New approaches in the treatment of patients with locally advanced breast cancer

O. V. Bondar

Abstract


The problem of breast cancer (BC) becomes more urgent every year, which is characterized by an increase in the annual morbidity with this disease and rejuvenation of this pathology. BC is a leader in the structure of morbidity, so it is a very urgent task to develop new methods of treatment of this disease. Statistical data show a steady increase in the incidence of breast cancer in the past 20 years, with no tendency to stabilization [1, 2]. During the research for an adequate analysis of the results of treatment by the technique under consideration there were formed two groups of patients. The first investigated group included 221 patients, in whom 168 patients were diagnosed HER/2-neu positive tumors in immunohistochemical conclusion and 53 patients had basal-like biological subtype of the. The control group included 64 patients of whom 45 were identified to have HER/2-neu positive and 19 basal-like subtypes of breast cancer.

The control group included 58 patients, among which HER/2-neu positive subtype was found in 45 persons and basal like subtype – in 13 persons. The average life duration of patients in test group was 3,43+0,18 years, while in control group - 1,8+0,4 years that significantly exceeds the statistical data by national and foreign authors. The indices for total 3 years survival rate of patients in test group were 59,9+4,5% and 5 years survival rate - 43,1+5,5 months.

In the control group indicators of cumulative 3- and 5-year survival rates were significantly lower - 37.8% ± 6.6 and 25.2 ± 7.0%months, respectively

The indices for total 3 years and 5 years survival rate of patients in control group were significantly lower - 58,0+6,3% and 17,9+8,4% months, accordingly.


Keywords


locally-advanced breast cancer, complex treatment

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References


Cancer in Ukraine, 2010-2011. Zahvoryvanist, smertnist, pokozniki diialnosti oncologichnoi slyzbi / Pid redakcieu S.O. Shalimova // Buleten nacionalnogo cancer-reestr Ukraine. – Kiev, 2012. – № 13. – 51 p.

Siedakov І.E. Morphologichni kriterii diagnostiki, ocenka efektivnosti I prognoz pri combinovanomy likyvanni miscevo-poshirenogo pervinno- neoperabelnogo raky molochnoi zalozi / Siedakov І.E.// Ukr. med. almanach. – 2004. – Т. 7, № 3. – С. 133 – 137.

Siedakov І.E. Selektivna vnutrishn’oarterialna polihimioterapiya v kompleksnomu likuvanni pervinno-neoperabelnogoraku molochnoi zalozi: avtoref. dis. na zdobuttya nauk. stupenya d.меd.n.: spec. 14.01.07 „оnkologiya” / І.E. Siedakov– Doneck, 2004. – 42 s.

Hortobagyi G.N., Kaufmann M., Goldhirsch A. et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol 2006; 24:1940-9.

Haagensen C., Stout A. Carcinoma of the breast: criteria of operability. Ann. Surg., 1943, 118, 1032–1052.

Kuerer H. M., Schwartz G.F., Lange A.K., Topham A.K. Breast conservation following induction chemotherapy for locally advanced carcinoma of the breast (stages IIB and III). A surgical perspective. Surg. Oncol. Clin. N. Am. 1995, 4,4, 657–669.

Semiglazov V.F., Semiglazov V.V., Klecel А.Е. Neinvazivnie I invazivnie opyholi molochnoi zelezi. – St. Petersburg, 2006. – 350 с.

Fornasiero A., Ghiotto C., Daniele O., Favaretto A.G., D'Amanzo P., Ziade A. Neoadjuvant moderately high-dose chemotherapy with rh-G-CSF in locally advanced breast carcinoma // Tumori. -2001. -Vol. 87, N 4. P. 223-228.

Therasse P. et al. (2003). Taghian A.G., Jeong J.H., Mamounas E.P. et al. Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel project randomized clinical trials // J. Clin. Oncol. – 2006. – 24(24). – 3927-3932.

Fourquet A., Campana F., Scholl S. et al. Primary chemotherapy or primary radiotherapy: a possibility to preserve the breast in large tumors // International Congress of Radiation Oncology 1993. June 21-25. Kyoto, 1993. -P. 112.

Haagensen С., Stout A.P. Carcinoma of the breast. I Results of treatment // Ann. Surg.- 1942.- Vol.116. -P. 801 - 815.

Sravnitelnaia ocenka dvyh rezimov vvedenia protivoopyholevih preparatov po sheme СМF pri dessiminirovanom rake molochnoi zelezi / D.B. Korman, V.А. Snimshikov, L.B. Dobroskok //Soviet medicine. – 1991. – № 3. – С. 14 – 15




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