CONSISTENT HUMORAL IMMUNITY CONDITION IN PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS ON THE BACKGROUND OF PARASITIC INVASION

Natal'ya Saval'eva, Stanislav Shnayder

Abstract


The article reveals the results of the immunity humoral chain investigation in patients with the chronic generalized periodontitis (CGP), severity level I-II, in combination with parasitosis.

The purpose of the investigation is to verify the role and place of humoral immunity in CGP pathology in patients with parasitosis.

Materials and methods. Immunologic investigations were conducted among 540 patients with the chronic generalized periodontitis, severity level I-II, on the background of parasitic invasions (gisrdiasis, enterobiasis, toxocarosis) – (principle groups). The experimental group consisted of 90 CGP patients, severity level I-II, without parasitic invasions. The control group consisted of 30 people without the parodontium pathology and the chronic pathology of other organs and systems, who were considered practically healthy during the investigation.

Humoral immunity condition in CGP patients was estimated by the content level of antibodies against etiological inflectional agents in the blood serum and the common antigenic determinant (CAD) of microbes, antimicrobial IgG- antibodies affinity, by the content of IgА. IgМ, IgЕ, CIC, complement activity.

Results and conclusions. It is noted that increasing of IgE, CIC and complement levels in blood are the peculiarity of immune structures in the organism of CGP patients with parasitosis, compared with CGP patients without parasitosis. While investigating the qualitative characteristics of the produced antimicrobial antibodies, it was found that in CGP patients, I-II severity level, with parasitosis the antibodies affinity was significantly lower than in CGP patients without parasitosis. Weak antibody immune response to the microbial factor and low produced antimicrobial antibodies affinity, apparently, explain the impossibility for the patient to neutralize and eliminate the bacteria, populating the periodontal pockets, as well as to maintain normal mouth cavity biocenosis. The obtained data also explain, why in CGP patients with parasitosis the degree of microbial colonization of periodontal pockets and species composition of microbial associations is higher than in patients without parasitosis.


Keywords


chronic generalized periodontitis; sectorial IgA; IgА; IgМ; IgЕ; consistent immunity; antibodies; complement; parasitosis

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References


Список литературы:

Современные критерии оценки стоматологического статуса при проведении эпидемиологического обследования населения [Текст] / Э. М. Кузьмина, С. А. Васина, И. Н. Кузьмина [и др.] // Российский стоматологический журнал. – 2009. – № 4. – С. 27.

Борисенко А. В. Пародонтит грозит не только потерей зубов, но и поражением внутренних органов [Электронный ресурс] / А. В. Борисенко. – Режим доступа: http://www.zid.com.ua/rus_creativework/parodontyt-hrozyt-ne-tolko-poterej-zubov-no-y-porazhenyem-vnutrennyh-orhanov.

Заболевания пародонты [Текст] / под ред. Л. О. Ореховой. – М. : Поли Медиа Пресс, 2004. – 432 с.

Кузьмина Э. М. Стоматологическая заболеваемость в России [Текст] / Э. М. Кузьмина. – М. : Медицина, 1999. – 156 с.

Данилевский Н. Ф. Заболевания пародонта [Текст] / Н. Ф. Данилевский, А. В. Борисенко. – Киев : Здоров’я, 2000. – 448 с.

Ткаченко А. Г. Профилактика лекарственной нагрузки на пародонт при лечении генерализованного пародонтита у лиц молодого возраста [Текст] / А. Г. Ткаченко // Современная стоматология. – 2005.– №2.– С. 77–79.

Чиркин В. В. Спектрофотометрический метод определения концентрации сывороточных иммуноглобулинов трех классов / В. В. Чиркин, Ю. Ю. Веников, Г. И. Кожевников // Иммунология. – 1990. – №3. – С. 75-77.

Фролов В. М. Аутоиммунная и иммунокомплексная патология у больных инсулинзависимым сахарным диабетом [Текст] / В. М. Фролов, Л. Л. Пинский, Н. А. Пересадин // Проблемы эндокринологии. – 1991. – № 5. – С. 22–24.

Особенности клинико- иммунологического действия ликопида при некоторых хронических заболеваниях ЛОР-органов / С. В. Филатова, А. В. Симонова, М. Е. Артемьев [и др.] // Иммунология. – 2001. – №2. – С.37-42.

Luxton R. W. Affinity distributions of antigen-specific IgG in patients with multiple sclerosis and in patients with viral encefalitis / R. W. Luxton, E. J. Tompson // J. Immunol. Meth. – 1990. – № 131. – C. 277–282.

Тельнюк Я. И. Особенности иммунной системы больных хроническим рецидивирующим фурункулезом и влияние на нее иммунотропной терапии [Текст] / Я. И. Тельнюк, Н. Х. Сетдикова, М. М. Карсонова // Иммунология. – 2003. – № 1. – С. 20–23.

Гмурман В. Е. Теория вероятностей и математическая статистика [Текст] / В. Е. Гмурман. – М. : Высшее образование, 2007. – 479 с.

Гланц С. Медико-биологическая статистика [Текст] / С. Гланц. – М. : Изд-во Практика, 1999. – 459 с.

Лакин Г. Ф. Биометрия [Текст] / Г. Ф. Лакин. – М.: Высшая школа, 1990. – 352 с.

References

Kuz'mina I.N., Kuz'mina E.M, Smirnova T.A., Vasina S.A., Petrina S.E. The modern criteria for evaluation of dental status in epidemiological population surveys. Rossiyskiy stomatologicheskiy zhurnal. 2009; 4: 27.

Borisenko A.V. Periodontitis is threatened not only the loss of teeth, but also visceral involvement. Mode of access: http://www.zid.com.ua/rus_creativework/parodontyt-hrozyt-ne-tolko-poterej-zubov-no-y-porazhenyem-vnutrennyh-orhanov.

Orekhova L.O. Zabolevaniya parodonty [Periodontal disease]. Moskva, Poli Media Press, 2004: 432.

Kuz'mina E.M. Stomatologicheskaya zabolevaemost' v Rossii [Dental disease in Russia]. Moskva, Meditsina, 1999: 156.

Danilevskiy N.F., Borisenko A.V. Zabolevaniya parodonta [Periodontal disease]. Kiev, Zdorov’ya, 2000: 448.

Tkachenko A.G. Prevention of drug load on the treatment of periodontal generalized periodontitis in young adults. Sovremennaya stomatologiya, 2005;2:77–79.

Chirkin V.V., Venikov Yu.Yu., Kozhevnikov G.I. Spectrophotometric method for determining the concentration of serum immunoglobulins of three classes. Immunologiya, 1990;3:75-77.

Frolov V.M., Pinskiy L.L., Peresadin N.A. Autoimmune and immunocomplex pathology in patients with insulin-dependent diabetes. Problemy endokrinologii, 1991;5:22–24.

Filatova S.V., Simonova A.V., Artem'ev M.E. Features of clinical and immunological activities licopid in some chronic diseases of upper respiratory tract. Immunologiya. 2001;2:37-42.

Luxton R.W., Tompson E.J. Affinity distributions of antigen-specific IgG in patients with multiple sclerosis and in patients with viral encephalitis. J. Immunol. Meth. 1990;131:277-282.

Tel'nyuk Ya.I., Setdikova N.Kh., Karsonova M.M. Features of the immune system of patients with chronic recurrent boils and the influence of immunotropic therapy. Immunologiya. 2003;1:20–23.

Gmurman V. E. Teoriya veroyatnostey i matematicheskaya statistika [Theory of Probability and Mathematical Statistics]. Moskva, Vysshee obrazovanie, 2007:479.

Glants S. Mediko-biologicheskaya statistika [Biomedical Statistics]. Moskva, Izd-vo Praktika, 1999: 459.

Lakin G. F. Biometriya [Biometrics]. Moskva, Vysshaya shkola, 1990:352.


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