Разработка эффективной системы диагностики и профилактики дистресса плода путем изучения метаболических процессов у беременных с гипертензивными расстройствами и плацентарной недостаточностью = An effective system of fetal distress diagnosis and prevention development by metabolic processes in pregnant women with hypertensive disorders and placental insufficiency investigation

N. A. Gaystruk, O. O. Mazchenko

Abstract


Gaystruk N. A., Mazchenko O. O. Разработка эффективной системы диагностики и профилактики дистресса плода путем изучения метаболических процессов у беременных с гипертензивными расстройствами и плацентарной недостаточностью = An effective system of fetal distress diagnosis and prevention development by metabolic processes in pregnant women with hypertensive disorders and placental insufficiency investigation. Journal of Education, Health and Sport. 2016;6(6):155-176. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55172

http://ojs.ukw.edu.pl/index.php/johs/article/view/3567

 

The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).

755 Journal of Education, Health and Sport eISSN 2391-8306 7

© The Author (s) 2016;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 05.05.2016. Revised 25.05.2016. Accepted: 25.05.2016.

 

УДК 618.36;618.3-16,155.194.5.021

 

РАЗРАБОТКА ЭФФЕКТИВНОЙ СИСТЕМЫ ДИАГНОСТИКИ И ПРОФИЛАКТИКИ ДИСТРЕССА ПЛОДА ПУТЕМ ИЗУЧЕНИЯ МЕТАБОЛИЧЕСКИХ ПРОЦЕССОВ У БЕРЕМЕННЫХ С ГИПЕРТЕНЗИВНЫМИ РАССТРОЙСТВАМИ И ПЛАЦЕНТАРНОЙ НЕДОСТАТОЧНОСТЬЮ

 

Н. А. Гайструк, О. О. Мазченко

 

Винницкий национальный медицинский университет имени Н. И. Пирогова, Винница

 

Резюме

Представленная статья посвящена изучению современных исследований, которые касаются этиопатогенетических особенностей развития  дистресса плода у беременных с плацентарной недостаточностью. Проведенный анализ научных работ позволяет допустить, что разбалансирование регуляторных факторов многих систем организма у беременных с плацентарной недостаточностью может инициироваться дефицитом окислительных соединений азота, что приводит к усилению окислительной деструкции белков, что в свою очередь, может приводить к их деполимеризации, нарушений не только мембранно-транспортных функций клеток, но и к  гибели последних. При этом не исключена возможность индукции процессов апоптоза клеток плаценты, что может играть решающую роль в развитии плацентарной недостаточности, а значит, осложненном течении беременности. Оксид азота, влияя на процессы дилятации сосудистого русла, а значит на процессы оксигенации организма, при его дефиците может играть роль пускового механизма в срыве компенсаторных реакций в системе мать-плацента-плод. Дефицит оксида азота может возникать вследствии гипергомоцистеинэмии и гипоксии печени, уменьшения синтеза оксида азота, или повышения его использовання при возрастании активных форм кислорода, развития оксидативного стресса.

Изучено причины  возникновения дистресса плода у беременных  с гипертензивными расстройствами, разработаны методы диагностики и профилактики этой патологии беременности.

 

Ключевые слова: гипертензивные расстройства беременных, биохимическая альтерация, дистресс плода, гипергомоцистеинэмия, окислительная модификация белков, плацентарная недостаточность, актовегин.

 

AN EFFECTIVE SYSTEM OF FETAL DISTRESS DIAGNOSIS AND PREVENTION DEVELOPMENT BY METABOLIC PROCESSES IN PREGNANT WOMEN WITH HYPERTENSIVE DISORDERS AND PLACENTAL INSUFFICIENCY INVESTIGATION

 

N. A. Gaystruk, O. O. Mazchenko

 

N. I. Pirogov Vinnitsa National Medical University, Vinnitsa

 

Summary

This representative article is devoted to learning modern investigations, which belong to ethiopathogenetic peculiarities of fetal distress development in the pregnant women placental insufficiency. The analysis of scientific works allows to assume that regulatory factors disorder of many systems of the organism in pregnant women with hypertension can be initiated by nitrogen oxide compound deficiency, which leads to protein oxidized destruction increasing. This protein destruction leads to its depolymerization, disorder not only of membrane-transportal function of the cells, but to death of the last ones. In this case the indication of the apoptosis of the placenta’s cells is possible, which can play the major role placentary disorder development, and as the result to complicated course of the pregnancy. Nitrogen oxide has ability to influence on dilatation of vessels and oxygenation processes of the organism. Nitrogen oxide deficiency can play the role of the starting of compensatory mechanism disorder in the mother-placenta-fetus system. Nitrogen oxide deficiency may be as the result of the hyperhomocysteinenia, liver hypoxia, decreasing of nitrogen oxide synthesis or increasing its using during elevation of oxygen active forms, oxidative stress.

The authors research the courses of the development of the fetal distress in pregnant women with hypertensive disorders, work the methods of the diagnostic and prevention of this pathology.

 

Key words: pregnant women with hypertensive disorders, biochemical alterations, fetal distress, hyperhomocysteinemia, oxygen modification of proteins, placentary failure, actovegin.


Keywords


pregnant women with hypertensive disorders, biochemical alterations, fetal distress, hyperhomocysteinemia, oxygen modification of proteins, placentary failure, actovegin.

Full Text:

PDF (Russian)

References


Список литературы

Гайструк Н.А. Роль женской консультации в профилактике антенатальной гибели плода при гипертензивном синдроме / Н.А. Гайструк, А.Н. Гайструк, О.В. Булавенко // Збірник наукових праць асоціації акушерів-гінекологів України. - Київ, 2003. - С. 51-56.

Роль психоемоційного зриву у виникненні плацентарної недостатності у у вагітних з гіпертензивними розладами / Гайструк А.Н., Гайструк Н.А., Мазченко О.О., Мельник А.В. // Biomedical Biosocial Antropology. – 2008. - № 11. - С. 150-153.

Доклад рабочей группы Всероссийского научного общества кардиологов по высокому артериальному давлению при беременности. - М.: 2007. - 48 с.

Знаменская Т.К. Влияние гипоксии на развитие плода и новорожденного / Т.К. Знаменская, Л.И. Шевченко // Перинатология и педиатрия. - 2006. - № 2(26). - С. 105-108.

Меллина И.М. Профилактика преэклампсии- основа предотвращения материнской и перинатальной смертности у женщин с гипертонической болезнью / И.М. Меллина // Здоровье женщины. - 2009. - № 5. - С.35-36.

Оганов Р.Г. Лечебно-диагностическая тактика ведения беременных а артериальной гипертензией в России. / Р.Г. Оганов // Акушерство и гинекология. - 2010. - № 6. - С. 30-36.

Оценка влияния артериальной гипертензии у беременных на гемодинамику в системе мать-плацента-плод и развитие плода / Татарченко И.Б., Молокова Е.О., Морозова О.М., Фатеева Л.А. // Врач. - 2007. - №3. - С. 98-100.

Савельева Г.М. Эклампсия в современном акушерстве / Г.М. Савельева // Акушерство и гинекология. - 2010. - № 6. - С. 4-9.

Савельева Г.М. Материнская смертность и пути ее снижения / Г.М. Савельева, М.А. Курцер, Р.И. Шалина // Акушерство и гинекология. - 2009. - № 3. - С.11-15.

Яворський П.В. Рання діагностика, причини розвитку та профілактика прееклампсії у вагітних / П.В. Яворський. – Автореф. дис. к.мед.н. - Вінницький НМУ ім. М.І. Пирогова. – Вінниця, 2008. - 20 с.

ACOG compendium of selected publications: Antepartum Fetal surveilence. - 2009. - 634 p.

Practical aspects of Doppler sonography in obstetrics / Aranyosi J., Zatik J., Jakab A. Jr. et al. // Orv. Hetil. - 2003. - Vol. 144, N 34. - P. 1683-1686.

Barry C. Hypertension in pregnancy: the management of hypertensive disorders during pregnancy / C. Barry // National Collaborating Centre for Women's and Children Health. - Barry C., Fielding R., Green P. et al. Eds. – London : Royal of College Obstetrics and Gynecologic, 2010. - 296 p.

Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids / Kapoor A., Dunn E., Kostari A. et al. // J. Physiol. - 2006. - Vol. 572, N 1. - P. 31-44.

Gagnon R. The use of fetal Doppler in obstetrics / R. Gagnon, M. van den Hof // J. Obstet. Gynaec. Can. - 2003. - Vol. 25, N 7. - P. 601-614.

Gressens P. Mechanisms of action of tobacco smoke on the developing brain / P. Gressens, V. Laudenbach, S. Marret // J. Gynec. Obstet. Biol. Reprod. - 2003. - Vol. 32, Suppl. 1. - S. 30-32.

Grivell R.M. Regimens of fetal surveillance for impared fetal growth / R.M. Grivell, L. Wong, V. Bhatia // The Cohrane Library. - 2009. - N 1. - Р. 20.

Harrington K. Doppler Ultrasound of the uterine arteries; the importance of bilateral not ching in the prediction of the preeclampsia, placental abruption or deliver of a small for gestational age baby / K. Harrington, D. Cooper, C. Lees // Ultrasound Obstetrics Gynecologic. – 2006. – Vol. 7, N 3. – P. 182-188.

The relationship between pregnancy induced hypertension and congenital thrombophilia / Demir S.C., Evruke C., Ozgunen T. et al. // Saudi Med. J. – 2006. – Vol. 27, N 8. – P. 161-166.

Magee L.A. Oral beta-blokers for mild to moderate hypertension during pregnancy. 2007 Guidelines for the management of arterial hypertension / L.A. Magee, L. Duley //J. Hypertension. – 2007. – Vol. 25. – P. 990-998.

Excess placental soluble fms-like tyrosine kinase 1 (Sflt 1) may contribute to endothelial dysfunction, hypertension and proteinuria in preeclampsia / Maynard S.E., Min J.Y., Merchan J., Lim K.H. // J. Clin. Invest. – 2003. – Vol. 111. – P. 649-658.

Parra M. Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction / M. Parra, R. Rodrigo // Am. J. Obstetrics Gyn. – 2005. – Vol. 193. – P. 1486-1491.

Podimow T. Update on the use of Antihypertensive Drugs in pregnancy / T. Podimow, P. August // Hypertension. - 2008. – Vol. 51. - P. 960-969.

2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) / Mancia G., De Backer G., Dominiczak A. et al. // J. Hypertens. – 2007. – Vol. 25, N 6. – P. 1105-1187.

Tsatsaris V. Circulating angуogenic factors and preeclampsia / V. Tsatsaris, F. Goffin, J.M. Foidart // N. Engl. J. Med. – 2004. – Vol. 350. – P. 2003-2004.

References

Gaystruk N.A. The role of the women's clinic in the prevention of fetal death with hypertensive syndrome / N.A. Gaystruk, A.N. Gaystruk, O.V.Bulavenko // Proc. of the Ukrainian Assoc. of Obstetricians and Gynecologists. - Kyiv, 2003. - P. 51-56 (In Russian).

The role of emotional breakdown in the occurrence of placental insufficiency in pregnant women with hypertensive disorders / Gaystruk А.N., Gaystruk N.А., Mazchenko О.О., Melnik А.V. // Biomedical Biosocial Antropology. – 2008. - N 11. - P. 150-153 (In Ukrainian).

Report of the Working Group of All-Russian Scientific Society of Cardiology for high blood pressure during pregnancy. - М.: 2007. - 48 p. (In Russian).

Znamenskaya Т.К. The influence of hypoxia on the development of the fetus and newborn / Т.К. Znamenskaya, L.I. Shevchenko // Perinatology & Pediatry. - 2006. - N 2(26). - P. 105-108 (In Russian).

Mellina I. M. Preeklampsy prevention os the basis for prevention of maternal and perinatal mortality in women with hypertension / I.М. Mellina // Woman’ Health. - 2009. - N 5. - P.35-36 (In Russian).

Оganov R.G. Therapeutic and diagnostic tactics for pregnant women with hypertension in Russia / R.G. Оganov // Obstetrics & Gynecology. - 2010. - N 6. - P. 30-36 (In Russian).

Assessing the impact of hypertension in pregnant women on hemodynamics in the mother-placenta-fetus and fetal development / Tatarchenko I.B., Molokova Ye.O., Моrozova О.М., Fateyeva L.А. // Doctor. - 2007. - N3. - P. 98-100 (In Russian).

Savelyeva G.M. Eclampsia in modern obstetrics / G.М. Savelyeva // Obstetrics & Gynecology. - 2010. - N 6. - P. 4-9 (In Russian).

Savelyeva G.M. Maternal mortality and ways to reduce it / G.М. Savelyeva, М.А. Кurcer, R.I. Shalina // Obstetrics & Gynecology. - 2009. - N 3. - P.11-15 (In Russian).

Yavorskiy P.V. Early diagnosis, causes and prevention of preeclampsia in pregnant women / P.V. Yavorskiy. – PhD (Medicine) Thesis. – M.I.Pirogov National University. – Vinnitsya, 2008. - 20 p. (In Ukrainian).

ACOG compendium of selected publications: Antepartum Fetal surveilence. - 2009. - 634 p.

Practical aspects of Doppler sonography in obstetrics / Aranyosi J., Zatik J., Jakab A. Jr. et al. // Orv. Hetil. - 2003. - Vol. 144, N 34. - P. 1683-1686.

Barry C. Hypertension in pregnancy: the management of hypertensive disorders during pregnancy / C. Barry // National Collaborating Centre for Women's and Children Health. - Barry C., Fielding R., Green P. et al. Eds. – London : Royal of College Obstetrics and Gynecologic, 2010. - 296 p.

Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids / Kapoor A., Dunn E., Kostari A. et al. // J. Physiol. - 2006. - Vol. 572, N 1. - P. 31-44.

Gagnon R. The use of fetal Doppler in obstetrics / R. Gagnon, M. van den Hof // J. Obstet. Gynaec. Can. - 2003. - Vol. 25, N 7. - P. 601-614.

Gressens P. Mechanisms of action of tobacco smoke on the developing brain / P. Gressens, V. Laudenbach, S. Marret // J. Gynec. Obstet. Biol. Reprod. - 2003. - Vol. 32, Suppl. 1. - S. 30-32.

Grivell R.M. Regimens of fetal surveillance for impared fetal growth / R.M. Grivell, L. Wong, V. Bhatia // The Cohrane Library. - 2009. - N 1. - Р. 20.

Harrington K. Doppler Ultrasound of the uterine arteries; the importance of bilateral not ching in the prediction of the preeclampsia, placental abruption or deliver of a small for gestational age baby / K. Harrington, D. Cooper, C. Lees // Ultrasound Obstetrics Gynecologic. – 2006. – Vol. 7, N 3. – P. 182-188.

The relationship between pregnancy induced hypertension and congenital thrombophilia / Demir S.C., Evruke C., Ozgunen T. et al. // Saudi Med. J. – 2006. – Vol. 27, N 8. – P. 161-166.

Magee L.A. Oral beta-blokers for mild to moderate hypertension during pregnancy. 2007 Guidelines for the management of arterial hypertension / L.A. Magee, L. Duley //J. Hypertension. – 2007. – Vol. 25. – P. 990-998.

Excess placental soluble fms-like tyrosine kinase 1 (Sflt 1) may contribute to endothelial dysfunction, hypertension and proteinuria in preeclampsia / Maynard S.E., Min J.Y., Merchan J., Lim K.H. // J. Clin. Invest. – 2003. – Vol. 111. – P. 649-658.

Parra M. Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction / M. Parra, R. Rodrigo // Am. J. Obstetrics Gyn. – 2005. – Vol. 193. – P. 1486-1491.

Podimow T. Update on the use of Antihypertensive Drugs in pregnancy / T. Podimow, P. August // Hypertension. - 2008. – Vol. 51. - P. 960-969.

2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) / Mancia G., De Backer G., Dominiczak A. et al. // J. Hypertens. – 2007. – Vol. 25, N 6. – P. 1105-1187.

Tsatsaris V. Circulating angуogenic factors and preeclampsia / V. Tsatsaris, F. Goffin, J.M. Foidart // N. Engl. J. Med. – 2004. – Vol. 350. – P. 2003-2004.




DOI: http://dx.doi.org/10.5281/zenodo.55172

Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 N. A. Gaystruk, O. O. Mazchenko

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)