Influence of complex treatment with quercetin inclusion on cytokine profile indicators in chronic nonviral hepatitis patients

V. P. Prysyazhnyuk


The influence of treatment with quercetin inclusion on the clinical and biochemical course and the cytokine profile of chronic nonviral hepatitis patients have been studied. In addition to the basic therapeutic treatment quercetin intake led to the decrease in the cytolytic and cholestatic syndromes activities which were manifested by a faster regression of clinical signs of the disease. During two weeks of treatment chronic hepatitis patients who received quercetin in addition to standard treatment, showed decrease in proinflammatory tumor necrosis factor-α by 61,9% (p = 0,02) and a marker of early cardiovascular injury atrial natriuretic propeptide in the blood by 53,8% (p = 0,04). However, according to the data obtained, it is clear that for a complete correction of clinical manifestations of the disease, biochemical changes and the cytokine profile two-week appointment of complex treatment with quercetin inclusion is not enough, which requires longer administration of the chosen treatment course before the onset of persistent remission at the out-patient stage.


chronic hepatitis, quercetin, tumor necrosis factor-α, interleukin-10, atrial natriuretic propeptide

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Brenner C, Galluzzi L, Kepp O, Kroemer G. Decoding cell death signals in liver inflammation. J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033.

Chen Q, Wang T, Li J, Wang S, Qiu F, Yu H, et al. Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). Nutrients. 2017 Jan 31;9(2): E96. doi: 10.3390/nu9020096.

Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85. doi: 10.2174/187152810793358741.

Cillo U, Bassanello M, Lancerin F, Senzolo M, Burra P, Brolese A, et al. Physiological and clinical implications of proANP(1-98) circulating levels in the perioperative phase of liver transplantation. Clin Chim Acta. 2001;310:39-48.

Cintra DE, Pauli JR, Araújo EP, Moraes JC, de Souza CT, Milanski M, et al. Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol. 2008 Apr;48(4):628-37. doi: 10.1016/j.jhep.2007.12.017.

El-Emshaty HM, Nasif WA, Mohamed IE. Serum cytokine of Il-10 and Il-12 in chronic liver disease: the immune and inflammatory response. Dis Markers. 2015;2015:707254. doi: 10.1155/2015/707254.

Gleeson D, Bradley MP, Jones J, Peck RJ, Bond SK, Teare MD, et al. Cytokine gene polymorphisms in heavy drinkers with and without decompensated liver disease: a case-control study. Am J Gastroenterol. 2008 Dec;103(12):3039-46. doi: 10.1111/j.1572-0241.2008.02150.x.

Goto S, Deguchi J, Nishio N, Nomura N, Funabashi H. Hepatotoxicants induce cytokine imbalance in response to innate immune system. J Toxicol Sci. 2015 Jun;40(3):389-404. doi: 10.2131/jts.40.389.

Kelly GS. Quercetin. Altern Med Rev. 2011 Jun;16(2):172-94.

Liedtke C, Trautwein C. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. Eur J Cell Biol. 2012 Jun-Jul;91(6-7):582-9. doi: 10.1016/j.ejcb.2011.10.001.

Marcos M, Gómez-Munuera M, Pastor I, González-Sarmiento R, Laso FJ. Tumor necrosis factor polymorphisms and alcoholic liver disease: A HuGE Review and Meta-Analysis. Am J Epidemiol. 2009 Oct 15;170(8):948-56. doi: 10.1093/aje/kwp236.

Montoliu C, Kosenko E, Del Olmo JA, Serra MA, Rodrigo JM, Felipo V. Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. Liver International. 2005;4:787-95.

Sheremeta LM. [Investigation of hepatoprotective action of liposomal quercetin in experimental hepatitis]. Halytskyy likarskyy visnyk. 2005;1:68-9.

Won IL, Jeong BG. Innate immunity and alcoholic liver fibrosis. J Gastroenterol Hepatol. 2008 Mar; 23(Suppl 1): S112–S118. doi: 10.1111/j.1440-1746.2007.05274.x.



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