Association of gene polymorphisms of interleukin-10 (IL-10) with recurrent miscarriage (RM) after fertilization in vitro (IVF)

K. P. Golovatyuk


The objective: to study genotype frequencies and allelic variants of gene IL-10-1082G>A (rs1800896), depending on the reproductive status and evaluation association with RM after IVF among the residents of Odessa region of Ukraine. Under supervision there were 240 patients of the main group with the RM after IVF and 100 apparently healthy fertile women in the control group K with a history of at least one term delivery and lack of spontaneous abortion episodes. SNPs typing of the genes for immune response in was used the polymerase chain reaction with the melting reaction products in the presence of "adjacent" oligonucleotides. It has been established that the carriers of AA genotype of the gene IL-10-1082G>A, which have been women-residents of Odessa region of Ukraine, had a high probability of occurrence of  RM during pregnancy after IVF (OR 2,56; 95% CI 1,51 - 4,35). Typing of SNPs of the immune response gene IL-10 (rs1800896) can be used as a method of early diagnosis and pregravid prediction of reproductive losses in women with RM after IVF.


infertility, in vitro fertilization, recurrent miscarriage, cytokines, interleukin-10, gene polymorphism, inheritance.

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Rudakova EB, Esipovich TV. Optimization of the tactics of managing pregnancy after IVF and PE, complicated by the threat of interruption. Reproductive medicine. 2014. Access mode: 39-optimizaciya-taktiki-vedeniya-beremennosti-posle-eko-i-pe-oslozhnennoy-ugrozoy-preryvaniya.html.

Ghazaey S, Keify F, Mirzaei F. et al. Chromosomal analysis of couples with repeated spontaneous abortions in northeastern Іran. Int J Fertil Steril. 2015; 9(1): 47-54.

Qaddourah RH, Magdoud K, Saldanha FL et al. IL-10 gene promoter and intron polymorphisms and changes in IL-10 secretion in women with idiopathic recurrent miscarriage. Hum Reprod. 2014; 29(5): 1025-34.

Mashkina EV, Kovalenko KA, Miktadova AV et al. Analysis of IL-10 gene expression in decidual and chorionic tissues during miscarriage. Modern problems of science and education. 2013; 5.

Parveen F, Shukla A, Agarwal S. Cytokine gene polymorphisms in northern Indian women with recurrent miscarriages. Fertil Steril. 2013: 99; 433-440.

Vidyadhari M, Sujatha M, Krupa P et al. A functional polymorphism in the promoter region of interleukin-10 gene increases the risk for spontaneous abortions – a triad study. J Assist Reprod Genet. 2015; 32(7): 1129–1134.

Babbage SJ, Arkwright PD, Vince GS et al. Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss. J Reprod Immunol. 2001; 1: 21–7.

Medica I, Ostojic S, Pereza N. et al. Association between genetic polymorphisms in cytokine genes and recurrent miscarriage – a meta-analysis. Reprod Bio Med Online. 2009; 19: 406–14.

Bohiltea CL, Radoi VE. Interleukin-6 and interleukin-10 gene polymorphisms and recurrent pregnancy loss in Romanian population. Iran J Reprod Med. 2014; 12: 617–622.

Karhukorpi J, Leitinen T, Karttunen R, Tiilikainen AS. The functionally important IL-10 promoter polymorphism (-1082G A) is not a major genetic regulator in recurrent spontaneous abortions. Mol Hum Reprod. 2001; 17: 201-203.

Alkhuriji AF, Alhimaidi AR, Babay ZA, Wary AS. The relationship between cytokine gene polymorphism and unexplained recurrent spontaneous abortion in Saudi females. Saudi Med J. 2013; 34: 484–489.

Bahadori M, Saeed Zarei S, Zarnani AH et aI. IL-6, IL-10 and IL-17 gene polymorphisms in Iranian women with recurrent miscarriage. Iran J Immunol. 2014; 11: 97–104.



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