shularenko // Endocrinology. – 2013. – Vol. 18, No 1. –P. 73-82.

The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats / Mingua Zhang, Liang Feng, JunfeiGu [et al.] // Oxidative Medicine and Cellular Longevity. – 2014. – Vol.18.– P. 1-13.

Dranovalli S. The Pathogenesis of Diabetic Nephropathy / S. Dranovalli, I. Duka, G.L. Bakris // Nat. Clin. Pract. Endocrinol. Metab. – 2008. – N.2. – P. 444-452.

DOI: http://dx.doi.org/10.5281/zenodo.1119068


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