Антиоксидантное действие оральных аппликаций кверцетинсодержащих гелей у крыс, получавших антихеликобактерную терапию = Antioxidant effect of gels containing quercetin which were applied orally to rats treated with antihelicobacter pyloli therapy

T. V. Tomilina

Abstract


Tomilina T.V. Антиоксидантное действие оральных аппликаций кверцетинсодержащих гелей у крыс, получавших антихеликобактерную терапию = Antioxidant effect of gels containing quercetin which were applied orally to rats treated with antihelicobacter pyloli therapy. Journal of Education, Health and Sport. 2015;5(2):179-186. ISSN 2391-8306. DOI: 10.5281/zenodo.15993

http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%282%29%3A179-186

https://pbn.nauka.gov.pl/works/545172

http://dx.doi.org/10.5281/zenodo.15993

Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive

 

Deklaracja.

Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.

Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.

The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).

© The Author (s) 2015;

This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland

Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,

provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License

(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.

This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 20.10.2014. Revised 18.01.2015. Accepted: 25.02.2015.

 

УДК 616.33+342.092

 

Антиоксидантное действие оральных аппликаций кверцетинсодержащих гелей у крыс, получавших антихеликобактерную терапию

 

Antioxidant effect of gels containing quercetin which were applied orally to rats treated with antihelicobacter pyloli therapy

 

Т.В. Томилина

T.V. Tomilina

 

Харьковский национальный медицинский университет (Украина)

e-mail: flavan@mail.ru

Kharkov National Medical University (Ukraine)

 

Article

Aim: To determine the development of lipid peroxidation (LPO) in the tissues of rats treated with antihelicobacter pyloli therapy (AHBT) and after oral applications of gels containing quercetin.

Materials and Methods: Rats received the following doses of AHBT daily during 8 days: omeprazole - 1.3 mg / kg, amoxil - 50 mg / kg of clarithromycin and - 7.5 mg / kg. Gels containing quercetin (quertulin = quercetin + inulin + calcium citrate and quertulidon = quercetin + imudon) were applied to the oral mucosa (OM) at the daily dose 0.5 ml for 11 days. Euthanasia of rats was performed on the 12th day. Malondialdehyde (MDA) and catalase activity were analyzed in the tissues of cheeks, gums, stomach, liver and blood serum; and antioxidant-prooxidant index ProAntidex was calculated as ratio of catalase acivity to MDA content.

Results: It was found that in affected tissues there were high levels of MDA and low ProAntidex. Gels containing quertecin reduce the level of MDA and increase ProAntidex in the tissues, and gums were most sensitive to the gels’ action.

Conclusion: Increased LPO is an important pathogenetic link in the development of complications in AHBT.

Key words: antihelicobacter pyloli therapy, lipid peroxidation, quercetin.

 

Резюме

Антихеликобактерная терапия (омепразол + амоксил + кларитромицин) вызывает в тканях крыс повышение уровня МДА и снижение антиоксидантно-прооксидантного индекса АПИ. Оральные аппликации кверцетинсодержащих гелей (квертулин и квертулидон) снижают содержание МДА и повышают АПИ.

Ключевые слова: антихеликобактерная терапия, перекисное окисление липидов, кверцетин.


Keywords


антихеликобактерная терапия, перекисное окисление липидов, кверцетин, antihelicobacter pyloli therapy, lipid peroxidation, quercetin.

Full Text:

PDF (Russian)

References


Kharchenko N. V., Barchuk M. A. The actual approach in anti-helicobacter therapy in patients with ulcerous disease. Zhurnal praktykujuchogo likarja. 2001; 3: 24-27.

Tsimmerman Ya. S. Helicobacter pylori-infection: outergastric effects and diseases (the critical analysis). Klinicheskaya meditsina. 2006; 4: 63-67.

Yakovljeva L. V., Saharova T. S., Bunjatjan N. D. [et al.]. Lipid peroxidation and antioxi-dants at stomach ulcers. Klinichna farmacija. 1999; 3(1): 27-29.

Khajuria A. Lipid peroxidation. Everyman’s Sci. 1997; 32(3): 109-113.

Stalnaya I. D., Garishvili T. G. Metod opredeleniya malonovogo dialdegida s pomoshchyu tiobarbiturovoy kisloty [The method of revelation of malonic dialdehyde with thiobarbituric acid]. Moskva, Meditsina, 1977: 66-68.

Girin S. V. The modification of the method of the determination of catalase activity in biological substrates. Laboratornaya diagnostika. 1999; 4: 45-46.

Levitsky A. P., Denga O. V., Makarenko O. A. [i dr.]. Biokhimicheskie markery vospaleniya tkaney rotovoy polosti: metodicheskie rekomendatsii [Biochemical markers of inflammation of oral cavity tissue: method guidelines]. Оdеssа, KP OGT, 2010: 16.

Levitsky A. P., Makarenko O. A., Selivanskaya I. A. [et al.]. Kvertulin. Vitamin P, prebiotik, gepatoprotektor [“Querthulin”, Vitamin P, prebiotic, hepatoprotector].Оdеssа, KP OGT, 2012:20.

Lapach S.N., Chubenko A.V., Babich P.N. Statisticheskiye metody v medico-biologicheskikh issledovaniyakh s ispolzovaniem Excel [Statistical methods in medical and biological research by using Excel]. Kiyev, Morion, 2000: 320.


Refbacks

  • There are currently no refbacks.




Copyright (c)



Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

Journal Language(s): English 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Instytut Kultury Fizycznej Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Institute of Physical Education Kazimierz Wielki University in Bydgoszcz, Poland 85-091 Bydgoszcz ul. Sportowa 2  www.ukw.edu.pl Copyright by Instytut Kultury Fizycznej UKW w Bydgoszczy http://ojs.ukw.edu.pl/index.php/johs  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

SIC Science citation index (calculated on the basis of TCI and Page Rank) 0

Russian Impact factor 0.16

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

The InfoBase Index IBI Factor for the year 2015 is 3.56 in InfoBase Index.com.

Website: www.infobaseindex.com

Universal Impact Factor 1.78 for year 2012. (http://www.uifactor.org/AppliedJournals.aspx)

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)