Динаміка морфофункціональних зрушень підшлункової залози та рівень цитокинів у потомства щурів внаслідок дії хронічного стресу = The dynamics of the morphofunctional changes of the offspring-rats’ pancreases and level of cytokinins resulting from an action of the chronic stress

O. Nikolayeva, E. Pavlova, V. Sirenko, M. Kovaltsova, I. Sulhdost

Abstract


Nikolayeva O., Pavlova E., Sirenko V., Kovaltsova M., Sulhdost I. Динаміка морфофункціональних зрушень підшлункової залози та рівень цитокинів у потомства щурів внаслідок дії хронічного стресу = The dynamics of the morphofunctional changes of the offspring-rats pancreases and level of cytokinins resulting from an action of the chronic stress. Journal of Education, Health and Sport. 2016;6(6):279-290. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55416

http://ojs.ukw.edu.pl/index.php/johs/article/view/3578

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).

755 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author (s) 2016;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.05.2016. Revised 25.05.2016. Accepted: 10.06.2016.

 

УДК 616.37–091.8–092.9:613.24/.25:613.65:612.015.11

 

ДИНАМІКА МОРФОФУНКЦІОНАЛЬНИХ ЗРУШЕНЬ ПІДШЛУНКОВОЇ ЗАЛОЗИ ТА РІВЕНЬ ЦИТОКИНІВ У ПОТОМСТВА ЩУРІВ ВНАСЛІДОК ДІЇ ХРОНІЧНОГО СТРЕСУ

 

О. В. Ніколаєва, О. О. Павлова, В. А. Сіренко, М. В. Ковальцова, І. О. Сулхдост

 

Харківський національний медичний університет. Харків. Україна

 

The Dynamics Of The Morphofunctional Changes Of The Offspring-Rats Pancreases and Level Of Cytokinins Resulting From An Action Of The Chronic Stress

 

O. Nikolayeva, E. Pavlova, V. Sirenko, M. Kovaltsova, I. Sulhdost

 

Kharkiv National Medical University, Kharkov, Ukraine

 

Introduction. The pathology of the pancreas caused by the stress is an actual problem of medicine. The purpose of the study was describe of characteristics morphofunctional state of the pancreas of babe-rats’ and to analyzed pro-inflammatory and anti-inflammatory cytokines balance. Materials and Methods. We studied morphological changes of pancreas of offspring-rats’ using histological, cytochemical, cytomorphometric and biochemical methods. We studied immunological status using biochemical methods. We studied the level of interleukin-12 and interleukin-4 in the blood. The core group of mother-rats was exposed to chronic stress immobilization. The comparison group consisted of animals that led ordinary life. For the rats, the experiment was stopped immediately after the birth of offspring in compliance with the ethical principles. Results. Stress during pregnancy in rats affects the morphology and function of the pancreas in the offspring. Symptoms of morphofunctional disorders are obvious even in the pancreas of newborn rats. There are reduced acini and islets of Langerhans, immaturity parenchymal area, edema, fibrosis, degenerative changes in the nuclei and cytoplasm exocrine and endocrine cells, decrease morphofunctional state of the same part of pancreas cell, violation of geodynamics. Most of them not only saves up until they are two months of age, but has a negative trend of growth severity: reducing the relative amount of parenchymal acini area, number and area of the islets of Langerhans, the number of endocrine cells in them, apiaries lipomatosis stroma. We also noticed simultaneous launch of compensatory-adaptive processes in the endocrine pancreas in the form of hypertrophy of single islets of Langerhans. The rats in all groups are diagnosed as having identical tendencies of cytokines change; significant buildup of pro-inflammatory interleukin-12 and reduction of anti-inflammatory interleukin-4 which indicates predominant involvement in pathogenesis of violation of pancreas cell component of immune system. Conclusions. The results suggest that chronic stress of pregnant rats is a significant risk factor for future chronic pathology of the pancreas rats-offspring.

Keywords: chronic stress immobilization, pancreas, rats, interleukin, experiment.

 

ДИНАМИКА МОРФОФУНКЦИОНАЛЬНЫХ НАРУШЕНИЙ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ И УРОВЕНЬ ЦИТОКИНОВ У ПОТОМСТВА КРЫС ВСЛЕДСТВИЕ ДЕЙСТВИЯ ХРОНИЧЕСКОГО СТРЕССА

 

О. В. Николаева, Е. А. Павлова, В. А. Сиренко, М. В. Ковальцова, И. А. Сулхдост

 

Харьковский национальный медицинский университет, Харьков, Украина

 

Проведено морфологическое и биохимическое исследование влияния хронического стресса матери на морфофункциональные особенности поджелудочной железы новорожденного, одномесячного и двухмесячного потомства. Обнаружено, что пренатальный стресс приводит к морфофункциональной перестройке поджелудочной железы крысиного потомства, с развитием стойких и прогрессирующих в динамике деструктивных изменений в ациноцитах и эндокриноцитах, к снижению морфофункциональной активности части клеточных элементов, к развитию гемодинамических нарушений у части животных. Выяснено, что у разновозрастного крысиного потомства наблюдается системный гуморальный ответ в виде дисбаланса цитокинов с преобладанием  маркерного цитокина Th1-лимфоцитов (интерлейкина-12), что свидетельствует о вовлечении в патогенезе повреждения поджелудочной железы клеточной цепи иммунитета. Установлено, что цитокиновый дисбаланс негативно влияет на внутриклеточный метаболизм панкреацитов, их экзокринную и эндокринную секреторную активность, и, вероятно, может еще больше усиливать повреждения поджелудочной железы у экспериментальных животных.

          Ключевые слова: ациноциты, эндокриноциты, иммобилизация, интерлейкины, крысята, эксперимент.


Keywords


ациноциты, эндокриноциты, иммобилизация, интерлейкины, крысята, эксперимент, chronic stress immobilization, pancreas, rats, interleukin, experiment.

References


Бібліографічні посилання

Riis J.L., Granger D.A., Minkovitz C.S., Bandeen-Roche K., DiPietro J.A., Johnson S.B.: Maternal distress and child neuroendocrine and immune regulation. Soc. Sci. Med. 2016 Feb;151:206-14. doi: 10.1016/j.socscimed.2015.12.043. Epub 2016 Jan 5.

Nielsen J.H., Haase T.N., Jaksch C., Nalla A., Søstrup B., Nalla A.A., Larsen L., Rasmussen M., Dalgaard L.T., Gaarn L.W., Thams P., Kofod H., Billestrup N.: Impact of fetal and neonatal environment on beta cell function and development of diabetes. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1109-22. doi: 10.1111/aogs.12504. Epub 2014 Oct 10.

Sun S., Tian L., Qiu H., Chan K.P., Tsang H., Tang R., Lee R.S., Thach T.Q., Wong C.M.: The influence of pre-existing health conditions on short-term mortality risks of temperature: Evidence from a prospective Chinese elderly cohort in Hong Kong. Environ. Res. 2016 Mar 16;148:7-14. doi: 10.1016/j.envres.2016.03.012.

И. В. Сорокина Морфологические особенности поджелудочной железы мертворожденных от ВИЧ-инфицированных матерей / И. В. Сорокина, С. А. Шерстюк // Вісник проблем біології і медицини – 2011 – Вип. 2, Т. 1 стр. 199-202

Chavey A., Ah Kioon M.D., Bailbé D., Movassat J., Portha B.: Maternal diabetes, programming of beta-cell disorders and intergenerational risk of type 2 diabetes. Diabetes Metab. 2014 Nov;40(5):323-30. doi: 10.1016/j.diabet.2014.02.003. Epub 2014 Jun 16.

E. Hajj N., Schneider E., Lehnen H., Haaf T.: Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment. Reproduction. 2014 Dec;148(6):R111-20. doi: 10.1530/REP-14-0334. Epub 2014 Sep 3.

Abbasi I.S.: The Role of Neuroticism in the Maintenance of Chronic Baseline Stress Perception and Negative Affect. Span J. Psychol. 2016 Mar 4;19:E9. doi: 10.1017/sjp.2016.7.

Mairesse J., Silletti V., Laloux C., Zuena A.R., Giovine A., Consolazione M., van Camp G., Malagodi M., Gaetani S., Cianci S., Catalani A., Mennuni G., Mazzetta A., van Reeth O., Gabriel C., Mocaër E., Nicoletti F., Morley-Fletcher S., Maccari S. Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats. Int. J. Neuropsychopharmacol. 2013 Mar;16(2):323-38. doi: 10.1017/S1461145711001970. Epub 2012 Feb 6.

Zuena A.R., Mairesse J., Casolini P., Cinque C., Alemà G.S., Morley-Fletcher S., Chiodi V., Spagnoli L.G., Gradini R., Catalani A., Nicoletti F., Maccari S. Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats. PLoS One. 2008 May 14;3(5):e2170. doi: 10.1371/journal.pone.0002170.

Amy E.B. Packard , Sriparna Ghosal, James P. Herman, Stephen C. Woods, Yvonne M. Ulrich-Lai: Chronic variable stress improves glucose tolerance in rats with sucrose-induced prediabetes, Psychoneuroendocrinology, Volume 47, September 2014, Pages 178-188

Ergaz Z., Neeman-Azulay M., Weinstein-Fudim L., Weksler-Zangen S., Shoshani-Dror D., Szyf M., Ornoy A.: Diabetes in the Cohen Rat Intensifies the Fetal Pancreatic Damage Induced by the Diabetogenic High Sucrose Low Copper Diet. Birth Defects Res B Dev Reprod Toxicol. 2016 Feb;107(1):21-31. doi: 10.1002/bdrb.21169. Epub 2016 Jan 7.

Hanafi MY, Saleh MM, Saad MI, Abdelkhalek TM, Kamel MA.: Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Mol Cell Biochem. 2016 Jan;412(1-2):269-80. doi: 10.1007/s11010-015-2633-6.

Brandy A. Wicklow, Elizabeth A.C. Sellers: Maternal health issues and cardio-metabolic outcomes in the offspring: A focus on Indigenous populationsOriginal Research Article, Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 29, Issue 1, January 2015, Pages 43-53

Damasceno D.C., Netto A.O., Iessi I.L., Gallego F.Q., Corvino S.B., Dallaqua B., Sinzato Y.K., Bueno A., Calderon I.M., Rudge M.V.: Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes. Biomed Res Int. 2014; 2014:819065. doi: 10.1155/2014/819065. Epub 2014 May 27.

Liang B., Zheng X., Xia W.W., Ding Y., Zhang W., Zhou X.: Establishment of chronic constraint stress animal model and its application in the study of hyperglycemia, Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 May; 44(3):470-5.

Lesage J., Del-Favero F., Leonhardt M., Louvart H., Maccari S., Vieau D., Darnaudery M.: Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J. Endocrinol. 2004 May;181(2):291-6.

Wang J.Y. Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice / J.Y. Wang, C. Zhu, T.W. Qian, H. Guo // Exp. Ther. Med. – 2015. – № 9 (1). – Р. 43-48.

Uslukaya O., Turkoglu A., Yazgan U.C., Kaplan I., Ibiloglu I., Kapan M., Gumus M.: The effects of roflumilast on the pancreas and remote organs in a cerulein-induced experimental acute pancreatitis model in rats. Surg Today. 2016 Mar 16.

Binker M.G., Binker-Cosen A.A., Richards D., Gaisano H.Y., de Cosen R.H., Cosen-Binker L.I.: Chronic stress sensitizes rats to pancreatitis induced by cerulein: role of TNF-α. World J Gastroenterol. 2010 Nov 28;16(44):5565-81.

Binker M.G., Cosen-Binker L.I.: Acute pancreatitis: the stress factor.World J. Gastroenterol. 2014 May 21;20(19):5801-7. doi: 10.3748/wjg.v20.i19.5801.

Пат. 82414 UA,A61D 99/00, G09В 23/28 (2006.01) Спосіб моделювання хронічного іммобілізаційного стрессу / Ніколаєва О.В., Ковальова М.В., Євтушенко Т.Г. (UA); заявник Харківський національний медичний університет (UA). - № u 2013 03868, заявл. 29.03.2013; опубл. 25.07.2013. Бюл. № 14. – 4 с.

Меркулов Г.А. Курс патологогистологической техники. – М.: Медицина, 1961. – 339 с.; Микроскопическая техника: Руководство / Под ред. Д.С.Саркисова, Ю.Л.Перова. – М.: Медицина, 1996. – 544 с.

Гланц, С. Медико-біологічна статистика / С. Гланц; з англ. С. Гланц. – М.: Практика, 1998. – 459 с.

Tsuji M., Koriyama C., Yamamoto M., Anan A., Shibata E., Kawamoto T. The association between maternal psychological stress and inflammatory cytokines in allergic young children. PeerJ. 2016 Jan 18;4:e1585. doi: 10.7717/peerj.1585. eCollection 2016.

do Prado C.H., Narahari T., Holland F.H., Lee H.N., Murthy S.K., Brenhouse H.C. Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress. Dev. Psychobiol. 2015 Dec 21. doi: 10.1002/dev.21390.

References

Riis J.L., Granger D.A., Minkovitz C.S., Bandeen-Roche K., DiPietro J.A., Johnson S.B.: Maternal distress and child neuroendocrine and immune regulation. Soc. Sci. Med. 2016 Feb;151:206-14. doi: 10.1016/j.socscimed.2015.12.043. Epub 2016 Jan 5.

Nielsen J.H., Haase T.N., Jaksch C., Nalla A., Søstrup B., Nalla A.A., Larsen L., Rasmussen M., Dalgaard L.T., Gaarn L.W., Thams P., Kofod H., Billestrup N.: Impact of fetal and neonatal environment on beta cell function and development of diabetes. Acta Obstet Gynecol Scand. 2014 Nov;93(11):1109-22. doi: 10.1111/aogs.12504. Epub 2014 Oct 10.

Sun S., Tian L., Qiu H., Chan K.P., Tsang H., Tang R., Lee R.S., Thach T.Q., Wong C.M.: The influence of pre-existing health conditions on short-term mortality risks of temperature: Evidence from a prospective Chinese elderly cohort in Hong Kong. Environ. Res. 2016 Mar 16;148:7-14. doi: 10.1016/j.envres.2016.03.012.

I.V. Sorokina, S. A. SHerstyuk Morfologicheskie osobennosti podzheludochnoj zhelezy mertvorozhdennyh ot VICH-inficirovannyh materej Vіsnik problem bіologії і medicini, 2011, Vip. 2, T. 1 str. 199-202 [in Ukrainian].

Chavey A., Ah Kioon M.D., Bailbé D., Movassat J., Portha B.: Maternal diabetes, programming of beta-cell disorders and intergenerational risk of type 2 diabetes. Diabetes Metab. 2014 Nov;40(5):323-30. doi: 10.1016/j.diabet.2014.02.003. Epub 2014 Jun 16.

E. Hajj N., Schneider E., Lehnen H., Haaf T.: Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment. Reproduction. 2014 Dec;148(6):R111-20. doi: 10.1530/REP-14-0334. Epub 2014 Sep 3.

Abbasi I.S.: The Role of Neuroticism in the Maintenance of Chronic Baseline Stress Perception and Negative Affect. Span J. Psychol. 2016 Mar 4;19:E9. doi: 10.1017/sjp.2016.7.

Mairesse J., Silletti V., Laloux C., Zuena A.R., Giovine A., Consolazione M., van Camp G., Malagodi M., Gaetani S., Cianci S., Catalani A., Mennuni G., Mazzetta A., van Reeth O., Gabriel C., Mocaër E., Nicoletti F., Morley-Fletcher S., Maccari S. Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats. Int. J. Neuropsychopharmacol. 2013 Mar;16(2):323-38. doi: 10.1017/S1461145711001970. Epub 2012 Feb 6.

Zuena A.R., Mairesse J., Casolini P., Cinque C., Alemà G.S., Morley-Fletcher S., Chiodi V., Spagnoli L.G., Gradini R., Catalani A., Nicoletti F., Maccari S. Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats. PLoS One. 2008 May 14;3(5):e2170. doi: 10.1371/journal.pone.0002170.

Amy E.B. Packard , Sriparna Ghosal, James P. Herman, Stephen C. Woods, Yvonne M. Ulrich-Lai: Chronic variable stress improves glucose tolerance in rats with sucrose-induced prediabetes, Psychoneuroendocrinology, Volume 47, September 2014, Pages 178-188

Ergaz Z., Neeman-Azulay M., Weinstein-Fudim L., Weksler-Zangen S., Shoshani-Dror D., Szyf M., Ornoy A.: Diabetes in the Cohen Rat Intensifies the Fetal Pancreatic Damage Induced by the Diabetogenic High Sucrose Low Copper Diet. Birth Defects Res B Dev Reprod Toxicol. 2016 Feb;107(1):21-31. doi: 10.1002/bdrb.21169. Epub 2016 Jan 7.

Hanafi MY, Saleh MM, Saad MI, Abdelkhalek TM, Kamel MA.: Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Mol Cell Biochem. 2016 Jan;412(1-2):269-80. doi: 10.1007/s11010-015-2633-6.

Brandy A. Wicklow, Elizabeth A.C. Sellers: Maternal health issues and cardio-metabolic outcomes in the offspring: A focus on Indigenous populationsOriginal Research Article, Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 29, Issue 1, January 2015, Pages 43-53

Damasceno D.C., Netto A.O., Iessi I.L., Gallego F.Q., Corvino S.B., Dallaqua B., Sinzato Y.K., Bueno A., Calderon I.M., Rudge M.V.: Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes. Biomed Res Int. 2014; 2014:819065. doi: 10.1155/2014/819065. Epub 2014 May 27.

Liang B., Zheng X., Xia W.W., Ding Y., Zhang W., Zhou X.: Establishment of chronic constraint stress animal model and its application in the study of hyperglycemia, Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 May; 44(3):470-5.

Lesage J., Del-Favero F., Leonhardt M., Louvart H., Maccari S., Vieau D., Darnaudery M.: Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J. Endocrinol. 2004 May;181(2):291-6.

Wang J.Y. Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice / J.Y. Wang, C. Zhu, T.W. Qian, H. Guo // Exp. Ther. Med. – 2015. – № 9 (1). – Р. 43-48.

Uslukaya O., Turkoglu A., Yazgan U.C., Kaplan I., Ibiloglu I., Kapan M., Gumus M.: The effects of roflumilast on the pancreas and remote organs in a cerulein-induced experimental acute pancreatitis model in rats. Surg Today. 2016 Mar 16.

Binker M.G., Binker-Cosen A.A., Richards D., Gaisano H.Y., de Cosen R.H., Cosen-Binker L.I.: Chronic stress sensitizes rats to pancreatitis induced by cerulein: role of TNF-α. World J Gastroenterol. 2010 Nov 28;16(44):5565-81.

Binker M.G., Cosen-Binker L.I.: Acute pancreatitis: the stress factor.World J. Gastroenterol. 2014 May 21;20(19):5801-7. doi: 10.3748/wjg.v20.i19.5801.

Nikolaeva, O.V., & Kovaltsova, M.V., & Evtyshenko T.G. (2013). Sposib modeluvannj immobilization chronic stress [Sposіb modelyuvannya chronichnogo imobilizacinogo stresy] Pat. 82414 UA,A61D 99/00, G09В 23/28. – Bul., 14, 4 [in Ukrainian].

Merculov, G.A. (1998) Kyrs patologogistologicheskoy texniki [Course of patologogistologicheskoy technology]. Moskov [ in Russian].

Glans, S (1998). Mediko-biologicheskay statistika [Of Biomedical Statistics]. Moskov [ in Russian].

Tsuji M., Koriyama C., Yamamoto M., Anan A., Shibata E., Kawamoto T. The association between maternal psychological stress and inflammatory cytokines in allergic young children. PeerJ. 2016 Jan 18;4:e1585. doi: 10.7717/peerj.1585. eCollection 2016.

do Prado C.H., Narahari T., Holland F.H., Lee H.N., Murthy S.K., Brenhouse H.C. Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress. Dev. Psychobiol. 2015 Dec 21. doi: 10.1002/dev.21390.




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Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)