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Role of polymorphisms TNF.- alpha gene in the development of recurrent miscarriage after in vitro fertilization in the residentS of Odessa region of Ukraine
Abstract
Golovatyuk K. P. Role of polymorphisms TNF.- alpha gene in the development of recurrent miscarriage after in vitro fertilization in the residentS of Odessa region of Ukraine. Journal of Education, Health and Sport. 2017;7(1):323 - 332. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.265805
http://ojs.ukw.edu.pl/index.php/johs/article/view/4218
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016).
754 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.01.2017. Revised 16.01.2017. Accepted: 24.01.2017.
UDK 618.177-089.888.11:618.39-0796:575.162
ROLE OF POLYMORPHISMS TNF- alpha GENE IN THE DEVELOPMENT OF recurrent miscarriage after in vitro fertilization in THE residentS of Odessa region of Ukraine
K. P. Golovatyuk
Odessa National medical University, Ukraine;
nosenko.olena@gmail.com; info@gameta.od.ua
Summary
The frequency of genotypes and allelic variants of the TNF-α gene (-238 G> A, -308 G> A, -1031 T > C), depending on the reproductive status and evaluation of its association with recurrent miscarriage (RM) in cycles in vitro fertilization (IVF) has been studied. The residents of the Odessaregion of Ukrainehave been under examination. It has been revealed that typing of SNPs of genes of the immune response TNF-α (rs1799964) and TNF-α (rs1800629) may be used as an early diagnostic method and pregravida prediction of reproductive losses in infertile women with RM after IVF. Genotypes AA -308G> A, (GA + AA) -308G> A and TC-1031C, (TC + CC) -1031C TNF-α gene were statistically significant associated with an increased risk of RM after IVF.
Key words: recurrent miscarriage, in vitro fertilization, tumor necrosis factor-α r, inheritance, polymorphism, genotype, polymerase chain reaction.
Keywords
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Сидельникова В.М. Подготовка и ведение беременности у женщин с привычным невынашиванием: метод. пособия и клин. протоколы / В. М. Сидельникова. – 3-е изд. – М. : МЕДпресс-информ, 2013. – 224 с. : ил. ISBN 978-5-98322-928-0 [ Sidelnikova V. M. Preparation and prenatal care in the women with recurrent miscarriage: study guide and protocols.- 3rd ed.- Moscow: MEDpress-inform, 2013.- 224 p. (Rus.)].
Association of CTLA-4 and TNF-α polymorphism with recurrent miscarriage among North Indian women / Gupta R., Prakash S., Parveen F., Agrawal S. // Cytokine. – 2012. – Vol. 60. – P. 456–462.
Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women / Kamali-Sarvestani E, Zolghadri J, Gharesi-Fard B, Sarvari J. // J. Reprod. Immunol. – 2005. – Vol. 65, N 2. – P. 171–178.
Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause / Prigoshin N., Tambutti M., Larriba J. [et al.] // Am. J. Reprod. Immunol. –2004. – Vol. 52, N 1. – P. 36–41.
Fortunato S.J. IL-1 β is a better inducer of apoptosis in human fetal membranes than IL-6 / Fortunato S.J., Menon R. // Placenta. – 2003. – Vol. 24, N 10. – P. 922–928.
Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction / Ozaki K., Ohnishi Y., Iida A. [et al.] // Nat. Genet. – 2002. – Vol. 32, N 4. – P. 650–654.
Hehlgans T. The intriguing biology of the tumour necrosisfactor/tumour necrosis factor receptor superfamily: players, rulesand the games / T. Hehlgans, K. Pfeffer // Immunology. ¬– 2005. – Vol. 115, N 1–20.
HLA and tumor necrosis factor beta gene polymorphisms in Okinawa lung cancer patients: comparative study with mainland Japan lung cancer patients / Hagihara M., Shimura T., Sato K. [et al.] // Hum. Immunol. – 1995. – Vol. 43, N 2. – P. 95–100.
Kuar A. Recurrent pregnancy loss: TNF-α and IL-10 polymorphisms / A. Kuar // J. Hum. Reprod. – 2011. – Vol. 4. – P. 91–94.
Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production / Messer G., Spengler U., Jung M.C. [et al.] // J. Exp .Med. – 1991. – Vol. 173, N 1. – P. 209–219.
Polymorphism of the 5’-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese / Higuchi T., Seki N., Kamizono S. [et al.] // Tissue Antigens. – 1998. – Vol. 51, N 6. – P. 605–612.
Preterm birth and single nucleotide polymorphisms in cytokine genes / Q. Zhu, J. Sun, Y.Chen / Transl. Pediatr. – 2014. – Vol. 3, N 2. – P.120–134.
Recurrent miscarriage and variant alleles of mannose binding lectin, tumour necrosis factor and lymphotoxin-a genes / Baxter N., Sumiya M., Cheng S. [et al.] // Clin. Exp. Immunol. – 2001. – Vol. 126, N 3. – P. 529–534.
Relationship between expression of COX-2, TNF-α, IL-6 and autoimmune-type recurrent miscarriage / Hua F., Li C.H., Wang H., Xu H.G. // Asian. Pac. J. Trop. Med. – 2013. – Vol. 6, N 990–994.
Rull K. Genetics of recurrent miscarriage: challenges, current knowledge, future directions / Rull K., Nagirnaja L., Laan M. // Front. Genet. – 2012. – N 3. –P. 34.
Th1 cytokines and the prothrombinase fgl2 in stress-triggered and inflammatory abortion / Knackstedt M.K., Zenclussen A.C., Hertwig K. [et al.] // American Journal of Reproductive Immunology. – 2003. – Vol. 49, N 4. – P. 210–220.
The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome / Yun J.-H., Choi J.-W., Lee K.-J. [et al.] //Reprod Biol Endocrinol. – 2011. – Vol. 9. – P. 131.
The relationship between cytokine gene polymorphism and unexplained recurrent spontaneous abortion in Saudi females / Alkhuriji A.F., Alhimaidi A.R., Babay Z.A., Wary A.S. // Saudi Medical Journal. – 2013. – Vol. 34. –P. 484–489.
Tumor necrosis factor-alpha gene (TNF-alpha)-1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese / Soga Y., Nishimura F., Ohyama H. et al. // J. Clin. Periodontol. –2003. – Vol. 30, N 6. – P. 524–531.
Tumor necrosis factor-alpha polymorphisms in women with idiopathic recurrent miscarriage / Finan R.R., Al-Irhayim Z., Mustafa F.E. [et al.] // J. Reprod. Immunol. – 2010. – Vol. 84. – P. 186–192.
Tumor Necrosis Factor-α Gene Polymorphisms in Korean Patients With Recurrent Spontaneous Abortion / Lee B. E., Jeon Y. J., Shin J. E. [et al.] // Reprod Sci. – 2013. – Vol. 20, N 4. – P. 408–413.
DOI: http://dx.doi.org/10.5281/zenodo.265805
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