The article presents data on the activity of some enzymes of rats’ renal tissue in experimental diabetes mellitus in the early period of its formation. It was found that at 11 days of the experiment, the activity of enzymes alkaline phosphatase and succinate dehydrogenase, both in streptotrozine-induced diabetes mellitus and in the introduction of NADP, did not change much, suggesting that the registered changes are adaptive in their nature.

Afanas'ev S.A. Comparative study of changes in energy metabolism in rat cardiomyocytes in postinfarction cardiosclerosis and diabetes mellitus / S.A Afanas'ev, D.S. Kondrat'eva , M.V. Egorova, S.V. Popov // Bull Exp Biol Med. – 2013. – №156(V.2). – P. 185-187.

Gavaleshko V.P. Histological changes in kidneys at diabetes mellitus, complicated by partial global ischemia-reperfusion / V.P. Gavaleshko // Clinical Anatomy and Operative Surgery – 2012. – V.11, №3. – P. 62-65.

Galenova Т.І. The modeling of experimental streptozotocin-induced II type diabetes in rats / Т.І. Galenova, V.V. Konopelniuk, О.М. Savchuk, L.І. Ostapchenko // Physics of Alive. – 2010. – V.18, №3. – P. 50-54.

Davydenko І.S Histochemical peculiarities of oxidative modification of proteins in glomeruli cells at acute postinfectional glomerulonephritis / І.S. Davydenko, О.М. Davydenko // Bukovinian Medical Journal. – 2012. – V.16, №3 (63). – Part 2. – P. 106-108.

Loboda О.М. Mechanism of development and progression of diabetic nephropathy / О.М. Loboda, І.О.Dudar, V.V. Аlekseeva // Clinical Immunology. Allergology. Іnfectology. – 2010. – №9-10 (38-39). – P. 46-50.

Maidannyk V.G. Molecular mechanisms of kidneys’ damage at diabetes mellitus in children (review article) / V.G. Maidannyk, Ye.А. Burlaka // Pediatrics, Obstetrics and Gynecology. – 2010. - №3. – P. 34-47.

Rebrov B.А. Kidneys’ damage at diabetes mellitus / B.А. Rebrov // International Endocrinology Journal. – 2011. – № 2(34). – P. 51-55.

Scrobonska N.А. Diabetic nephropathy: some untraditional factors of pathogenesis, main ways of diagnostics and treatment (review article and personal results) / N.А. Scrobonska, Т.S. Tcymbal // Family Medicine. – 2011. - №4. – P. 18-22.

Bodnar I.А. Role of glomeruli cells dysfunction in the development of diabetic nephropathy / I.А. Bodnar, V.V. Кlymontov // Problems of Endocrinology. – 2006. – V.52, №4. – P. 45-49.

Hutorska L.А. Prevalence, absolute and relative risk of the development of diabetic nephropathy in patients with diabetes mellitus / L.А. Hutorska // Bukovinian Medical Journal. – 2012. – V.16, №4(64). – P. 170-174.

Shularenko L.V. Chronical diabetic renal disease: modern view on the problem / L.V. Shularenko // Endocrinology. – 2013. – Vol. 18, No 1. –P. 73-82.

The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats / Mingua Zhang, Liang Feng, JunfeiGu [et al.] // Oxidative Medicine and Cellular Longevity. – 2014. – Vol.18.– P. 1-13.

Dranovalli S. The Pathogenesis of Diabetic Nephropathy / S. Dranovalli, I. Duka, G.L. Bakris // Nat. Clin. Pract. Endocrinol. Metab. – 2008. – N.2. – P. 444-452.

Gohzenko А.I. Osnovy postroyeniya teorii bolezni [The basis of the theory of the disease] Моnografiya. – Оdessa. «Feniks». – 2015. – 84 s. (in Russian)

Коlesnik М.О. Diabetychna nefropatiya: up to date (Chastyna 1) [Diabetic Nephropathy: up to date (Part 1)] Therapia. – 2015. - №12(104). – S. 13-17. (in Ukrainian)