Сравнительная характеристика показателей активности воспалительного процесса при пиелонефрите на фоне пузырно-мочеточникового рефлюкса у детей раннего возраста = The comparative characteristic of indicators of activity of inflammatory process with pyelonephritis on the background of vesicoureteral reflux in children of early age

N. I. Tokarchuk, I. V. Odarchuk

Abstract


Tokarchuk N. I., Odarchuk I. V. Сравнительная характеристика показателей активности воспалительного процесса при пиелонефрите на фоне пузырно-мочеточникового рефлюкса у детей раннего возраста = The comparative characteristic of indicators of activity of inflammatory process with pyelonephritis on the background of vesicoureteral reflux in children of early age. Journal of Education, Health and Sport. 2016;6(8):734-746. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.62073

http://ojs.ukw.edu.pl/index.php/johs/article/view/3849

 

 

 

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.08.2016. Revised 25.08.2016. Accepted: 28.08.2016.

 

 

УДК: 616.61-002.3:616.62-008.22-053.3

 

Сравнительная характеристика показателей активности воспалительного процесса при пиелонефрите на фоне пузырно-мочеточникового рефлюкса у детей раннего возраста

 

Н. И. Токарчук, И. В. Одарчук

 

Винницкий национальный медицинский университет им. Н. И. Пирогова,

г. Винница, Украина

 

Резюме
В работе представлен анализ лабораторных показателей активности воспалительного процесса при пиелонефрите у детей раннего возраста. Определено повышение плазменной концентрации прокальцитонина и моноцитарного хемоаттрактантного протеина 1 у детей с пиелонефритом. Установлена высокая чувствительность и специфичность данных показателей при пиелонефрите у детей раннего возраста.

 

Ключевые слова: пиелонефрит, дети раннего возраста, прокальцитонин, моноцитарный хемоаттрактантний протеин 1.

 

 

 

 

 

 

The comparative characteristic of indicators of activity of inflammatory process with pyelonephritis on the background of vesicoureteral reflux in children of early age

 

N. I. Tokarchuk, I. V. Odarchuk

 

Vinnitsa National Pirogov Memorial Medical University, Vinnitsa, Ukraine

 

Abstract

The paper presents the analysis of laboratory indices of inflammatory process activity in case of pyelonephritis in children of early age. Determined increased plasma concentration of procalcitonin and monocyte chemoattractant protein1 inchildren with pyelonephritis. Plasma concentration of procalcitonin and monocyte chemoattractant protein 1 is higher in children with pyelonephritis on the background of vesicoureteral reflux than in children with primary pyelonephritis. It is shown that the levels of procalcitonin and monocyte chemoattractant protein 1 tended to increase with age of the examined children. The highest indicators were recorded at the age of 2 years 3 years than patients aged 1 month-1 year, 1 year-2 years and in children of the control group.

Was determined increased production of markers of inflammation predominantly in girls than in boys, who were ill with pyelonephritis. This is due to the anatomical structure of the urinary system and greater probability of infection of urine and maintaining the inflammatory process in girls. Along with the increase in the degree of inflammatory activity in the kidneys increased levels of procalcitonin and monocyte chemoattractant protein 1.

We have established high sensitivity and specificity of these indicators in pyelonephritis in children of early age.

 

Key words: pyelonephritis, young children, procalcitonin, monocyte chemoattractant protein 1.


Keywords


пиелонефрит, дети раннего возраста, прокальцитонин, моноцитарный хемоаттрактантний протеин 1, pyelonephritis, young children, procalcitonin, monocyte chemoattractant protein 1.

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References


Литература:

Борисова Т.П. Инфекции мочевой системы у детей. Пиелонефрит. Диагностические подходы и лечебная тактика на уровне первичной медико-санитарной помощи / Т. П. Борисова // Здоровье ребенка. – 2012.- №4 . – С. 18-29.

Дащенко О. О. Клініко-лабораторна характеристика пієлонефриту у дітей різних вікових груп / О. О. Дащенко, І. В. Багдасарова, О. В. Лавренчук // Педіатрія, акушерство та гінекологія. – 2009. – № 3. – С. 42-46.

Кривоносова Е.П. Характер адаптационных реакций организма и физико-химические свойства мочи при пиелонефрите у детей / Е. П. Кривоносова, Г. М. Летифов // Педиатрия. Журнал им.Г.Н.Сперанского. - 2010. - № 6. - С. 159-160

Мигаль Л. Я. Ензимологічні можливості діагностики ступеня активності запального процесу у дітей, хворих на пієлонефрит / Л. Я. Мигаль // Лабораторна діагностика. - 2009. - № 1. - С. 19-23

Триндюк Ю.С. Особливості фосфоліпідного спектра сироватки крові в дітей, хворих на пієлонефрит / Ю. С. Триндюк // Здоровье ребенка. - 2011. - № 4. - С. 45-47.

Триндюк Ю.С. Деякі аспекти діагностики пієлонефриту у дітей / Ю. С. Триндюк // Здоровье ребенка. - 2011. - № 5. - С. 36-38.

Procalcitonin increase after endotoxin infection in normal subjects. / P. Dandona , D. Nix, M. F. Wilson [et al.] // J Clin. Endocrinol. Metab. -2009.- Vol. 79. - P. 605– 608.

Gervaix A. Usefulness of procalcitonin and C-reactive protein rapid tests for the management of children with urinary tract infection / А. Gervaix , А. Galletto-Lacour , Т. Gueron // Pediatr. Infect. Dis. J. - 2010. - Vol. 20. - P. 507– 511.

Guidelineson Paediatric Urology/ S. Tekgül, H. Riedmiller, H. S. Dogan, E. Gerharz, P. Hoebeke, R. Kocvara, Chr. Radmayr, R. Stein: European Society for Paediatric Urology/ European Association of Urology, 2012.

Colorand Power Doppler Sonography Versus DMSA Scintigraphyin Acute Pyelonephritis an din Prediction of Renal Scarring./ А. Hitzel, A. Liard, P. Vira [et al.] // The Jornal of Nuclean Medicine.- 2011. – Vol. 7. - P. 15 – 19.

Leroy S. Association of Procalcitonin With Acute Pyelonephritis and Renal Scarsin Pediatric/ S. Leroy, A. Fernandez-Lopez, R. Nikfar // UTI Pediatrics. - 2013. – Vol. 131. - P. 870-879.

Polito C. Permanent renal parenchymal defects after febrile UTI are closely associated with vesicoureteric reflux / C. Polito, P. F. Rambaldi, G. Signoriello // Pediatr Nephrol. - 2009. - Vol. 21. - P. 51– 56.

Prat C. Elevated serum procalcitonin values correlate with renal scarring in children with urinary tract infection / C. Prat, J. Dominguez, C. Rodrigo // Pediatr Infect Dis J. - 2008.- Vol. 22. - P. 438– 442.

Satish L. D. Monocyte Chemoattractant Protein-1 (MCP-1) : An Overview. J. / L. D. Satish [et al.] // J. of interferon & cytokine research. - 2009. - Vol. 29. - N 6. - P. 3313-326.

References

Borisova T.P. (2012) Infektsii mochevoy sistemy u detey. Pielonefrit. Diagnosticheskie podkhody i lechebnaya taktika na urovne pervichnoy mediko-sanitarnoy pomoshchi [Urinary tract infection in children. Pyelonephritis. Diagnostic approach and treatment strategy in primary health care]. Zdorove rebenka - The health of the child, 4 , 18-29 [in Russian].

Dashchenko O. O., Bagdasarova І. V., & Lavrenchuk O. V. (2009) Klіnіko-laboratorna kharakteristika pієlonefritu u dіtey rіznikh vіkovikh grup [Clinical and laboratory characteristics of pyelonephritis in children of different age groups]. Pedіatrіya, akusherstvo ta gіnekologіya - Pediatrics, obstetrics and gynecology, 3, 42-46 [in Russian].

Krivonosova Ye.P., & Letifov G. M. (2010) Kharakter adaptatsionnykh reaktsiy organizma i fiziko-khimicheskie svoystva mochi pri pielonefrite u detey [The nature of adaptive reactions of the organism and the physico-chemical properties of urine in pyelonephritis in children]. Pediatriya. Zhurnal im.G.N.Speranskogo - Pediatrics. Journal named after G. N. Speransky, 6, 159-160 [in Russian].

Myhal L. Ya. (2009) Enzymolohichni mozhlyvosti diahnostyky stupenia aktyvnosti zapalnoho protsesu u ditei, khvorykh na piielonefryt [Enzymologic diagnostics of the degree of activity of inflammatory process in children with pyelonephritis]. Laboratorna diahnostyka - Laboratory diagnosis, 1, 19-23 [in Ukraine].

Tryndiuk Yu. S. (2011) Osoblyvosti fosfolipidnoho spektra syrovatky krovi v ditei, khvorykh na piielonefryt [Peculiarities of the phospholipid spectrum of blood serum in children suffering from pyelonephritis]. Zdorove rebenka - The health of the child, 4, 45-47 [in Ukraine].

Tryndiuk Yu.S. (2011) Deiaki aspekty diahnostyky piielonefrytu u ditei [Some aspects of diagnosis of pyelonephritis in children]. Zdorove rebenka - The health of the child, 5, 36-38 [in Ukraine].

Procalcitonin increase after endotoxin infection in normal subjects. / P. Dandona , D. Nix, M. F. Wilson [et al.] // J Clin. Endocrinol. Metab. -2009.- Vol. 79. - P. 605– 608.

Gervaix A. Usefulness of procalcitonin and C-reactive protein rapid tests for the management of children with urinary tract infection / А. Gervaix , А. Galletto-Lacour , Т. Gueron // Pediatr. Infect. Dis. J. - 2010. - Vol. 20. - P. 507– 511.

Guidelineson Paediatric Urology/ S. Tekgül, H. Riedmiller, H. S. Dogan, E. Gerharz, P. Hoebeke, R. Kocvara, Chr. Radmayr, R. Stein: European Society for Paediatric Urology/ European Association of Urology, 2012.

Colorand Power Doppler Sonography Versus DMSA Scintigraphyin Acute Pyelonephritis an din Prediction of Renal Scarring./ А. Hitzel, A. Liard, P. Vira [et al.] // The Jornal of Nuclean Medicine.- 2011. – Vol. 7. - P. 15 – 19.

Leroy S. Association of Procalcitonin With Acute Pyelonephritis and Renal Scarsin Pediatric/ S. Leroy, A. Fernandez-Lopez, R. Nikfar // UTI Pediatrics. - 2013. – Vol. 131. - P. 870-879.

Polito C. Permanent renal parenchymal defects after febrile UTI are closely associated with vesicoureteric reflux / C. Polito, P. F. Rambaldi, G. Signoriello // Pediatr Nephrol. - 2009. - Vol. 21. - P. 51– 56.

Prat C. Elevated serum procalcitonin values correlate with renal scarring in children with urinary tract infection / C. Prat, J. Dominguez, C. Rodrigo // Pediatr Infect Dis J. - 2008.- Vol. 22. - P. 438– 442.

Satish L. D. Monocyte Chemoattractant Protein-1 (MCP-1) : An Overview. J. / L. D. Satish [et al.] // J. of interferon & cytokine research. - 2009. - Vol. 29. - N 6. - P. 3313-326.




DOI: http://dx.doi.org/10.5281/zenodo.62073

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