Violation of collagen metabolism in the development of renal scarring in patients with chronic pyelonephritis = Нарушение обмена коллагена при развитии нефросклероза у больных хроническим пиелонефритом

S. B. Pavlov, W. Zukow

Abstract


Pavlov S. B., Zukow W. Violation of collagen metabolism in the development of renal scarring in patients with chronic pyelonephritis = Нарушение обмена коллагена при развитии нефросклероза у больных хроническим пиелонефритом. Journal of Education, Health and Sport. 2016;6(6):263-278. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55365

http://ojs.ukw.edu.pl/index.php/johs/article/view/3575

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).

755 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author (s) 2016;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.05.2016. Revised 25.05.2016. Accepted: 10.06.2016.

 

UDC 616.61-002.3-07: 616,633,747

УДК 616.61-002.3-07:616.633.747

 

Violation of collagen metabolism in the development of renal scarring in patients with chronic pyelonephritis

Нарушение обмена коллагена при развитии нефросклероза у больных хроническим пиелонефритом

 

С. Б. Павлов, В. Жуков

S. B. Pavlov, W. Zukow

 

Харьковская медицинская академия последипломного образования, Харьков, Украина

Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

UMK, Toruń, Poland

UMK, Toruń, Poland

 

 

Summary

Introduction: The main mechanism for the development of chronic renal failure (CRF) is nephrosclerosis - the replacement of the kidney structures connective tissue. The more active the process of sclerosis, the faster irreversible consequences in the form of CKD. Therefore, the actual problem is the evaluation of the connective tissue (CT) reaction as the main mechanism of the pathological process of kidney sclerosis and above all the activity of collagen metabolism like nephrosclerosis marker.

Purpose: Identify collagen metabolism disturbances in patients with pyelonephritis, and development of a noninvasive method of research that characterizes the reaction of the connective tissue of a kidney.

Materials and methods: For the biochemical characteristics of the metabolism of the CT used for determining the amount of collagen hydroxyproline (OP). Oxiprolinuria daily was studied in groups of patients with chronic pyelonephritis (CP) at various stages of the pathological process. 1 group - patients with CP without manifestations of chronic renal failure, 2 group - patients with CP with the presence of pronounced manifestations of chronic renal failure

The results: There was a significant increase in daily excretion of OP in the urine of patients in both groups, most pronounced in patients with chronic renal failure. level selection OP urine - patients in group 1 42,4 ± 4,1 mg / day (p <0.01)in patients in group 2 66,0 ± 8,7 mg / day (p <0.01) at rate of 25,1 ± 0,72 mg / day. The average value of the level of OP patients in Group 1 higher than the average rate of 1.7 times, and the patients in group 2 - 2.6 times has been established that at the heart of sclerotic process is a violation of the dynamic equilibrium between production and the collapse of collagen, resulting in an increase in our daily oxsiprolinuria examinees. Interconnection activity sclerotic process in the kidneys and the content of OP in the urine of patients with CP can be used to develop methods adequate pathogenetic therapy on biochemical basis of monitoring.

 

Keywords: hydroxyproline, connective tissue, chronic renal failuremost.

 

 

Реферат

Введение: Основным механизмом развития хронической почечной недостаточности (ХПН) является нефросклероз – замещение структур почки соединительной тканью. Чем активнее процесс склерозирования, тем быстрее наступают необратимые последствия в виде развития ХПН. Поэтому актуальной проблемой является оценка реакции соединительной ткани (СТ) как основного механизма  патологического процесса склерозирования почки и прежде всего активности обмена коллагена как маркера нефросклероза.

Цель работы: выявление нарушений обмена коллагена у больных пиелонефритом, и разработка неивазивного метода исследования, характеризующего реакцию соединительной ткани почки.

Материалы и методы: Для биохимической характеристики метаболизма СТ использовали определение количества коллагена по оксипролину (ОП). Была изучена суточная оксипролинурия в группах больных хроническим пиелонефритом (ХП) на разных стадиях патологического процесса. 1 группа – больные ХП без проявлений ХПН, 2 группа – больные ХП с наличием выраженных проявлений ХПН.

Результаты работы: Наблюдалось достоверное повышение уровня суточной экскреции ОП с мочой у больных обеих групп, наиболее выраженное у больных с ХПН. Уровень выделения ОП с мочой составил: - у больных 1-й группы 42,4 ± 4,1 мг/сут (р < 0,01), у больных 2-й группы 66,0 ± 8,7 мг/сут (р < 0,01) при норме 25,1 ± 0,72 мг/сут. При этом среднее значение уровня ОП у больных 1-й группы превышало среднее значение нормы в 1,7 раза, а у больных 2-й группы — в 2,6 раза. Установлено, что в основе склеротического процесса лежит нарушение динамического равновесия между продукцией и распадом коллагена, следствием чего является увеличение суточной оксипролинурии у обследованных нами больных. Взаимосвязь активности склеротического процесса в почках и содержания ОП в моче больных ХП может быть использована для разработки методов адекватной патогенетической терапии на основе биохимического мониторинга.

 

Ключевые слова: оксипролин, соединительная ткань, хроническая почечная недостаточность.


Keywords


hydroxyproline, connective tissue, and chronic renal failure, оксипролин, соединительная ткань, хроническая почечная недостаточность.

Full Text:

PDF

References


References

Uchida S. Differential Diagnosis of Chronic Kidney Disease (CKD): By primary diseases // JMAJ. 2011. 54(1). P. 22–26.

Aliev R.M., Khyzikhanov F.V. Of medical and social prevention for patients with chronic pyelonephritis // Fundamental research.. 2015. № 1(6). pp. 1109-1111. (In Russ., abstr in Engl.).

Krutkina EE. The expert’s estimation of evolution of nephrosclerosis on patients with chronic glomerulonephritis // Problems of expertise in medicine. 2004. Vol. 4. № 16(4). pp. 30-32. (In Russ., abstr in Engl.).

Da Silva Lodge M. Extracellular matrix associated proteins and processing enzymes as urinary biomarkers of Chronic Kidney Disease. PhD thesis. University of Sheffield. 2015.

George J. Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis // Clin Biochem. 2006. 39(10). P. 984-991.

Ma F et al. Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II // PLoS ONE. 2012. 7(5): e35144. doi:10.1371/journal.pone.0035144.

O'Reilly S. et al. Interleukin-6: a new therapeutic target in systemic sclerosis? // Clinical & Translational Immunology. 2013. 2, e4; doi:10.1038/cti.2013.2.

Ai F, Chen M, Yu B et al. Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway // Int J Clin Exp Pathol. 2015. 8(10). P.12509-12516.

Jinnin M et al. Interleukin-13 Stimulates the Transcription of the Human α2(I) Collagen Gene in Human Dermal Fibroblasts // The Journal Of Biological Chemistry. 2004. Vol. 279(40). P. 41783–41791.

Berezhnaya NM, Chekhun VF. Physiological system of conjunctive tissue and oncogenesis. I. Role of cellular components of stroma in tumor development // Oncology. 2016. Vol. 18, № 1. pp. 4-14. (In Russ., abstr in Engl.).

Sraer J. Renal sclerosis: a public health problem // J Soc Biol. 2002. 196(4). P. 267-268. (In French).

Qian Y et al. From Fibrosis to Sclerosis Mechanisms of Glomerulosclerosis in Diabetic Nephropathy // Diabetes. 2008. 57(6). P. 1439-1445.

Koide T, Nagata K. Collagen biosynthesis // Top Curr Chem. 2005. 247. P. 85–114.

Shulutko BI, Ratner AM. Kidney disease. Leningrad: B. i., 1990. 80 p. (In Russ).

Sharaev PN, Botnikova EA, Ivanov VM et al. Determination of free and bound hydroxyproline in urine // Laboratornoe delo. 1990. № 12. pp. 64—66. (In Russ).

Pavlov S.B., Babenko N.M., Kumechko M.V. Metabolic role of connective tissue in the development of pathological processes of varying severity in the colon // Bulletin problems of biology and medicine. 2013. Issue 2, Vol. 2(101). pp. 133 – 136. (In Russ., abstr in Engl.).

Veligotskiy AN, Pavlov SB, Litvinova OB et al. Condition features of the connecting tissue of parenchymatous organs at obstructive diseases of the pancreaticoduodenal zone // Problems of modern medical science and education. 2008. № 4. pp. 18-19. (In Russ., abstr in Engl.).

Iredale JP, Thompson A, Henderson NC. Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation // Biochimica et Biophysica Acta. 2013. 1832(7). P. 876–883.

McKleroy W, Lee TH, Atabai K. Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis // Am J Physiol Lung Cell Mol Physiol. 2013. 304(11). P. 709–721.

Soufen H.N. et al. Collagen content, but not the ratios of collagen type III/I mRNAs, differs among hypertensive, alcoholic, and idiopathic dilated cardiomyopathy // Braz J Med Biol Res. 2008. Vol. 41(12). P. 1098-1104.

Литература

Uchida S. Differential Diagnosis of Chronic Kidney Disease (CKD): By primary diseases // JMAJ. 2011. 54(1). P. 22–26.

Алиев Р. М., Хузиханов Ф. В. Oрганизация медико-социальной профилактики среди больных хроническим пиелонефритом // Фундаментальные исследования. 2015. № 1(6). C 1109-1111.

Круткина Е. Э. Экспертная оценка развития нефросклероза у больных хроническим гломерулонефритом // Проблемы экспертизы в медицине. 2004. № 16(4). Т. 4. С. 30-32.

Da Silva Lodge M. Extracellular matrix associated proteins and processing enzymes as urinary biomarkers of Chronic Kidney Disease. PhD thesis. University of Sheffield. 2015.

George J. Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis // Clin Biochem. 2006. 39(10). P. 984-991.

Ma F et al. Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II // PLoS ONE. 2012. 7(5): e35144. doi:10.1371/journal.pone.0035144.

O'Reilly S. et al. Interleukin-6: a new therapeutic target in systemic sclerosis? // Clinical & Translational Immunology. 2013. 2, e4; doi:10.1038/cti.2013.2.

Ai F, Chen M, Yu B et al. Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway // Int J Clin Exp Pathol. 2015. 8(10). P.12509-12516.

Jinnin M et al. Interleukin-13 Stimulates the Transcription of the Human α2(I) Collagen Gene in Human Dermal Fibroblasts // The Journal Of Biological Chemistry. 2004. Vol. 279(40). P. 41783–41791.

Бережная Н.М., Чехун В.Ф. Физиологическая система соединительной ткани и онкогенез. I. Роль клеточных компонентов стромы в развитии опухоли // Онкология. 2016. Т. 18, № 1. С. 4-14.

Sraer J. Renal sclerosis: a public health problem // J Soc Biol. 2002. 196(4). P. 267-268 (In French).

Qian Y et al. From Fibrosis to Sclerosis Mechanisms of Glomerulosclerosis in Diabetic Nephropathy // Diabetes. 2008. 57(6). P. 1439-1445.

Koide T, Nagata K. Collagen biosynthesis // Top Curr Chem. 2005. 247. P. 85–114.

Шулутко Б.И., Ратнер А.М. Заболевания почек. Л.: Б. и., 1990. 80 с.

Шараев П.Н., Ботникова Е.А., Иванов В.М. и др. Определение свободного и связанного оксипролина в моче // Лаб. дело 1990. № 12. С. 64—66.

Павлов С.Б., Бабенко Н.М., Кумечко М.В. Роль обменных процессов соединительной ткани в развитии патологических процессов различной степени тяжести в ободочной кишке // Вісник проблем біології і медицини. 2013. Вип.2, Т. 2(101). С. 133 – 136.

Велигоцкий А.Н., Павлов С.Б., Литвинова О.Б. и др. Особенности состояния соединительной ткани паренхиматозных органов при обструктивных заболеваниях панкреатодуоденальной зоны // Проблеми сучасної медичної науки та освіти. 2008. № 4. С. 18-19.

Iredale JP, Thompson A, Henderson NC. Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation // Biochimica et Biophysica Acta. 2013. 1832(7). P. 876–883.

McKleroy W, Lee TH, Atabai K. Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis // Am J Physiol Lung Cell Mol Physiol. 2013. 304(11). P. 709–721.

Soufen H.N. et al. Collagen content, but not the ratios of collagen type III/I mRNAs, differs among hypertensive, alcoholic, and idiopathic dilated cardiomyopathy // Braz J Med Biol Res. 2008. Vol. 41(12). P. 1098-1104.




DOI: http://dx.doi.org/10.5281/zenodo.55365

Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 S. B. Pavlov, W.Zukow

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)