Мультифакторное моделирование атеросклероза на крысах = Multifactorial modeling of atherosclerosis in rats

I. V. Savitskiy, A. A. Sliusar, I. V. Miastkovskaja

Abstract


Savitskiy I. V., Sliusar A. A., Miastkovskaja I. V. Мультифакторное моделирование атеросклероза на крысах = Multifactorial modeling of atherosclerosis in rats. Journal of Education, Health and Sport. 2016;6(3):233-240. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55402

http://ojs.ukw.edu.pl/index.php/johs/article/view/3577

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).

755 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author (s) 2016;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.03.2016. Revised 20.03.2016. Accepted: 23.03.2016.

 

УДК 616-092.9

 

Мультифакторное моделирование атеросклероза на крысах

 

И. В. Савицкий, А. А. Слюсарь, И. В. Мястковская

 

Одесский национальный медицинский университет, Одесса, Украина

 

Реферат

В статье рассмотрена новая методика экспериментального атеросклероза на крысах линии Wistar, которая берет в своем начале полиэтиологическую теорию развития заболевания. Был проведен эксперимент и  полученные результаты оценивали степень взаимодействия факторов нагрузки, которые заключались в одновременной постановке экспериментального гипотиреоза при помощи Мерказолила, иммуносупрессии Метилпреднизолоном на фоне гепатотоксического действия раствора этилового спирта и классической атерогенной диеты. В работе приведены предварительные данные за две недели, которые достигли границы верхней нормы у одной из групп, а так же значительное достоверное повышение уровня ЛПоНП выше нормы.

Ключевые слова: экспериментальный атеросклероз, патогенез заболевания, сердечно-сосудистая патология.

 

 

 

 

 

 

 

Multifactorial modeling of atherosclerosis in rats

 

I. V. Savitskiy, A. A. Sliusar, I. V. Miastkovskaja

 

Odessa National Medical University, Odessa, Ukraine

 

Summary

The article describes a new method of experimental atherosclerosis in rats of Wistar line, which originates in the theory that disease has a multifactorial ethiology. Experiment and the results can show the interaction of atherogenic  factors, which consisted in the simultaneous staging of experimental hypothyroidism using Mercazolilum, methylprednisolone immunosuppression on the background of hepatotoxic action of ethyl alcohol solution and atherogenic diet. This work shows the preliminary data for two weeks, in which the upper border of biochemical rate was reached in one of the groups, as well as a significant increase in the level of VLDL above normal.

Keywords: experimental atherosclerosis, the pathogenesis of the disease, cardiovascular disease.


Keywords


экспериментальный атеросклероз, патогенез заболевания, сердечно-сосудистая патология, experimental atherosclerosis, the pathogenesis of the disease, cardiovascular disease

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References


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Fluiter K., Van Der Westhuijzen D. R., Van Berkel T. J. 1998, «In vivo regulation of scavenger receptor BI and the selective uptake of high density lipoprotein cholesteryl esters in rat liver parenchymal and Kupffer cells», J. Biol. Chem., V.273, pp. 8434–8438.

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Santillo M., Migliaro A., Mondola P., Laeza C. 1999, «Dietary and hypothyroid hypercholesterolemia induces hepatic apoliprotein E expression in the rat: direct role of cholesterol», FEBS Letters, Vol. 463, pp. 83-86.

Meir C. 2001, «TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind placebo-controlled trial (Base thyroid study)», The Journal of Clinical Endocrinology & metabolism, #86, pp. 104860-104866.

Boucher P., Lin I. 2002, «Platelet – derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low density lipoprotein receptor related protein in carediae», J. Biol. Chem., Vol. 277, pp. 15507-15513.

Keaney J. F. 2011, «Immune modulation of atherosclerosis», Circulation, Vol. 124: e559-60.

Leuven S. L. 2008, «Systemic inflammation as a risk factor for atherothrombosis», Rheumatology, Vol. 47, pp. 3-7.

Ragino YI, Cherniavsky AM 2012 "The activity of the inflammatory process in different types of unstable atherosclerotic plaques," Bulletin of Experimental Biology and Medicine, T. 153, p. 150-153.

Dzidziguri LM 1989 "The importance of the immune system in the pathogenesis of atherosclerosis and coronary heart disease", Cand. Dis. Dr. med. Science, p. 46.

Chao Y.-S., Windler E. E. 1979, «Hepatic catabolism of rat and human lipoproteins in rats treated with 17-ethinyl estradiol», J. Biol. Chem., Vol. 254, pp. 11360-11366.

Singh V., Tiwari R. L., Dikshit M., Barthwal M. K. 2009, «Models to study atherosclerosis: a mechanistic insight», Curr. Vasc. Pharmacol., Vol. 7, pp. 75-109.

Fluiter K., Van Der Westhuijzen D. R., Van Berkel T. J. 1998, «In vivo regulation of scavenger receptor BI and the selective uptake of high density lipoprotein cholesteryl esters in rat liver parenchymal and Kupffer cells», J. Biol. Chem., V.273, pp. 8434–8438.




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